Some Variables Affecting the Formulation of Ketoprofen Sustained Release Oral Tablet using Polyelectrolyte Complex as a Matrix Former

Sabar, Methaq Hamad; Samein, Laith H.; Sahib, Hayder B

doi:10.3923/jpahs.2011.1.15

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…[4][5][6][7][8] Among these, drug-release studies demonstrated that high drug loadings can be achieved with aerogels and the drugs adsorbed on hydrophilic silica aerogels dissolve faster than the crystalline drugs. 18 Although dosage concentration ranges from 25 to 200 mg per tablet in clinics, in these applications, amount of the drug applied ranges from 4 to 285 mg. [19][20][21][22][23][24][25] Due to its short shelf life, this drug requires frequent dosage when administered orally, which results in increased level of adverse effects such as gastrointestinal side effects (irritation, bleeding) and renal side effects. Also, due to their bio-compatibility, their applications in pulmonary drug delivery and feasibility to apply as oral drug delivery devices have been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 For these diseases, there is a great effort to control sustained release of ketoprofen from various carriers such as poly(vinyl alcohol) nanofibers, 17 dendrimers, 16 bioadhesive gels, 15 and microparticles. 18 Although dosage concentration ranges from 25 to 200 mg per tablet in clinics, in these applications, amount of the drug applied ranges from 4 to 285 mg. [19][20][21][22][23][24][25] Due to its short shelf life, this drug requires frequent dosage when administered orally, which results in increased level of adverse effects such as gastrointestinal side effects (irritation, bleeding) and renal side effects. When it is applied transdermally, it faces the natural barrier, skin, which limits the penetration of the drug.…”

Section: Introductionmentioning

confidence: 99%

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Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system

Giray

Bal

Kartal

et al. 2012

J Biomedical Materials Res

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A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system

Giray

Bal

Kartal

et al. 2012

J Biomedical Materials Res

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“…The value of ( n ) allows the release to be characterized as either Fickian diffusion n ⩽ 0.5, anomalous diffusion (non-Fickian) (0.5 < n < 1) or zero-order release ( n = 1) (Costa and Sousa Lobo, 2001). The n values for F2 and F4 were 0.53 and 0.56 respectively, that indicated anomalous diffusion (non-Fickian) which refers to a combination of both diffusion and erosion controlled-drug release (Sabar et al, 2011). Whereas, the value of ( n ) in case of F1 ( n = 0.39) revealed a Fickian diffusion mechanism of LVF from these mini-tablets.…”

Section: Resultsmentioning

confidence: 99%

Design and evaluation of gastroretentive levofloxacin floating mini-tablets-in-capsule system for eradication of Helicobacter pylori

El‐Zahaby

Kassem

El-Kamel

2014

Saudi Pharmaceutical Journal

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Gastroretentive levofloxacin (LVF) floating mini-tablets for the eradication of Helicobacter pylori (H. pylori) were prepared using the matrix forming polymer hydroxypropyl methylcellulose (HPMC K100M), alone or with Carbopol 940P in different ratios by wet granulation technique. Buoyancy of mini-tablets was achieved by an addition of an effervescent mixture consisting of sodium bicarbonate and anhydrous citric acid to some formulations. The prepared mini-tablets were evaluated for weight variation, thickness, friability, hardness, drug content, in vitro buoyancy, water uptake and in vitro release. The optimized formula was subjected to further studies: FT-IR, DSC analysis and in vivo examination in healthy volunteers. The prepared mini-tablets exhibited satisfactory physicochemical characteristics. Incorporation of gas-generating agent improved the floating parameters. HPMC K100M mini-tablet formulation (F1) offered the best controlled drug release (>8 h) along with floating lag time <1 s and total floating time >24 h. The obtained DSC thermograms and FT-IR charts indicated that there is no positive evidence for the interaction between LVF and ingredients of the optimized formula. The in vivo test confirmed the success of the optimized formula F1 in being retained in the stomach of the volunteers for more than 4 h. LVF floating mini-tablets based on HPMC K100M is a promising formulation for eradication of H. pylori.

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“…Ketoprofen may be a candidate for formulation in controlled release dosage forms due to its short half-life and its poor solubility in water, which affects its bioavailability 15&16 . Therefore, in order to maintain therapeutic plasma levels, modified release dosage forms may be beneficial for allowing only one daily dose of the drug with consequent improvement of patient compliance [17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Formulation and in-Vivo Study of Ketoprofen Tablets Prepared Using Chitosan Interpolymer Complexes

El-Gawad

Ramadan

Soliman

et al. 2012

Bulletin of Pharmaceutical Sciences. Assiut

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The application of interpolymer complexes (IPCs) for oral controlled drug delivery systems was tested between chitosan and various anionic polymers viz sodium alginate, sodium carboxymethylcellulose and pectin. The prepared IPCs were investigated using Fourier transform infra-red spectroscopy and differential scanning calorimetry. Ketoprofen tablets were prepared using the polymers alone, physical mixtures of chitosan with sodium alginate, sodium carboxymethylcellulose or pectin in different ratios; 1:3, 1:1 and 3:1, and the corresponding IPCs. In-vitro release studies were carried out in two dissolution media; 0.1 N HCl of pH 1.2 and phosphate buffer of pH 7.4. It was found that, chitosan-sod. carboxymethylcellulose IPC tablets showed more controlled drug release compared to that containing chitosan-sodium alginate and chitosanpectin IPCs. The dissolution rate from tablets prepared using physical mixtures of polymers were found to be dependant on the interaction between chitosan and each of the anionic polymers in the physical mixtures, their ratios and pH of the dissolution medium. Tablets prepared using chitosan-sod. carboxymethylcellulose physical mixture 1:1 and chitosan-sod. carboxymethylcellulose IPC were selected for the in-vivo study using albino rabbits. The results showed a lower peak plasma concentration and marked controlled release effect of drug in tablets containing the physical mixture compared to that of the IPC and the control tablets.

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Some Variables Affecting the Formulation of Ketoprofen Sustained Release Oral Tablet using Polyelectrolyte Complex as a Matrix Former

Cited by 7 publications

References 35 publications

Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system

Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system

Design and evaluation of gastroretentive levofloxacin floating mini-tablets-in-capsule system for eradication of Helicobacter pylori

Formulation and in-Vivo Study of Ketoprofen Tablets Prepared Using Chitosan Interpolymer Complexes

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