Some thoughts on place cells and the hippocampus

Many of the ascending pathways to the thalamus have branches involved in movement control. In addition, the recently defined, rich innervation of 'higher' thalamic nuclei (such as the pulvinar) from pyramidal cells in layer five of the neocortex also comes from branches of long descending axons that supply motor structures. For many higher thalamic nuclei the clue to understanding the messages that are relayed to the cortex will depend on knowing the nature of these layer five motor outputs and on defining how messages from groups of functionally distinct output types are combined as inputs to higher cortical areas. Current evidence indicates that many and possibly all thalamic relays to the neocortex are about instructions that cortical and subcortical neurons are contributing to movement control. The perceptual functions of the cortex can thus be seen to represent abstractions from ongoing motor instructions.

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“…Lond. B ( 2002) pal and adjacent cortex (Taube 1999). However, the anterior thalamic cells discharge ca.…”

Section: (B) First-order Thalamic Relays (I) the Retinothalamic Pathwaymentioning

confidence: 99%

The thalamus as a monitor of motor outputs

Güillery

Sherman

2002

Phil. Trans. R. Soc. Lond. B

109

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“…More so, hippocampus hyperactivity has been suggested to be a putative cause of anxiety disorders [44]. In the context of vestibular impairment and memory, a large amount of neurophysiological and behavioral evidence collected throughout the years suggests that the hippocampus makes an extensive use of information from the vestibular system to build cognitive spatial maps, and to successfully develop normal abilities of spatial memory [40,45]. Damages to the vestibular system, directly at the inner ear level, cause molecular changes in the hippocampus.…”

Section: The Limbic System: a Multimodal Integrator?mentioning

confidence: 99%

Tinnitus and Anxiety: More than Meets the Ear

Guitton

2006

CPSR

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Tinnitus is an abnormal perception of sound that cannot be attributed to an external source. In most cases, tinnitus is caused by insults to the peripheral auditory system. Tinnitus also displays strong links with negative emotional states such as anxiety. However, the relations of tinnitus with anxiety are still debated. Of particular interest is the question whether the occurrence of tinnitus is, at least partially, consecutive to high level of anxiety, or whether tinnitus is anxiogenic. This review aims to summarize recent knowledge on the fascinating topic of interactions of tinnitus with anxiety. Furthermore, using tinnitus as an example, this review tries to nurture the more inclusive debate on the relation between perception, emotion and memory in human pathologies.

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Gonadal Steroids, Learning, and Memory

Dohanich

2002

Hormones, Brain and Behavior

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Some thoughts on place cells and the hippocampus

Abstract: This commentary addresses five issues related to the functional role of place cells and the hippocampus.

Cited by 7 publications

References 42 publications

The thalamus as a monitor of motor outputs

The thalamus as a monitor of motor outputs

Tinnitus and Anxiety: More than Meets the Ear

Gonadal Steroids, Learning, and Memory

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