Some Therapeutic Approaches to Chronic Renal Insufficiency

Bh, Scribner; Eb, Fergus; Boen, S. T.; Ed, Thomas

doi:10.1146/annurev.me.16.020165.001441

Cited by 49 publications

(5 citation statements)

References 31 publications

(39 reference statements)

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“…However, it may be associated with two major complications: the formation of fibrin clots, which may interfere with catheter function [18], and the formation of peritoneal adhesions, which may render the peritoneum unsuitable for dialysis [46]. However, it may be associated with two major complications: the formation of fibrin clots, which may interfere with catheter function [18], and the formation of peritoneal adhesions, which may render the peritoneum unsuitable for dialysis [46].…”

Section: Lnj/ammatory Responses Of the Peritoneummentioning

confidence: 99%

Peritonitis

Vas¹,

Low²,

Oreopoulos³

1981

Peritoneal Dialysis

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Section: Lnj/ammatory Responses Of the Peritoneummentioning

confidence: 99%

Peritonitis

Vas¹,

Low²,

Oreopoulos³

1981

Peritoneal Dialysis

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“…(4) Some tubular lesions cause excessive salt and water loss rather than salt and water conservation. In these patients there is a tendency for the arterial blood pressure to remain normal or to fall (39), and it is sometimes necessary to give these patients both salt and water to keep them from going into a lethal state of dehydration with a subsequent fall in pressure and death. (5) In primary aldosteronism, which is known to promote marked reabsorption of sodium from the tubules and, therefore, to cause marked reabsorption of water, only moderate hypertension occurs in the early stages, although the fluid retention effects of this condition occur from the very beginning of the disease.…”

Section: Relative Importance Of Pretubular Mechanisms Of the Kidney Vmentioning

confidence: 99%

Brief Reviews : A Systems Analysis Approach to Understanding Long-Range Arterial Blood Pressure Control and Hypertension

Guyton

Coleman

Cowley

et al. 1974

Circulation Research

306

164

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• The use of systems analysis as an experimental tool for solving complex physiological problems is not new. Actually, systems analysis is merely the logical analysis of how systems perform. However, modern usage of the term implies a more formalized type of logic, especially a type of logic that includes quantification at each step in the analysis. Several of the figures in this paper illustrate systems analysis flow diagrams that show interrelationships between the different parts of simple or complex mechanisms for the control of arterial blood pressure. One can readily see that each part of each systems analysis diagram is only a symbolic way in which a composite of individual physiological phenomena fit together in a complete system.The principal advantage of the formalized systems analysis approach to understanding any physiological mechanism is that it often allows greater depth of thought than our minds can perform using simple logical procedures. The mind has the capability of holding and analyzing perhaps five to ten different sequential phenomena, each occurring at different rates and each interrelated with the other phenomena by various cross-linkages. However, beyond this size of system it is almost impossible to think through all the complex relationships simultaneously. On the other hand, the modern computer can handle literally thousands of such crosslinking interrelationships at the same time and can develop answers that the mind alone cannot achieve. Now setting aside this philosophizing about systems analysis per se, we will attempt to show how the systems analysis approach has been useful in the study of long-range arterial blood pressure control and the understanding of hypertensive

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“…It is our intent to review these immune system abnormalities in renal fail ure and in patients on hemodialysis (HD). It is clear that HD is now a well-recognized means of prolonging life in patients with endstage renal disease [1,2]. However, HD has not solved all clinical abnormalities found in the uremic state.…”

Section: Introductionmentioning

confidence: 99%

Immune Abnormalities in Renal Failure and Hemodialysis

Kay¹,

Raij²

1986

Blood Purif

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Considerable work needs to be done in order to understand the immunosupressive effect of ‘uremia’ and the lymphocyte changes induced by hemodialysis. For example, the lymphocyte population dynamics can be further defined using monoclonal antibodies specific for lymphocyte subgroups. In vitro assays are available for lymphokine detection (i.e. IL-1, IL-2 which are important for T cell function) and may be correlated with both the clinical state and overall immunobiological status of hemodialyzed patients. The possibility of specifically delineating the extent of the immune system dysfunction in renal failure patients (on or off dialysis) is at hand. With this knowledge it will be possible to manipulate their management so as to minimize function alterations.

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Some Therapeutic Approaches to Chronic Renal Insufficiency

Cited by 49 publications

References 31 publications

Peritonitis

Peritonitis

Brief Reviews : A Systems Analysis Approach to Understanding Long-Range Arterial Blood Pressure Control and Hypertension

Immune Abnormalities in Renal Failure and Hemodialysis

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