Some Substances Derived from Ruscogenin

Nussbaum, A. L.; Carlon, F. E.; Gould, David H.; Oliveto, Eugene P.; Hershberg, E. B.; Gilmore, Marilyn; Charney, William

doi:10.1021/ja01528a052

Cited by 12 publications

(1 citation statement)

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“…In 1959 Nussbaum et al (1959) obtained 1b-hydroxylated pregnane derivatives from ruscogenin. However, the pharmacological activities of these derivatives were not explored further.…”

Section: Discussionmentioning

confidence: 99%

Comparison of anti‐inflammatory activities of ruscogenin, a major steroidal sapogenin from Radix Ophiopogon japonicus, and Its succinylated derivative, RUS‐2HS

Huang

Kou

Liu

et al. 2008

Drug Development Research

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Ruscogenin (RUS), first isolated from Ruscus aculeatus, is also a major steroidal sapogenin of the traditional Chinese herb Radix Ophiopogon japonicus. It has robust anti-inflammatory activities. In previous studies, a ruscogenin affinity column, derived from succinylated ruscogenin (RUS-2HS), was used to purify an antibody of ruscogenin. A ruscogenin affinity column can also be used to explore its protein targets. However, until now there have been no related pharmacological reports about ruscogenin derivatives. Whether the activity groups of ruscogenin have been blocked during the derivation process remains unknown. The present study was performed to compare the anti-inflammatory activities in vitro of RUS-2HS and ruscogenin. Both compounds reduced tumor necrosis factor-a (TNF-a)-induced adhesion of human pro-myelocytic leukemia cells (HL-60) to endothelial ECV304 cells with IC 50 values of 6.90 nM and 7.45 nM, respectively. They were also inhibited overexpression of ICAM-1 in ECV304 cells at the mRNA level as evaluated by real-time PCR and at the protein level evaluated by flow cytometry with similar potency. Such data demonstrate that the functional groups of ruscogenin were not blocked by derivation, suggesting further use of the ruscogenin affinity column for target investigation. Meanwhile, RUS-2HS was found to have remarkable anti-inflammatory activity for the first time, indicating it would be a new lead compound with improved bioavailability. Drug Dev Res 69: 196-202, 2008.

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“…In 1959 Nussbaum et al (1959) obtained 1b-hydroxylated pregnane derivatives from ruscogenin. However, the pharmacological activities of these derivatives were not explored further.…”

Section: Discussionmentioning

confidence: 99%

Comparison of anti‐inflammatory activities of ruscogenin, a major steroidal sapogenin from Radix Ophiopogon japonicus, and Its succinylated derivative, RUS‐2HS

Huang

Kou

Liu

et al. 2008

Drug Development Research

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Selenium Dioxide Oxidation

Rabjohn

2011

Organic Reactions

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Selenium dioxide has developed considerable stature since it was first reviewed in this series. Search for examples of oxidation by selenium dioxide or selenious acid is difficult because the terms are seldom indexed. Frequently it is difficult to decide whether selenium dioxide or selenious acid was the oxidizing agent employed in a reaction because it is impossible to determine if water was present. The determination is complex because the free acid or anhydride may react reversibly or irreversibly with various solvents such as alcohols or acids. To give selenium‐containing compounds of unknown structure which might be the real oxidizing gents. In this chapter, the practical aspects of oxidation with selenium dioxide are summarized. Mechanisms are treated in detail.

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