Some Scaling Principles for the Immune System

Abstract

Summary Using recent progress in biological scaling, we explore the way in which the immune system of an animal scales with its mass ( M ). It is shown that the number of cells in a single clone of B cells should scale as M and that the B-cell repertoire scales as ln ( cM ), where c is a constant. The time that a B cell needs to circulate once through the organism is shown to scale as M 1/4 ln ( cM ). It is suggested that the scaling of other cell populations in the immune system could be derived from these scaling relations for B cells.

An Immune System Inspired Theory for Crime and Violence in Cities

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“…Our work is based on the evolution of a multi-strain model of HIV-1 dynamics, first appearing in (Sguanci et al, 2007), which takes into account the models developed by Perelson and his followers (Chao et al, 2004;Ho et al, 1995;Perelson et al, 1996;Wiegel and Perelson, 2004). These models are well presented and take specific biological reality into account.…”

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