Some problems on health effects of polychlorinated biphenyls

Umeda, Gensyo; Nakajima, Hiroyuki; Yatsuki, Kuniko

doi:10.1016/0147-6513(78)90012-x

Cited by 10 publications

(2 citation statements)

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“…Pathological studies of the peripheral nervous system in patients with PCB exposure ha ve not come to our attention . PCB can cross the blood-brain barrier, since PCB have been detected in the brain of a stillborn baby born to a Yusho mother, and reportedly also in the brain of adult Yusho patients (17). Various central nervous system symptoms have been reported among Yusho patients (17) and among American workers occupationally exposed to PCB (14).…”

Section: Discussionmentioning

confidence: 99%

“…PCB can cross the blood-brain barrier, since PCB have been detected in the brain of a stillborn baby born to a Yusho mother, and reportedly also in the brain of adult Yusho patients (17). Various central nervous system symptoms have been reported among Yusho patients (17) and among American workers occupationally exposed to PCB (14). The subjects of the present study were exposed onl y for short periods (a few hours) although probably to a high peak exposure, and no permanent damage developed.…”

Section: Discussionmentioning

confidence: 99%

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Reversible nerve lesions after accidental polychlorinated biphenyl exposure.

Am¹,

Vuojolahti²,

O³

1985

Scand J Work Environ Health

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(1985) 91-95. Several capacitors containing polychlorinated biphenyls (PCB) exploded in a cardboard plant. During the accident, and in the clearing work, several workers were in probable contact with PCB and/or its degradation products. Nausea, intense perspiration, and headache were acute symptoms, which cleared quickly. The 15 men with the greatest exposure were studied neurophysiologically twice, namely, two and six months after the explosion. Motor conduction velocities (MCV) of the right median, ulnar, and peroneal nerves; sensory conduction velocity (SCV) of the right sural nerve; and distal SCVs of the right median and ulnar nerves were measured with skin electrodes. Thirty male workers with a similar age distribution served as referents. Two months after the explosion all SCVsand distal SCVswere slower in the exposed men, and still six months after the explosion the distal SCV of the ulnar nerve and the SCV of the sural nerve were slightly sloweramong the exposed. However, clear improvement occurred in the distal SCVs during the follow-up. As in many toxic distal axonopathies, the distal SCVs were reversibly impaired after an accidental exposure to PCB fumes. PCB seem to exhibit neurotoxic properties in humans.

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Section: Discussionmentioning

confidence: 99%