A congener analysis of polychlorinated biphenyls accumulating in rat pups after perinatal exposure

Shain, William; Overmann, Stephen R.; Wilson, Lloyd R.; Kostas, Jeanne; Bush, Brian

doi:10.1007/bf01054916

Cited by 44 publications

(12 citation statements)

References 41 publications

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“…The observed and predicted E50 values (the concentration that increases the control activity by 50%) along with their 95% confidence limits (CL) are presented in Table 2 [ (6,7,15,17,(55)(56)(57), there are no reports on the potential interactive effects of these congeners in the nervous system. Our previous structure-activity relationship studies (20,22) (26,37,58), were affected by PCB congeners that have a noncoplanar configuration (18,19,59).…”

Section: 2'44'-tecb Also Increased [3h]pdbumentioning

confidence: 99%

“…Mixture 4 is the congener's mix from human blood representing maternal exposure (6Z. Mixture 5 represents the ratio of PCB congeners detected in the brains of rats at postnatal day 21 that had been exposed to PCBs from conception to weaning via feeding dams with adulterated chow containing the commercial mixture Aroclor 1254 (55) In summary, the present data suggest that the biological effects of some PCB congeners are dose additive and that the coplanar congeners do not alter the activity of noncoplanar congeners, indicating a common mechanism for all noncoplanar congeners distinct from that of coplanar congeners. Some _,.…”

Section: 2'44'-tecb Also Increased [3h]pdbumentioning

confidence: 99%

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Interactive effects of environmentally relevant polychlorinated biphenyls and dioxins on [3H]phorbol ester binding in rat cerebellar granule cells.

Kodavanti

Ward

1998

Environ Health Perspect

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[3,3',4,] did not alter the in vitro activity of the noncoplanar (2,2',5,5'-TeCB) or coplanar [4,4'-dichlorobiphenyl (DCB)] congeners; 2) binary mixtures of active PCB congeners (2,2',4,4'-TeCB and 2,2'-DCB; 2,2'-DCB and 3,5-DCB; 2,2',3,5',6-PeCB and 2,2',4,4',5-PeCB) interact in a dose-additive manner; 3) TCDD did not alter the activity of either coplanar (3,3',4,4'-TeCB) or noncoplanar (2,2',5,5'-TeCB) congeners; 4) the interaction between the parent PCB congener and hydroxy metabolite of PCB is additive; 5) PCB congener mi at the ratios found in environmental samples are biologically active; and 6) there was no indication of synergism in any of the combinations studied. These results sugst that the biological effet of binary mixtures of PCB congeners fit a dose-additive model, indicating that there is a specific site of action for these PCB congeners which is independent of the aryl hydrocarbon receptor.

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Section: 2'44'-tecb Also Increased [3h]pdbumentioning

confidence: 99%

Section: 2'44'-tecb Also Increased [3h]pdbumentioning

confidence: 99%

Interactive effects of environmentally relevant polychlorinated biphenyls and dioxins on [3H]phorbol ester binding in rat cerebellar granule cells.

Kodavanti

Ward

1998

Environ Health Perspect

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“…The congener found at the highest concentration in samples of newborn rat brain was PCB-85. Shain et al (1986) estimated that the transfer of PCBs through the mammary gland and milk in rats may be 100 times higher than the transfer across the placenta, resulting in a higher accumulation during lactation than during pregnancy. Kodavanti et al (1998) investigated the congener-specific distribution of PCBs in blood, brain, liver, and adipose tissue of adult rats given repeated doses of Aroclor 1254 (30 mg/kg bw per day; once per day, 5 days per week for 4 weeks).…”

Section: (B) Experimental Systems (I)mentioning

confidence: 99%

“…Concentrations in milk sampled from the same group were between 16 and 25 µg/g. Samples of brain, adipose tissue, and liver from rat pups and dams exposed to Aroclor 1254 were analysed by Shain et al (1986). In adipose tissue, most congeners were detected at concentrations close to the feed concentration, but the following congeners accumulated to tissue concentrations 10-fold those in the feed: PCB-176, PCB-146, PCB-138 + PCB-168 + PCB 178 (co-eluted), and PCB-177.…”

Section: (B) Experimental Systems (I)mentioning

confidence: 99%

Polychlorinated Biphenyls and Polybrominated Biphenyls

Agudo

Aronson²,

Bonefeld-Jörgensen³

et al. 2008

Organic Pollutants

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initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, lifestyle factors and biological and physical agents, as well as those in specific occupations. The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in carcinogenesis and related fields; and to indicate where additional research efforts are needed. The lists of IARC evaluations are regularly updated and are available on the Internet at http:// monographs.iarc.fr/.This programme has been supported since 1982 by Cooperative Agreement U01 CA33193 with the United States National Cancer Institute, Department of Health and Human Services. Additional support has been provided since 1986 by the European Commission Directorate-General for Employment, Social Affairs, and Inclusion, initially by the Unit of Health, Safety and Hygiene at Work, and since 2014 by the European Union Programme for Employment and Social Innovation "EaSI" (2014-2020) The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications -whether for sale or for non-commercial distribution -should be addressed to the IARC Communications Group at: publications@iarc.fr.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.The IARC Monographs Working Group alone is responsible for the views expressed in this publication. IARC Library Cataloguing in Publication Data NOTE TO THE READERThe term 'carcinogenic risk' in the IARC Monographs series is taken to mean that an agent is capable of causing cancer. The Monographs evaluate cancer hazards, despite the historical presence of the word 'risks' in the title.Inclusion of an agent in the Monographs does not imply that it is a carcinogen, only that the published data have been examined. Equally, the fact that an agent has not yet been evaluated in a Monograph does not mean that...

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“…PCBs have shown to be well absorbed from the gastro-intestinal tract of rats [1]. Moreover, PCBs have been reported to be transferred through the placenta to fetus and via milk to the neonate [2,7,16], with greater transfer occurring during lactation than gestation, at least in humans [16] and rats [30].…”

mentioning

confidence: 99%

Effects of Exposure of Lactating Female Rats to Polychlorinated Biphenyls(PCBs) on Testis Weight, Sperm Production and Sertoli Cell Numbers in the Adult Male Offspring.

Kim

2001

The Journal of Veterinary Medical Science

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ABSTRACT. To investigate the effects of intermittent and continuous exposure of lactating rats to Aroclor 1242 (a PCB congener), testis weight, daily sperm production (DSP) and Sertoli cell number per testis were examined in the adult male offspring. Thyroxine (T 4 ) was also measured because of the well-documented effects of polychlorinated biphenyls (PCBs) on this hormone. In experiment I, 3 groups of lactating female rats received daily subcutaneous injections of low (0.8 mg) or high (1.6 mg) doses of Aroclor 1242 in 0.1 ml corn oil from parturition to weaning of pups at 21 days. In experiment II, 3 groups of lactating rats received 2 subcutaneous injections per week of 0.8 or 1.6 mg Aroclor 1242, as in experiment I. In both experiments, control rats received vehicle alone. Serum T 4 was measured at 21 and 90 days of age, and testis weight, DSP and Sertoli cell numbers were examined at 90 days. In experiment I (continuous exposure), both the low (0.8 mg) and high (1.6 mg) doses suppressed T 4 concentrations at 21 days of age. Testis weight was increased by 14.8% (LD) and 16.5% (HD) compared with controls. DSP was increased by 20.4% in the low dose and 25% in the high dose animals compared with controls. The number of Sertoli cells per testis was increased by 32.6 and 39.4% in low and high dose animals, respectively. A similar study in which the lactating females were only dosed twice per week (experiment II) did not show any differences in these parameters. These results indicate that continuous exposure of lactating female rats to PCBs increases testis weight, sperm production and Sertoli cell numbers in the adult male offspring.

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A congener analysis of polychlorinated biphenyls accumulating in rat pups after perinatal exposure

Cited by 44 publications

References 41 publications

Interactive effects of environmentally relevant polychlorinated biphenyls and dioxins on [3H]phorbol ester binding in rat cerebellar granule cells.

Interactive effects of environmentally relevant polychlorinated biphenyls and dioxins on [3H]phorbol ester binding in rat cerebellar granule cells.

Polychlorinated Biphenyls and Polybrominated Biphenyls

Effects of Exposure of Lactating Female Rats to Polychlorinated Biphenyls(PCBs) on Testis Weight, Sperm Production and Sertoli Cell Numbers in the Adult Male Offspring.

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