Some Physico-Chemical Properties of Low Molecular Weight Chitosans and their Relationship to Conformation in Aqueous Solution

Obaidat, Rana; Al-Jbour, Nawzat; Al-So'ud, Khaldoun A; Sweidan, Kamal; Al-Remawi, Mayyas; Badwan, Adnan A.

doi:10.1007/s10953-010-9517-x

Cited by 35 publications

(21 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FTIR of chitosan oligomers matched with reported results of Obaidat et al [24]. Free amine vibrations occurred in the 1650-1590 cm −1 region while amine salt vibrations occur in the 1600-1400 cm −1 region.…”

Section: Discussion Physicochemical Characterization Of Chitosansupporting

confidence: 89%

“…The first stage which usually ranges from 25 to 147°C is related to water evaporation, as previously reported [20][21][22]30]. It has been reported that the delay in the loss of water to above 100°C is due to the hydrogen bonds between chitosan and the water molecules [31], while the second stage (≥175°C) comes from polymer decomposition [24].…”

Section: Discussion Physicochemical Characterization Of Chitosanmentioning

confidence: 67%

“…The first endothermic peak represents water evaporation [20][21][22][23], and the second exothermic peak is related to the decomposition temperature, which was 311°C for raw chitosan and was around 202.8°C for the oligomers [24]. This indicates that raw chitosan is more stable than the chitosan oligomers.…”

Section: Discussion Physicochemical Characterization Of Chitosanmentioning

confidence: 99%

“…Low molecular weight chitosan oligomers were prepared as reported by Obaidat et al [24]. The reaction time was either 2 or 6 h to obtain either 16 or 8 kDa oligomers, respectively [23].…”

Section: Preparation Of Chitosan Microparticles Using Sfc Technology mentioning

confidence: 99%

See 3 more Smart Citations

Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

et al. 2015

View full text Add to dashboard Cite

Abstract. Supercritical fluid technology offers several advantages in preparation of microparticles. These include uniformity in particle size, morphology, and drug distribution without degradation of the product. One of the recent advantages is preparation of porous aerogel carrier with proper aerodynamic properties. In this study, we aimed to prepare chitosan aerogel microparticles using supercritical fluid (SCF) technology and compare that with microparticles produced by freeze drying (FD). Loading the prepared carriers with a model drug (salbutamol) was also performed. Comparisons of the particle properties and physicochemical characterizations were undertaken by evaluating particle size, density, specific surface area, and porosity. In vitro drug release studies were also investigated. The effect of many variables, such as molecular weight of chitosan oligomers, concentrations of chitosan, and concentrations of tripolyphosphate on the release, were also investigated. Chitosan aerogels were efficiently produced by SCF technology with an average particle size of 10 μm with a tapped density values around 0.12 g/mL, specific surface area (73-103)m 2 /g, and porosity (0.20-0.29)cc/g. Whereas, microparticles produced by FD method were characterized as cryogels with larger particle size (64 microns) with clear cracking at the surface. Sustained release profile was achieved for all prepared microparticles of salbutamol produced by the aforementioned methods as compared with pure drug. The results also demonstrates that chitosan molecular weight, polymer concentration, and tripolyphosphate concentration affected the release profile of salbutamol from the prepared microparticles. In conclusion, SCF technology was able to produce chitosan aerogel microparticles loaded with salbutamol that could be suitable for pulmonary drug delivery system.

show abstract

Section: Discussion Physicochemical Characterization Of Chitosansupporting

confidence: 89%

Section: Discussion Physicochemical Characterization Of Chitosanmentioning

confidence: 67%

Section: Discussion Physicochemical Characterization Of Chitosanmentioning

confidence: 99%

“…Low molecular weight chitosan oligomers were prepared as reported by Obaidat et al [24]. The reaction time was either 2 or 6 h to obtain either 16 or 8 kDa oligomers, respectively [23].…”

Section: Preparation Of Chitosan Microparticles Using Sfc Technology mentioning

confidence: 99%

See 2 more Smart Citations

Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Chitosan was prepared as Obeidat et al (2010) to prepare two different molecular weights (chitosan 16 and chitosan 11 kDa). Further crosslinking was performed according to obaidat et al [13]. Table 1 summarizes the prepared SDs showing the different drug: polymer ratios and the methods used for preparation.…”

Section: Methodsmentioning

confidence: 99%

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Obaidat

Al-Taani

Al-quraan

2017

Int J Pharm Pharm Sci

Self Cite

View full text Add to dashboard Cite

Objective: Meloxicam is classified as class II corresponding to its high permeability and low solubility (12μg/ml). This study aims to compare the effect of selected polymers on stabilization of amorphous form, and dissolution of meloxicam by preparation of different solid dispersions using selected polymers (chitosan oligomers, polyvinylpyrrolidone K30, and polyethylene glycols).Methods: These solid dispersions were prepared using two different methods; solvent evaporation method for the two molecular weights chitosan carriers (16 and 11KDa) and polyvinylpyrrolidone-K30 and melting method for the two different molecular weights polyethylene glycol (4000 and 6000). The physicochemical properties of solid dispersions were analyzed using differential scanning calorimetry, Fourier transform infra-red analysis, Powder X-ray diffraction, and scanning electron microscopy. Selected dispersions were then compared to two selected marketed drugs (Mobic® and Moven®).Results: Best dissolution rates were obtained for both polyvinylpyrrolidone-K30 and polyethylene glycol 6000, followed by chitosan 16 kDa, chitosan 11 kDa, and polyethylene glycol 4000. Increasing polymeric ratio increased dissolution rate except for chitosan. Precipitation of the drug as amorphous form occurred in chitosan and polyvinylpyrrolidone-K30 dispersions, while no change in crystallinity obtained for polyethylene glycol dispersions. Failure of polyvinylpyrrolidone-K30 in the maintenance of stability during storage time was observed while re-crystallization occurred in chitosan-based dispersions, which ends with preferences to polyethylene glycol dispersions. After comparing the release of selected dispersions with the two selected polymers; all dispersions got a higher release than that of the two marketed drugs release. Conclusion:The dissolution profile of meloxicam has been increased successfully in a reproducible manner.

show abstract

Chitosan Application in Textile Processing and Fabric Coating

Hahn¹,

Bossog²,

Hager³

et al. 2019

Chitin and Chitosan

View full text Add to dashboard Cite

Some Physico-Chemical Properties of Low Molecular Weight Chitosans and their Relationship to Conformation in Aqueous Solution

Cited by 35 publications

References 26 publications

Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

Effect of Selected Polymers on Dissolution and Stabilization of Amorphous Form of Meloxicam

Chitosan Application in Textile Processing and Fabric Coating

Contact Info

Product

Resources

About