Some organoboron compounds containing a bis(2-chloroethyl)amino group joined to boron

Yf, Shealy; Rf, Struck

doi:10.1021/jm00305a046

Cited by 8 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Trivalent boron compounds are well known to be electron deficient and behave as Lewis acid [16]. The intramolecular pyridine nitrogen could serve as electron donor and form stable complex as indicated in structure 4 ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and evaluation of unsymmetrical difluoro‐boron complexes with imidazoline as potential fungicides

Wang

Cui

Xie

et al. 2009

Heteroatom Chemistry

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and evaluation of unsymmetrical difluoro‐boron complexes with imidazoline as potential fungicides

Wang

Cui

Xie

et al. 2009

Heteroatom Chemistry

View full text Add to dashboard Cite

show abstract

“…Soloway and Butler synthesized 4-[bis(2-carboroethyl)amino]phenylcarborane 17 and boron-containing acridines 18 which were tested in vivo in mouse ependymoma tumors. Shealy and Struck 19 prepared bis(2-chloroethyl)amino analogues which were tested against rat Walker 256 carcinosarcoma and mouse L1210 lymphoid leukemia growth. These derivatives were also active in vitro in the KB nasopharynx and H. Ep-2 larynx carcinoma cytotoxic screens.…”

Section: Introductionmentioning

confidence: 99%

The cytotoxicity of trifluoromethyl boron derivatives and mode of action in human Tmolt3 T leukemic cells

Hall

Henry

Peaty

et al. 2000

Appl. Organometal. Chem.

View full text Add to dashboard Cite

Trifluoromethylboron derivatives proved to be cytotoxic in a number of murine and human leukemic and lymphoma screens. Solid tumor growth, e.g. glioma HS 683, breast Mck‐7 and colon adenocarcinoma SW480, was reduced significantly by the compounds. Human Tmolt3 T‐cell leukemia DNA synthesis was inhibited preferentially by the derivatives, with marginal effects on RNA and protein syntheses, after 60 min at 100 µM. The agents appeared to act by multiple mechanisms in that they inhibited the activities of DNA polymerase α, dihydrofolate reductase and nucleosides, significantly within 60 min at 100 µM. Deoxyribonucleotide pools were reduced after 60 min incubation with the compounds. Tmolt3 DNA fragmentation and reduced ct‐DNA viscosity were evident after 24 h of incubation at 100 µM. ct‐DNA thermal denaturation studies indicated that the agents caused some type of interaction with the bases of DNA. Copyright © 2000 John Wiley & Sons, Ltd.

show abstract

Novel buron heterocycles. I. 2,3‐dihydro‐1,3,2‐benzodiazaborin‐4(III)‐ones and 1,2‐dihydro‐ 1,3,2‐benzodiazaborines

Yale¹

1971

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

A series of 2,3‐dihydro‐1,3,2‐benzodiazaborin‐4(IH)‐ones have been prepared and their ir spectra compared with those of their carbon isosteres. Solvolysis of these boron compounds in ethanol has been followed by uv and reveals a relationship between structure and rates of ethanol‐ysis. Unexpectedly, these boron heterocycles, in contrast to their carbon isosteres, dissolve in aqueous alkali to form stable anions and the significance of this is discussed. The 1 :1 adducts of 1 and phosphorus oxychloride has been utilized to prepare two derivatives of the very stable 1,2‐dihydro‐2‐phenyl‐1,3,2‐benzodiazaborin heterocycle.

show abstract

Some organoboron compounds containing a bis(2-chloroethyl)amino group joined to boron

Abstract: Table III N-(

Cited by 8 publications

References 0 publications

Design, synthesis, and evaluation of unsymmetrical difluoro‐boron complexes with imidazoline as potential fungicides

Design, synthesis, and evaluation of unsymmetrical difluoro‐boron complexes with imidazoline as potential fungicides

The cytotoxicity of trifluoromethyl boron derivatives and mode of action in human Tmolt3 T leukemic cells

Novel buron heterocycles. I. 2,3‐dihydro‐1,3,2‐benzodiazaborin‐4(III)‐ones and 1,2‐dihydro‐ 1,3,2‐benzodiazaborines

Contact Info

Product

Resources

About