Some Observations on the Epidemiology of Breast Cancer Among Males

Schottenfeld, David; Lilienfeld, Abraham M.; Diamond, Henry D.

doi:10.2105/ajph.53.6.890

Cited by 79 publications

(49 citation statements)

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“…Breast carcinoma has also been observed to be more common among American Jewish men, a population of predominantly Ashkenazi origin, compared to other non-Jewish Americans. (5)(6)(7)(8) The functionally defective mutations of BRCA1 and BRCA2 are associated with increased breast cancer risk; however, such mutations are relatively rare in unselected cancer patients. The frequency of three founder germline mutations in the tumor suppressor genes BRCA1 and BRCA2 among unselected Ashkenazi women with breast cancer is roughly 10%, and is much higher in multiple-case families.…”

Section: Introductionmentioning

confidence: 99%

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Chodick

Struewing

Ron

et al. 2008

European Journal of Medical Genetics

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To evaluate the potential contribution of mutations in the BRCA1 and BRCA2 genes to male breast cancer (MBC), we expanded a previous study to screen a total of 261 Israeli men diagnosed with breast carcinoma. A total of 21 BRCA2 6174delT and eight BRCA1 185delAG mutations were found. Similar frequencies of BRCA1 and BRCA2 mutation carriers were found among Ashkenazi (12.8%) and non-Ashkenazi Jews (9.1%). The combined prevalence of BRCA1/BRCA2 founder mutations among Ashkenazi Jewish men is slightly higher than for women, due to a higher frequency of BRCA2 mutations.

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Section: Introductionmentioning

confidence: 99%

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Chodick

Struewing

Ron

et al. 2008

European Journal of Medical Genetics

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“…Prostatic carcinoma is less common in patients with cirrhosis than in non-cirrhotics, this being attributed to hyperoestrogenism (Glantz, 1964). However, Robson (1966) (Jackson et al, 1965) and orchitis (Schottenfeld et al, 1963)). Relatively high frequencies of male breast carcinoma (El Gazayerli & Abdel-Aziz, 1963;Sherif et al, in press) and a low frequency of prostatic carcinoma (Sherif et al, in (Waterhouse et al, 1976) (see Figure).…”

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confidence: 99%

Relation between male breast cancer and prostate cancer

Sobin¹,

Sherif²

1980

Br J Cancer

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“…It has been demonstrated that Klinefelter syndrome carriers have a higher risk of developing breast cancer [4,13] . Although the mechanisms underlying the higher susceptibility to breast cancer in Klinefelter syndrome are not well known, it seems possible that X chromosome gain may play a role in the neoplastic transformation of the male breast epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

X chromosome gain in male breast cancer

et al. 2015

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Male breast cancer (MBC) is an uncommon disease whose molecular profile is not well known. X chromosome gain has been described as a marker of aggressive behavior in female breast cancer. The aim of this study is to investigate the role of the X chromosome in male breast cancer. Twenty cases of male breast invasive ductal carcinoma were retrieved and compared with 10 cases of gynecomastia. Cases were tested by fluorescence in situ hybridization to assess a cytogenetic profile for the X chromosome. The X chromosome status was compared with histopathologic features and stage at presentation. All MBC cases harbored an X chromosome gain (100%) in a variable percentage of neoplastic cells, ranging from 31% to 85% (mean, 59%). On the contrary, all cases of gynecomastia showed wild X chromosome asset. The patients' age at surgery and tumor grading showed a statistically significant correlation (P = .0188-.04), with the percentages of neoplastic cells showing an X chromosome gain. These data suggest that this X chromosome gain plays a role in the neoplastic transformation of male breast epithelial cells. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. These data suggest that this X chromosome gain plays a role in the neoplastic transformation of male breast epithelial cells. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT X CHROMOSOME GAIN IN MALE BREAST CANCER

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Some Observations on the Epidemiology of Breast Cancer Among Males

Abstract: Cancer of the male breast is a rare disease. Mortality data for this condition were reviewed and certain observations on age-specific rates were made. Furthermore, the specificity of association with a number of factors of epidemiological interest were critically evaluated.

Cited by 79 publications

References 10 publications

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: Evidence from 261 cases in Israel, 1976–1999

Relation between male breast cancer and prostate cancer

X chromosome gain in male breast cancer

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