SOME OBSERVATIONS ON THE ANORECTIC ACTIVITY OF PROSTAGLANDIN F<sub>2α</sub>

Doggett, N.S.; Jawaharlal, K.

doi:10.1111/j.1476-5381.1977.tb07516.x

Cited by 12 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is somewhat surprising considering that PGD 2 has been reported to stimulate appetite . Of the prostaglandins that have been reported to have anorexigenic properties (PGE 1 , PGF 1α , PGF 2α , PGA 1 , and PGB 1 ; , PGF 2α appears the most studied (Doggett and Jawaharlal, 1977;. However, two observations argue against a role for PGF 2α in cancer-induced anorexia.…”

Section: Discussionmentioning

confidence: 58%

“…However, two observations argue against a role for PGF 2α in cancer-induced anorexia. Firstly, the appetite suppressing effect of PGF 2α is short-lived (possibly lasting ~ 180 min), especially when delivered peripherally (15-30 min; (Doggett and Jawaharlal, 1977), and, secondly, PGF 2α activates muscle protein synthesis , which is quite different to the muscle wasting that is characteristic for cachexia. sham-implanted mice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

Ruud¹,

Nilsson²,

Ruud³

et al. 2013

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

, Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1, 2013, Brain, behavior, and immunity, (29) AbstractIt is well-established that prostaglandins (PGs) affect tumorigenesis, and evidence indicates that PGs also are important for the reduced food intake and body weight loss, the anorexiacachexia syndrome, in malignant cancer. However, the identity of the PGs and the PG producing cyclooxygenase (COX) species responsible for cancer anorexia-cachexia is unknown. Here, we addressed this issue by transplanting mice with a tumor that elicits anorexia. Meal pattern analysis revealed that the anorexia in the tumor-bearing was due to decreased meal frequency. Treatment with a non-selective COX inhibitor attenuated the anorexia, and also tumor growth. When given at manifest anorexia, non-selective COXinhibitors restored appetite and prevented body weight loss without affecting tumor size.Despite COX-2 induction in the cerebral blood vessels of tumor-bearing mice, a selective COX-2 inhibitor had no effect on the anorexia, whereas selective COX-1 inhibition delayed its onset. Tumor growth was associated with robust increase of PGE 2 levels in plasma -a response blocked both by non-selective COX-inhibition and by selective COX-1 inhibition, but not by COX-2 inhibition. However, there was no increase in PGE 2 -levels in the cerebrospinal fluid. Neutralization of plasma PGE 2 with specific antibodies did not ameliorate the anorexia, and genetic deletion of microsomal PGE synthase-1 (mPGES-1), affected neither anorexia nor tumor growth. Furthermore, tumor-bearing mice lacking EP 4 receptors selectively in the nervous system developed anorexia. These observations suggest that COXenzymes, most likely COX-1, are involved in cancer-elicited anorexia and weight loss, but that these phenomena occur independently of host mPGES-1, PGE 2 and neuronal EP 4 signaling.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

Ruud¹,

Nilsson²,

Ruud³

et al. 2013

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

show abstract

“…intragastric. Furthermore, induction of similar pain with acetic acid does not affect food intake (Doggett & Jawaharlal, 1977). Since these fatty acids do not cause pyrexia an elevation of body temperature can also be excluded as a cause of anorexia.…”

Section: Resultsmentioning

confidence: 99%

“…Since the first report (Horton, 1964), their possible involvement in the regulation of the hunger-satiety phenomenon has been studied by a number of workers (for references see Doggett & Jawaharlal, 1977). It has been shown that in man, fasting is associated with lower prostaglandin levels in the blood as compared with post-prandial samples (Greaves, McDonaldGibson & McDonald-Gibson, 1972).…”

Section: Introductionmentioning

confidence: 99%

Anorectic Activity of Prostaglandin Precursors

Doggett

Jawaharlal

1977

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

1 Intraperitoneal and intragastric (i.g.) administration of prostaglandin precursors arachidonic (2 mg, 15 mg/kg, i.p.; 30 mg/kg, i.g.), linolenic (100 mg/kg, i.p.; 200 mg/kg, i.g.) and linoleic (15, 100 mg/kg, i.p.; 100 mg/kg, i.g.) acids to 22 h food‐deprived rats inhibits food intake. 2 This anorexia is similar to that induced by prostaglandin F2α (1 mg/kg, i.p.). 3 At anorectic doses these fatty acids do not cause pyrexia, in fact arachidonic acid causes hypothermia. 4 Prior treatment with indomethacin (15 mg/kg) and paracetamol (50 mg/kg) specifically reverses the anorexia and the behavioural satiety induced by the three fatty acids, while not affecting prostaglandin F2α‐induced suppression of food intake. 5 Results of the present experiments suggest that both physiological and pharmacological modification of appetite could be brought about through an effect on prostaglandin generating systems.

show abstract

“…The answer to this is not obvious, since the prostanoids reported to have anorexigenic properties are not that well characterized. The prostanoid that is the best characterized in regard to its anorexigenic properties is PGF2α [191,192]. However, the anorexigenic properties of PGF2α are short lived [192], and this prostanoid has also been shown to be involved in muscle anabolism [193], which is in sharp contrast to the muscle wasting seen during cachexic disease states.…”

Section: The Onset Of Cancer-induced Anorexia Is Cox-1 Dependent But mentioning

confidence: 89%

Mechanisms Behind Illness-Induced Anorexia

Nilsson¹

2016

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Loss of appetite is together with fever and malaise hallmarks of infection. Loosing appetite during an acute infection such as influenza does not result in any long-lasting effects, but loosing appetite during chronic diseases such as cancer or AIDS constitutes a risk factor for mortality. Food intake regulation during inflammation is orchestrated by the brain in response to peripheral inflammatory signals. It is known that expression of the prostaglandin synthesizing enzyme cyclooxygenase 2 (COX-2) is crucial for the mechanisms underlying inflammation-induced anorexia, and that prostaglandin E2 (PGE2) is involved in anorexia induced by interleukin-1 beta (IL-1β). In this thesis I examined the prostaglandin pathways proposed to be involved in anorexia. We show that acute anorexia is dependent on COX-2 expression, while cancer-induced anorexia is mediated by cyclooxygenase 1 (COX-1), at least in the initial stages, suggesting that the signaling pathways for chronic-and acute anorexia are distinct. We were able to demonstrate that the pathway underlying acute anorexia is distinct from that of fever, and that taste aversion is prostaglandin independent. We could also show that both acute and chronic anorexia-cachexia is dependent on expression of myeloid differentiation primary response gene (MyD88) in hematopoietic/myeloid cells. De generella slutsatser vi kan dra av studierna som ligger till grund för denna avhandling är att symptomen som vi upplever när vi blir sjuka, och som länge har ansetts ha samma bakomliggande signalvägar, till stor del signaleras till hjärnan på olika sätt. Aptitförlusten som uppkommer vid en infektion är inte alls lika beroende av ett specifikt prostaglandin, prostaglandin E2, som man tidigare trott, men en viktig faktor för att utveckla aptitförlust både vid akut-och kronisk sjukdom verkar vara MyD88-signallering i kroppens immunceller.Att kartlägga hur dessa signalvägar fungerar och vad som skiljer olika sjukdomssymptom åt är av stor vikt för utvecklingen av nya läkemedel. Dagens receptfria anti-inflammatoriska läkemedel är visserligen effektiva, men påverkar många av kroppens homeostatiska processer. Det är därför vanligt med allvarliga biverkningar såsom nedsatt hjärtfunktion och ökad risk för stroke och hjärtinfarkt, påverkan på njurfunktionen och magsår vid kronisk användning av dessa preparat. Önskvärt vore om det fanns läkemedel som endast påverkade de processer som missgynnar välmående.

show abstract

SOME OBSERVATIONS ON THE ANORECTIC ACTIVITY OF PROSTAGLANDIN F_2α

Cited by 12 publications

References 30 publications

Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

Anorectic Activity of Prostaglandin Precursors

Mechanisms Behind Illness-Induced Anorexia

Contact Info

Product

Resources

About

SOME OBSERVATIONS ON THE ANORECTIC ACTIVITY OF PROSTAGLANDIN F2α

Cited by 12 publications

References 30 publications

Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1

Anorectic Activity of Prostaglandin Precursors

Mechanisms Behind Illness-Induced Anorexia

Contact Info

Product

Resources

About

SOME OBSERVATIONS ON THE ANORECTIC ACTIVITY OF PROSTAGLANDIN F_2α