Some Novel Antibacterial Macrocyclic Complexes for Gram +ve and Gram -ve Bacteria

Abstract

The synthesis, characterization and antimicrobial properties of some novel macro-cyclic complexes with molecular formula [M (C 22 H 16 N 4 O 2 )X]X 2 have been discussed here, where M=Fe (III), Co (III) and Cr (III) and X is either bromine or chlorine. These complexes were prepared by template condensation of Ethylenediamine and 2, 2-dihydroxyindane-1, 3-dione using salts of trivalent metal. The complexes were characterised by physico-chemical techniques such as elemental analysises, molar conductivity, electronic spectra, magnetic moments, mass spectra and IR spectra at CFL, SAIF, Panjab University, Chandigarh. X-ray diffraction data obtained indicates the square pyramidal geometry of Cr(III), Cu (III) and Fe (III) macrocyclic complexes. Thermal stability was determined using the thermogravimetric studies. Agar well diffusion technique was used to check the antimicrobial properties of the prepared macro-cyclic complexes against two Gram +ve Bacteria and two Gram -ve Bacteria. The antimicrobial data on comparison with standard antibiotics such as streptomycin and chloramphenicol supports the antimicrobial behaviour of the above reported cobalt bromide and chromium chloride complexes.