Some new food for thought: The role of vitamin D in the mental health of older adults

Cherniack, E. Paul; Troen, Bruce R.; Flórez, Hermes; Roos, Bernard A.; Levis, Silvina

doi:10.1007/s11920-009-0003-3

Cited by 65 publications

(48 citation statements)

References 52 publications

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“…The findings are consistent with the vasculoprotective mechanisms of vitamin D [350]. However, so far, the studies are too few and inconsistent to provide any conclusive answers [349,350].…”

Section: 21supporting

confidence: 75%

“…The role of vitamin D deficiency has been proposed for dementia and Alzheimer's disease [347,349]. Positive associations between vitamin D levels and executive functions have been found, indicating the role of the vitamin in subcortical health.…”

Section: 21mentioning

confidence: 99%

“…All brain cells have VDRs, implying that vitamin D is involved in brain functions. It activates receptors on neurons in regions implicated in the regulation of behaviour, stimulates neurotrophin release, and protects the brain by buffering antioxidant and anti-inflammatory defences against vascular injury and improving metabolic and cardiovascular function [349]. Cognitive impairment is often the first sign of approaching dementia.…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

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Solar radiation and human health

Moan

Juzeniene

2010

Journal of Photochemistry and Photobiology B: Biology

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The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression, photoageing, photocarcinogenesis, cataracts and photokeratitis. However, Sun exposure is also beneficial, since moderate doses give beneficial physiological effects: vitamin D synthesis, reduction of blood pressure and mental health. Shortage of Sun exposure may be even more dangerous to human health than excessive exposure. Avoiding Sun exposure leads to vitamin D deficiency which is associated not only with rickets and osteomalacia, but also with increased risk of cardiovascular disease, multiple sclerosis, rheumatoid arthritis, diabetes, influenza, many types of cancer and adverse pregnancy outcomes. Solar radiation induces nitric oxide release in tissue and immediate pigment darkening which certainly play important roles, although these are still unknown. Action spectra relevant for health are described. We will also review what is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue.

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Section: 21supporting

confidence: 75%

Section: 21mentioning

confidence: 99%

Section: Autoimmune Diseasesmentioning

confidence: 99%

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Solar radiation and human health

Moan

Juzeniene

2010

Journal of Photochemistry and Photobiology B: Biology

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“…The positive effect of vitamin D intake (either oral rout or from the skin, or both) on the improvement of depression can be explained by several biological mechanisms which improve the functions of the neuroendocrine and central nervous systems (22) which may regulate neurotransmitters, neuroprotection, and stress hormones (23). Interestingly, insignificant difference in the depression level of the two exercise groups (indoor vs outdoor without Vitamin D supplement) demonstrates the positive effects of exercise in improving depression, in other words, both types of exercise environments were sufficient to reduce symptoms of depression.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D supplement and Indoor Vs Outdoor Physical Activity on Depression of Obese Depressed Women

Irandoust

Taheri

2017

Asian J Sports Med

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Objective: Since the rate of depression and Vitamin D deficiency has been reported in Iranian obese women, it needs to be considered seriously by researchers. Therefore, the aim of this research was to investigate the effect of vitamin D supplement (VD) and indoor physical activity (IPA) vs outdoor physical activity (OPA) on the depression of obese depressed women. Methods:This was a prospective study with 75 women (mean age: 43.5 ± 12.8 years, with body mass index (BMI) ranging from 30.0 to 35.0 kg/m 2 ). They were randomly assigned into four experimental groups who either did indoor or outdoor physical activity with or without Vitamin D. Depressive symptoms were assessed with the Beck depression inventory. The intervention group (indoor and outdoor physical activity with vitamin D) was administered a 2,000 IU Vitamin D per day for 12 weeks. The training program included warming-up, main protocol (treadmill versus outdoor jogging) and cooling-down four times a week for 3 months.Results: The results indicated that the level of depression in OPA + VD group was improved from severe (33.26 ± 2.12) to mild (16.73 ± 1.38) suggesting 50% improvement in depression score (P = 0.001) and there was, also, a significant improvement in the depression level of IPA+VD, OPA, and IPA groups from sever to moderate level in depression scores (P = 0.001).Conclusions: Both vitamin D and exercise (especially outdoor) have positive effects on depressive symptoms of depressed obese women. As a result, promotion of an active outdoor lifestyle and having sufficient Vitamin can counteract vitamin D deficiency and the rate of depression in this vulnerable population.Keywords: Vitamin D, Indoor, Outdoor, Depression BackgroundTodays, obesity and depression are two major public health problems. It has been reported that depression prevalence is more in obese people compared to those who are not obese up to 25 percent. On the other hand, there is a link between obesity with depression and lower levels of serum 25-hydroxyvitamin D. The prevalence of vitamin D deficiency (1), depression (2), and obesity (3) has increased rapidly in Iran during the past decade (4). Recently, the positive effect of vitamin D on the prevention and the treatment of mental health problems such as depression has been well documented (4). Divergent results have been reported concerning the relationship between Vitamin D and depression in such a manner that some cross sectional studies have found a relationship between low levels of serum 25-hydroxyvitamin D and depressive symptoms (5, 6); whereas other studies of similar design have found no such relationship (7). A study conducted in Saudi Arabia showed that deficient levels of Vitamin D were found in women which made them vulnerable to serious health problems, in spite of living in one of the sunniest countries in the world (8). Furthermore, in a study undertaken in Jordan, 83.3% of women wearing the most covering style of Islamic dresses were found to be deficient in summer time. This is rather striking whe...

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“…Annweiler C et al (10) suggested that Vitamin D possibly helps in the regulation of neurotransmission, neuroprotection, neuroimmumodulation, and nerve growth factor synthesis. 1,25 (OH)2D the active molecule of vitamin D has been shown to increase the production of tyrosine hydroxylase, an enzyme which is important in synthesis of norepinephrine, potentially involved in depression (11) . Ganji V et al (12) conducted a cross sectional study including 7970 US residents ageing 15-39 yrs.…”

Section: Introductionmentioning

confidence: 99%

Co-Relation between Vitamin D Levels and Hamilton Depression Scores in Patients with Depression

Husain¹

2017

JMSCR

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Some new food for thought: The role of vitamin D in the mental health of older adults

Cited by 65 publications

References 52 publications

Solar radiation and human health

Solar radiation and human health

The Effect of Vitamin D supplement and Indoor Vs Outdoor Physical Activity on Depression of Obese Depressed Women

Co-Relation between Vitamin D Levels and Hamilton Depression Scores in Patients with Depression

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