Some haematological parameters in Human Immunodeficiency Virus (HIV) infected Africans: the Nigerian perspective

Erhabor, O; Ejele, OA; Nwauche, CA; Buseri, FI

doi:10.4314/njm.v14i1.37132

Cited by 43 publications

(57 citation statements)

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“…38 Our study shows that HAART naïve patients have significantly higher value (p < 0.05) of WBC when compared to HAART patients and controls subjects. This is in agreement with works of 39,40 who in their studies observed an increase in WBC in HIV subjects. White Blood Cell (WBC) count is important to monitor because the elevation of WBC may indicate infection, lack of response to treatment or an abnormality.…”

Section: Cd4 Counts and Some Haematological Parameters Of Hiv Positivsupporting

confidence: 82%

“…Thus, HIV patients who were on HAART had a greater number of blood cells within six months of beginning treatment and hematological disorders were corrected. 46 The present study shows that patients on HAART had statistically significant increase in WBC compared to their HAART-naïve counterparts. This study shows that CD4 cell counts of patients on HAART were significantly higher compared to HAARTnaïve, this study supports the fact that HAART resulted in the significant increase in CD4 T cell counts in the majority of patients.…”

Section: Cd4 Counts and Some Haematological Parameters Of Hiv Positivmentioning

confidence: 53%

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Profile of Micronutrients, Electrolytes, Haematology and CD4 Count in HIV Infected Subjects on Highly Active Antiretroviral Therapy

Ugbeni¹,

Eruotor²

2018

TJNPR

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Section: Cd4 Counts and Some Haematological Parameters Of Hiv Positivsupporting

confidence: 82%

Section: Cd4 Counts and Some Haematological Parameters Of Hiv Positivmentioning

confidence: 53%

Profile of Micronutrients, Electrolytes, Haematology and CD4 Count in HIV Infected Subjects on Highly Active Antiretroviral Therapy

Ugbeni¹,

Eruotor²

2018

TJNPR

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“…Among these hematologic disorders, anemia is the most common hematologic manifestation (2,4,5). In different studies, the prevalence of anemia in individuals with AIDS has been reported at 63% to 95%, making it more common than thrombocytopenia or leukopenia in AIDS patients (6).…”

Section: Introductionmentioning

confidence: 99%

“…Hematologic abnormalities, which involved all lineages of blood cells and include anemia, leukopenia as well as thrombocytopenia, are among the most common complications of HIV infection (1)(2)(3). Among these hematologic disorders, anemia is the most common hematologic manifestation (2,4,5).…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS

Shen

Wang

et al. 2015

BST

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“…These anomalies may be due to various inflammatory mechanisms of HIV infection and secondary effects of ART and of treatments for opportunistic infections. Beuzit et al [8] found rates of 74% for anaemia, 20% for neutropenia and 15% for thrombopenia in central Africa, and Erhabor et al [23] found rates of 80%, 24% and 10%, respectively, in Nigeria. The high frequency of anaemia in these two studies was measured before initiation of treatment.…”

Section: Discussionmentioning

confidence: 99%

Biological Profile of HIV-Positive Patients in Bangui, Central African Republic, in 2017

Nyasenu¹,

Farra²,

Yambiyo³

et al. 2018

WJA

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Background: The biological profile of HIV-positive patients is essential for diagnosing treatment failure and the prognosis of infection. We determined the virological and immunological profiles and biological anomalies of HIV-positive people on antiretroviral therapy (ART) in Bangui, Central African Republic. Methods: We conducted an analytical, descriptive study between 4 April and 30 September 2017 of all patients who had received ART for more than 12 months and who attended the Medical Analysis Laboratory of the Institut Pasteur in Bangui for a complete biological work-up, including viral load. A blood sample was taken for quantification of RNA HIV-1, CD4 lymphocytes and blood count in two tubes containing ethylenediamine tetraacetic acid, and another sample was taken in a dry tube for measurement of creatinine and transaminases. Results: The total population comprised 1748 patients, with a mean age of 38.7 years (±14.3; median, 41 years; range, 2 -79 years); 33.3% of patients were between 40 and 49 years old. Females predominated (71.3%), for a sex ratio of 0.4. Immunological failure was observed in 20.2% of patients (CD4 < 200 cells/µL), and 44.5% of patients had a load of RNA HIV-1 ≥ 1000 copies/mL. The main haematological anomalies were anaemia (28.0%), leukopenia (26.7%), neutropenia (42.1%) and lymphopenia (27.2%). Blood creatinine was abnormal in 61.0% of patients, ALAT in 57.0% and ASAT in 66.9%. Conclusion: The abnormalities observed in this study concerned the haematopoietic system, the liver and the kidneys. As other organs and systems may be affected, periodic multidisciplinary biological and clinical follow-up is necessary for people living with HIV in order to improve their management.

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Some haematological parameters in Human Immunodeficiency Virus (HIV) infected Africans: the Nigerian perspective

Cited by 43 publications

References 0 publications

Profile of Micronutrients, Electrolytes, Haematology and CD4 Count in HIV Infected Subjects on Highly Active Antiretroviral Therapy

Profile of Micronutrients, Electrolytes, Haematology and CD4 Count in HIV Infected Subjects on Highly Active Antiretroviral Therapy

A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS

Biological Profile of HIV-Positive Patients in Bangui, Central African Republic, in 2017

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