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The prevalence of D u phenotype was investigated among rhesus negative women of childbearing age (15-45 years) in Port Harcourt, Nigeria, over a period of 17 months. A total of 1,108 women were randomly sampled, out of which 1,003 (90.5%) were rhesus positive and 105 (9.5%) rhesus negative. Only one (0.95%) of the Rh-negative women was D u positive while 104 (99.05%) were D u negative (true rhesus negatives). The results show that the incidence of D u phenotype in Nigeria may not be uniform -it is high among the Yorubas (7.5%) and rare among the Ijaws and Efik-Ibibios of the south-east. The results also suggest that D u testing may not be indicated in all individuals initially typed as rhesus negative while being strongly indicated only in areas of high prevalence. More studies are required in other parts of Nigeria to provide data that may facilitate the adoption of a comprehensive nationwide policy on appropriate management of rhesus negative women in the country. This will include the D u testing of all rhesus negative mothers in areas of high D u phenotype prevalence before the prophylactic administration of anti-human immunoglobulin (Rhogam

Deficiencies of protein C and free protein S are unlikely to be etiopathogenetic for pre-eclampsia; therefore, therapeutic intervention should focus on other potential pathogenetic pathways.