Some groups of Toll-like receptor gene polymorphisms and their clinical and pathogenetic manifestations in children with bronchial asthma

Suprun, E. N.; Наговицына, Е Б; Kuderova, Natalia; Suprun, S. V.; Лебедько, О А

doi:10.15789/1563-0625-sgo-2049

Cited by 3 publications

(3 citation statements)

References 18 publications

(11 reference statements)

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“…При чрезмерной активации TLRs эндогенными лигандами может наблюдаться гиперактивная воспалительная реакция и, как результат, повреждение клеток и тканей, а это является патогенетическим механизмом различных заболеваний, в том числе БА [7]. Так как в основе БА лежит, в том числе, нарушение распознавания антигенных молекул, исследование роли Toll-рецепторов, генов, которые регулируют действие этих рецепторов, в патогенезе БА сейчас привлекает внимание исследователей [2,4].…”

Section: эни забайкальский медицинский вестник № 1/2024unclassified

“…За последнее время произошли изменения факторов внешней среды, а именно, снижение заболеваемости за счет программ вакцинации, «очищение» продуктов питания, широкое использование антибактериальных лекарственных средств, и поменялось питание -в рационе стали преобладать насыщенные жиры, а потребление ненасыщенных, наоборот, уменьшилось [21]. Предполагается, что в результате вышеперечисленного произошли изменения совокупного генотипа населения, что, в свою очередь, проявляется «недоразвитием» иммунорегуляторных механизмов, нарушением работы адаптивной иммунной системы, преобладанием Th-2 иммунного ответа [2,22]. Как следствие, у генетически предрасположенных лиц развиваются атопия, аллергические заболевания, в том числе БА, что является одним из объяснений увеличения количества случаев БА за последние десятилетия [23].…”

Section: эни забайкальский медицинский вестник № 1/2024unclassified

“…Помимо этого, своевременная диагностика и лечение хронической формы патологии дыхательных путей в младшей возрастной группе детей является особенно важной проблемой. В конце ХХ -начале XXI века исследователи убедительно показали, что Т-хелперы второго типа (Th-2) играют важнейшую роль в развитии аллергической БА, а с их активацией связаны воспаление и гиперреактивность дыхательных путей [2]. Однако сформированное представление о том, что БА -это аллергическое, эозинофильное, Th-2-опосредованное заболевание, обусловленное экспозицией к аллергенам, стало основой упрощенного понимания сложных патогенетических звеньев патологического процесса.…”

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Toll-Like Receptors and Bronchial Asthma: Part 1

Mineeva,

Makarova,

Antonov

2024

jour

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Bronchial asthma is a chronic disease of the respiratory tract, which is formed by the action of endogenous factors and environmental influences. At the same time, T-helpers of the second type play a major role in the development of bronchial asthma, causing hyperreactivity and inflammation of the respiratory tract. However, the data that bronchial asthma in most cases is an allergic, eosinophilic, T-helper-mediated disease of the second type is insufficient to establish complete control over the course of disease. This is probably due to the fact that endogenous factors play an important role in the pathogenesis of asthma, knowledge of which is currently limited. Toll-like receptors are an established element of the development of bronchial asthma. Their insufficient function or, conversely, the launch of an excessive immune response is associated with the initiation of the disease or its exacerbations. Expanding the understanding of Toll-like receptors leads not only to a more detailed understanding of the pathogenesis of bronchial asthma, but also to the application of this knowledge in practice.

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Section: эни забайкальский медицинский вестник № 1/2024unclassified

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Toll-Like Receptors and Bronchial Asthma: Part 1

Mineeva,

Makarova,

Antonov

2024

jour

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Toll-Like Receptors and Bronchial Asthma: Part 2

Mineeva,

Makarova,

Antonov

2024

jour

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For the last decade, the attention of researchers has been attracted by Toll-like receptors that provide recognition of pathogens and trigger an immune response to them. As participants in acute infectious processes, with inadequate stimulation associated with mutation of genes regulating expression of the receptors, they cause the initiation or exacerbation of asthma in predisposed individuals. At the same time, the reduced function of the receptors leads to an insufficient immune response in respiratory infectious diseases, which also leads to an exacerbation of bronchial asthma. In addition, Toll-like receptors are direct elements of the pathogenesis of bronchial asthma, supporting or reducing inflammation. Thus, Toll-like receptors can not only aggravate the course of asthma, but also prevent exacerbations of the disease. Knowledge of the role of these receptors in the pathophysiology of bronchial asthma is necessary to improve diagnostic methods and timely detection of the disease. Using data on the effects realized by the receptors, medicines are being developed that are antagonists or agonists of a Toll-like receptors. The use of medicines acting on receptors in the treatment and prevention of asthma in the future may lead to increased control over the course of the disease.

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The role of Toll-like receptors in the pathogenesis of bronchial asthma

Mineeva,

Makarova

2023

Scientific Bulletin of the Omsk State Medical University

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Bronchial asthma (BA) is a chronic disease of the respiratory tract, which is formed under the action of endogenous factors and environmental influences. It is now believed that type 2 T-helper cells play a major role in the development of bronchial asthma by causing airway hyperresponsiveness and inflammation. However, the evidence that bronchial asthma is mostly an allergic, eosinophilic, type 2 T-helper-mediated disease is insufficient to establish complete control of the course of AD. This is probably due to the fact that endogenous factors play an important role in the pathogenesis of the disease, knowledge of which is currently limited. Consequently, continued study of asthma pathogenesis is an important and relevant direction in medicine. Over the last decade, the attention of researchers has been drawn to Toll-like receptors, which provide recognition of pathogens and trigger an immune response to them. There are conflicting data in the literature on the role of Toll-like receptors in the pathogenesis of AD, but their involvement in the development of the disease is confirmed by numerous studies. As participants of acute infectious processes, under inadequate stimulation associated with mutation of genes regulating receptor expression, they cause initiation or exacerbation of asthma in predisposed individuals. At the same time, reduced receptor function leads to a decrease in the body's defenses, which also leads to exacerbation of AD. In addition, Toll-like receptors are direct elements of the pathogenesis of bronchial asthma, supporting or reducing inflammation. Thus, Toll-like receptors may not only exacerbate the course of AD but also protect against exacerbations. Better knowledge of the role of these receptors in the pathophysiology of AD may lead to improved diagnostic methods, thereby increasing the likelihood of timely detection of the disease. Using data on the effects realized by receptors, drugs are being developed that are antagonists or agonists of a particular Toll-like receptor. The use of drugs acting on receptors in the treatment and prevention of AD may further lead to improved control of the disease course.

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Some groups of Toll-like receptor gene polymorphisms and their clinical and pathogenetic manifestations in children with bronchial asthma

Cited by 3 publications

References 18 publications

Toll-Like Receptors and Bronchial Asthma: Part 1

Toll-Like Receptors and Bronchial Asthma: Part 1

Toll-Like Receptors and Bronchial Asthma: Part 2

The role of Toll-like receptors in the pathogenesis of bronchial asthma

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