Some features of breast cancer and thyroid deficiency.Report of 280 cases

Backwinkel, Klaus D.; Jackson, Arnold S.

doi:10.1002/1097-0142(196409)17:9<1174::aid-cncr2820170913>3.0.co;2-c

Cited by 41 publications

(13 citation statements)

References 6 publications

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“…The remaining 5 reports (15%) were editorials, comments, letters and opinion statement type of publications and, hence, were not amenable to quantitative analysis [37][38][39][40][41] . Taking into account the selection criteria mentioned in the Methods section above, only 13 of the 29 studies (45%) cited in table 1 were evaluable (designated by an asterisk [*] in Table 1) 4,5,11,13-16,18,21,26,27,29,31 .…”

Section: Resultsmentioning

confidence: 99%

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Sarlis¹,

Gourgiotis²,

Pucino³

et al. 2002

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Several authors have suggested a positive association between Hashimoto thyroiditis (HT) and breast cancer (BrCa). Others have refuted these findings; hence, this subject remains controversial. We therefore reviewed the world literature on this subject accumulated over the last 50 years and performed a quantitative research synthesis, a meta-analysis variant. The incidence risk ratios and 95% confidence intervals (CI's) were calculated for each study and the combined relative risk (RR) was estimated. We found 37 relevant studies, of which only 13 were accessible to analysis. A significant association (RR=1.40; CI=1.29-1.53, P<0.022) was found for 6 of the 13 studies pertaining to 1,431 women. However, in the cumulative population of 14,226 women (from all 13 studies), we failed to demonstrate an association between the diagnoses of HT and BrCa (RR=1.07; CI=0.99-1.15; P=0.08). In conclusion, we believe that selection bias or institutional referral bias, in at least some of the "positive" studies, may have led to the spurious recognition of an association between HT and BrCa, especially as both of these conditions are highly prevalent in women between the 4th and 7th decade of life.

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Section: Resultsmentioning

confidence: 99%

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Sarlis¹,

Gourgiotis²,

Pucino³

et al. 2002

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“…Itoh and Maruchi (1975) reported that the patients with Hashimoto's thydoiditis in Japan have about a fivefold greater incidence of breast cancer than other people. Backwinkel and Jackson (1964) …”

Section: Discussionmentioning

confidence: 99%

Pituitary-thyroid function in patients with breast cancer.

Abe

Hirosaki

Kimura

1980

Tohoku J. Exp. Med.

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“…Nine studies failed to meet the inclusion criteria due the absence of a control group [39,40], use of mortality as primary outcome [38] or failure to confirm the benign thyroid diagnosis [25, 32-34, 41, 42]. The remaining six studies were included in the metaanalysis.…”

Section: Hypothyroidismmentioning

confidence: 99%

Benign thyroid disease is associated with breast cancer: a meta-analysis

Hardefeldt

Eslick

Edirimanne

2012

Breast Cancer Res Treat

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The controversial relationship between benign thyroid diseases and breast cancer (BC) has been investigated for over 50 years. Despite extensive population studies, the results as a whole have been inconsistent. The purpose of this study was to collate and analyse available data, calculating a pooled odds ratio (OR) of the risk of BC in patients diagnosed with benign thyroid diseases. Studies were obtained from a database search of MEDLINE, EMBASE, PubMed, Current Contents Connect and Google Scholar with additional cross checking of reference lists. Inclusion criteria required a confirmed diagnosis of a benign thyroid disease, reporting of an OR or data to calculate an OR (and 95% confidence interval, CI) and the use of an internal control group as the comparator. Collated data was assessed for heterogeneity and a pooled OR calculated. 28 studies were included in the meta-analysis. There was significant evidence of an increased risk of BC in patients with autoimmune thyroiditis, evident in a pooled OR 2.92 (95% CI 2.13-4.01). In addition, the results supported an increased risk associated with the presence of anti-thyroid antibodies (OR 2.02, 95% CI 1.63-2.50) and goitre (OR 2.26, 95% CI 1.39-3.69). Subgroup analysis of antibody presence revealed increased risk associated with both anti-TPO (OR 2.64, 95% CI 1.82-3.83) and anti-TG (2.71, 95% CI 1.58-4.69). Quantitative analysis of hypothyroidism and hyperthyroidism was not significant. While these results indicate an association between thyroid auto-immunity and BC, further prospective studies are required to definitively prove causality.

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Some features of breast cancer and thyroid deficiency.Report of 280 cases

Cited by 41 publications

References 6 publications

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Lack of association between Hashimoto thyroiditis and breast cancer: A quantitative research synthesis

Pituitary-thyroid function in patients with breast cancer.

Benign thyroid disease is associated with breast cancer: a meta-analysis

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