Benign thyroid disease is associated with breast cancer: a meta-analysis

Hardefeldt, Prue J.; Eslick, Guy D.; Edirimanne, Senarath

doi:10.1007/s10549-012-2019-3

Cited by 88 publications

(95 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, other studies have demonstrated a higher (8,21,22) or a lower incidence of thyroid disease in BC cases (23). Hashimoto's disease, with or without positive thyroid antibodies (TPO-Abs and Tg-Abs), has been shown to be associated with an increased risk of BC (8,9,(24)(25)(26)(27) and, according to some studies, with a better prognosis and increased disease-free survival in BC cases (16,28). In our study, it seemed that Hashimoto's disease was not associated with BC; however, the small sample size precluded any definitive conclusions.…”

Section: Discussionmentioning

confidence: 99%

Is there an association between thyroid function abnormalities and breast cancer?

Angelousi

Diamanti-Kandarakis

Zapanti

et al. 2017

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objective: The aim of this study was to evaluate the association between thyroid function abnormalities and breast cancer and, in particular, the prognostic markers of breast cancer.. Subjects and methods: Baseline levels of thyrotropin, free triiodothyronine, free thyroxine and thyroid autoantibodies were measured in 97 women with primary breast cancer, 27 women with benign breast disease, and 4 women with atypical ductal hyperplasia. Their baseline levels were compared with those in 48 healthy women with a normal mammography in the last 2 years. Results: There were no significant associations between history of thyroid disease and breast cancer (p = 0.33). The mean baseline levels of triiodothyronine and thyrotropin did not differ significantly between the compared groups. The mean baseline levels of free thyroxine were found to be significantly higher in the breast cancer group, even after adjusting for thyroid replacement therapy. The presence of thyroid antibodies did not differ significantly between the compared groups. In a subgroup analysis, breast cancer cases with thyroid disease and particularly hypothyroidism had a significantly lower incidence of lymph node metastases compared with breast cancer cases without thyroid disease. Conclusions: Our data confirmed the proliferative effect of thyroid hormones on breast cells, which had previously been shown in vitro. Additionally, thyroid disease and particularly hypothyroid function appeared to be associated with a lower incidence of lymph node metastases. Further studies to determine the prognostic role of thyroid hormones in breast cancer are warranted. Arch Endocrinol Metab. 2017;61(1):54-61

show abstract

Section: Discussionmentioning

confidence: 99%

Is there an association between thyroid function abnormalities and breast cancer?

Angelousi

Diamanti-Kandarakis

Zapanti

et al. 2017

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

show abstract

“…On the other hand, Shering et al (18) and Ito and Maruchi (17) observed that Japanese women with Hashimoto's thyroiditis had a higher incidence of mammary cancer than women without thyroid disease. Two recent meta-analyses showed no significant association, except for autoimmune thyroiditis which increased breast cancer risk; however, the heterogeneity of the studies analyzed precludes firm conclusions (7,22).…”

Section: Discussionmentioning

confidence: 95%

Experimental hypothyroidism increases apoptosis in dimethylbenzanthracene-induced mammary tumors

et al. 2013

View full text Add to dashboard Cite

Abstract. Epidemiological and in vitro data have not provided conclusive evidence concerning the involvement of thyroid hormones (THs) on mammary carcinogenesis. We used an in vivo model to assess the relationship between THs, adipose tissue and breast cancer development. Female Sprague-Dawley rats were treated with a dose of 7,12-dimethylbenz(a)anthracene (15 mg/rat) at 55 days of age and were then divided into four experimental groups: hypothyroid rats (HypoT, 0.01% 6-N-propyl-2-thiouracil in drinking water), untreated control (EUT); hyperthyroid rats (HyperT, 0.25 mg/kg/day T 4 s.c.) and vehicle-treated control rats. The latency of tumor appearance and the incidence and progression of tumors were determined. At sacrifice, blood samples were collected for hormone determinations and samples of tumor and mammary glands were obtained for immunohistological studies. HypoT rats had retarded growth and an increase in mammary fat. The latency was longer (p<0.0001), the incidence rate was lower (p<0.05) and tumor growth was slower in HypoT rats compared to EUT and HyperT rats. Mitotic index and PCNA immunostaining were similar in all groups. HypoT rats showed increased apoptosis (p<0.05) as evaluated by the apoptotic index and TUNEL staining. No differences in serum prolactin and progesterone were observed. However, circulating estradiol (E 2 ) was significantly lower in HypoT and HyperT rats. Serum leptin levels were reduced in HypoT rats even though the abdominal fat mass was similar in all groups. To note, the leptin level was higher in HypoT rats that developed mammary tumors than the level in non-tumoral HypoT rats. In conclusion, hypothyroidism altered animal growth, breast morphology, body composition, leptin secretion and serum E 2 enhancing apoptosis and, consequently, retarding mammary carcinogenesis in rats.

show abstract

“…A recent meta-analysis has been written with the purpose of collating and analyzing available data from 28 studies, calculating a pooled odd ratio (OR) of the risk of breast cancer in patients diagnosed with benign thyroid diseases. 11 The study demonstrated significant evidence of an increased risk of breast cancer in patients with autoimmune thyroiditis (OR: 2.92, 95%CI: 2.13-4.01). Besides the biological mechanisms reported above, the presence of the sodium-iodide symporter (NIS) in both breast and thyroid tissue led to the hypothesis that the uptake and oxidation of iodine may play a role in the development of breast cancer.…”

mentioning

confidence: 84%