Some Factors Associated With Absence of Coronary Heart Disease in Persons Aged 65 or Older*

Brown, Roger; Ritzmann, Leonard W.

doi:10.1111/j.1532-5415.1967.tb01133.x

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…Our findings support Doyle's statement that the serum cholesterol concentration has only limited diagnostic and prognostic value in the individual patient (11). Nevertheless, our study also shows that a low level of serum cholesterol is one of the factors associated with the absence of coronary heart disease in the elderly (12).…”

Section: Discussionsupporting

confidence: 48%

Serum Cholesterol Concentration and Atherosclerotic Cardiovascular Disease in the Aged

Vavrik

Priddle

Liu

1974

J American Geriatrics Society

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The subjects of this investigation were 509 residents of a Home for the Aged -195 men and 314 women whose ages ranged from 60 to 90 years. The cross-sectional study included the distribution and prevalence of various serum cholesterol levels in the different old-age groups and the association between serum cholesterol concentration, blood pressure, diabetes, and the prevalence of atherosclerotic cardiovascular and cerebrovascular diseases (such as ischemic heart disease and stroke). No association was found between serum cholesterol concentration and the level of systolic or diastolic blood pressure. Serum cholesterol concentrations above 250 mg/100 ml were more common in diabetic than in non-diabetic females (p < 0.01) but no such relationship was found in the males. A positive correlation was demonstrated between serum cholesterol concentration and the prevalence of atherosclerotic cardiovascular diseases (p < 0.01). In patients with clinically evident coronary and/or cerebral atherosclerosis, the greater prevalence of high serum cholesterol concentrations (above 250 mg/100 ml) was statistically significant in both sexes (p < 0.01).The results of this study support the view that there is a relationship between serum' cholesterol concentration and the prevalence of atherosclerotic cardiovascular diseases even in the older age groups. In the individual patient, however, the serum cholesterol concentration has only limited diagnostic and prognostic value.Hypercholesteremia is one of the so-called major high-risk factors in the development of atherosclerosis. A definitive correlation has been shown between serum cholesterol concentration and the incidence of ischemic heart disease (ISHD) in younger and middle-aged persons (1). However, little has appeared in the medical literature on the subject of blood lipids and atherosclerosis in older people (2-4). Even in the recent publications, disagreement is frequent as to whether or not there is any association between the levels of serum lipids,

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Section: Discussionsupporting

confidence: 48%

Serum Cholesterol Concentration and Atherosclerotic Cardiovascular Disease in the Aged

Vavrik

Priddle

Liu

1974

J American Geriatrics Society

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“…Low-Risk Subjects (N = 137) Figure 3 shows the relationship between serum cholesterol concentration (mg/lOO ml) and age (years), in males of the following groups: 1) at high risk to coronary heart disease; 2) from the 15 (34)]; and individual 17-ketosteroids and reducing steroids by quantitative paper chromatography (35,36).…”

Section: Estimation Of Age By Use Of Lipid and Steroid Variates Inmentioning

confidence: 99%

Urinary Steroids in the Measurement of Aging and of Atherosclerosis†

Marmorston

Griffith

Geller

et al. 1975

J American Geriatrics Society

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Several studies conducted by the authors' group have shown that urinary steroid measurements are a valuable aid in differentiating the normal aging process, the pronounced aging associated with increased risk to coronary heart disease, and the deviations associated with myocardial infarction. Data are presented on 428 men in the age range of 30-70 years. The study design most effective in elucidating aging and disease patterns involves selection of subjects from a wide age range. Data on persons identified as clinically normal can be used to describe physiologic aging. Once this is determined, data on persons with disease can be used to identify abnormalities of aging associated with the clinical conditions studied. This approach offers a potential method for differentiating between aging effects and disease effects. The foregoing findings led to the development of an Index of Aging in males, based on combined serum lipid and urinary steroid values. This Index may be a means of differentiating between normal aging and the deviations seen in atherosclerosis and myocardial infarction. Current studies are directed toward extending these observations.

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“…Studies on factors associated with the absence of coronary disease in the elderly (Brown and Ritzmann, 1967) and the well known familial pattern of longevity suggest that this resistance to atherosclerosis and failure is likely to be genetically determined.…”

Section: Cardiac Murmurs and Pathological Findingsmentioning

confidence: 99%

Pathology of the heart in the tenth decade

Pomerance

1968

J Clin Pathol

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SYNOPSISThe pathology of the heart was studied in 60 patients dying in their tenth decade in a general hospital. The severity of coronary atherosclerosis and the incidence of ischaemic heart disease was lower than in younger geriatric patients. The incidence of minor 'aging' changes was similar to that in younger patients with the exception of mitral valve atheroma where the increase with aging continued into the tenth decade. Marked nodular thickening of the tricuspid valve was seen only in males. Over half the systolic murmurs heard were associated with mitral valve abnormalities and not with aortic valve changes. Multiple car iac pathology was more frequent than in younger patients but its association with failure was much less striking. It is concluded that resistance to the development of coronary atherosclerosis and to failure being precipitated by the multiple minor cardiac abnormalities associated with aging are important factors in attaining extreme longevity.As cardiovascular disease is the main cause of death in adults, the hearts of patients with exceptionally long life spans are of considerable interest. Survival into the tenth decade is still relatively uncommon and few pathological studies have been made on such people. The largest group consists of 40 nonagenarians from a south London geriatric research unit (Howell, 1963; 1964 (Table I). Almost threequarters of these patients had been in normal rhythms: auricular fibrillation was the commonest abnormality (17%) and other abnormalities inincluded multiple extrasystoles and complete heart block. Hypertension appeared relatively uncommon (10%), only one male and five females having readings of 200/100 mm Hg or above. Heart murmurs were heard in 31 % of the males and 44 % of females. These were almost all systolic, of variable characteristics, and no correlation between the site, intensity, and conduction described clinically and the subsequent pathological findings could be 'In receipt of a grant from the British Heart Foundation.

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Some Factors Associated With Absence of Coronary Heart Disease in Persons Aged 65 or Older*

Cited by 7 publications

References 12 publications

Serum Cholesterol Concentration and Atherosclerotic Cardiovascular Disease in the Aged

Serum Cholesterol Concentration and Atherosclerotic Cardiovascular Disease in the Aged

Urinary Steroids in the Measurement of Aging and of Atherosclerosis†

Pathology of the heart in the tenth decade

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