Some Comparative Studies Using 99mTc and 131I in Thyroid Scanning

Górowski, T; Oa, Chomicki

doi:10.1055/s-0038-1624975

Nuklearmedizin

1976

DOI: 10.1055/s-0038-1624975

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Some Comparative Studies Using 99mTc and 131I in Thyroid Scanning

T Górowski¹,

Chomicki Oa²

Abstract: SummaryBy comparing thyroid scans made with 99mTc and 131I in 40 euthyroid goiter patients large discrepancies were found in 20% of all cases. For example, “warm” nodules on 99mTc scans were found to be “cold” on 131I scans, or a “cold” nodule on a 99mTc scan was observed as a “warm” one on a 131I scan. The above discrepancies seem to result from the differences in the metabolism of the two radioisotopes in the thyroid and those in the time which elapsed between the administration of the radioisotope and the e… Show more

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Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as “trapping only” nodule at 99mTcO4 − scintigraphy

Dell'Erba

Gerundini

Caputo

et al. 2003

J Endocrinol Invest

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Rarely may a non-hyperfunctioning thyroid nodule present as "hot" at Technetium-99m pertechnetate (99mTcO4-) and "cold" at radioiodine scintigraphy at late acquisitions. We report the case of a hyperthyroid female patient whose 99mTcO4- scintigraphy showed two "hot" nodules, whereas Iodide-131 (131I-) revealed a lack of indicator uptake by the larger, and intense uptake by the smaller nodule. The patient underwent surgery: histology demonstrated that the larger nodule, mismatched at pertechnetate vs iodine scintigraphy, was a papillary carcinoma. Our suggestion is to perform thyroid scintigraphy with radioiodine in hyperthyroid patients with more than one nodule concentrating pertechnetate, especially when an ultrasonographic pattern possibly suspect for malignancy is present.

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Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as “trapping only” nodule at 99mTcO4 − scintigraphy

Dell'Erba

Gerundini

Caputo

et al. 2003

J Endocrinol Invest

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New Approach for Analysing the Discrepancy of Pretherapeutic Tc-99m and Intra-therapeutic I-131 uptake in Scintigraphies of Thyroid Autonomies using a Parametric 3D Analysis Programs

Zuhayra¹

2017

J Radiol Oncol

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Introduction: Radioiodine therapy is a standard procedure in thyroid autonomy treatment. Discrepancies in the visual comparisons of the scintigraphies prepared for this purpose using Tc-99m-O 4 -and I-131 have been known for years. In this study a new method is used to calculate and perform a quantitative comparison of both uptakes using subtraction analysis and 3D imaging. The results and their causes are discussed together with practice-relevant conclusions for better clinical results. Material and Methods:The new method was used in 38 patients with thyroid autonomies for the subtraction analysis of standardized pretherapeutic and intratherapeutic scintigraphies. The parametric distribution of activity was calculated absolutely and as a percentage and displayed three-dimensionally. These results were compared with the visual assessment of the different scintigraphies by the experts. Inclusion criteria were pretherapeutic and intratherapeutic hyperthyroidism without medication affecting the thyroid. The time difference between acquiring the scintigraphies was 28 days maximum.Results: Activity distribution was visually discrepant in 39.5% of cases. 60.5% displayed comparable uptake. The calculated values showed reversed results after applying the new method. The results using our method show a higher rate of calculated discrepancies compared with visual analysis. Conclusion: Accurate functional imaging of the thyroid is next to further aspects very important inestablishing the diagnosis and deciding about the therapy activity for thyroid treatment. In combination with clinical symptoms and laboratory values, Tc-99m-O 4 -scintigram can be used for an orientated, preliminary assessment of functional disorders of the thyroid. But because of the higher rate of found discrepancies, the solely use of Tc-99m-O 4 -scintigram is not always capable for exact and reliable diagnosis. The known reason for this is most probably due to the different biokinetics of both radiopharmaceuticals, which can be imaged more sensitively with this method. Consequently, a scintigram should be performed in the pretherapeutic radioiodine uptake test. Despite higher costs and radiation exposure, alternatively, pretherapeutic use of other diagnostic iodine isotopes like I-123 or -124 should be discussed, because they could overcome the limitation of the different biokinetics. Following this approach the preliminary assessment using Tc-99m-O 4 -scintigraphy can be precised and double checked to improve diagnostic confi dence and treatment results for a better outcome of the patients.

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Some Comparative Studies Using 99mTc and 131I in Thyroid Scanning

Cited by 2 publications

References 2 publications

Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as “trapping only” nodule at 99mTcO4 − scintigraphy

Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as “trapping only” nodule at 99mTcO4 − scintigraphy

New Approach for Analysing the Discrepancy of Pretherapeutic Tc-99m and Intra-therapeutic I-131 uptake in Scintigraphies of Thyroid Autonomies using a Parametric 3D Analysis Programs

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