Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as “trapping only” nodule at 99mTcO4 − scintigraphy

Dell'Erba, L; Gerundini, Paolo; Caputo, M.; Bagnasco, Marcello

doi:10.1007/bf03345262

Cited by 15 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, some clinical findings are reported as the risk factors for malignancy: Age <20 or >60 years, male sex, a family history of medullary or papillary thyroid cancer or of familial adenomatous polyposis (Gardner's syndrome), a past history of head or neck radiation, rapid tumor growth, irregular outline, fixation to adjacent structures, symptoms of tumor invasion, and metastases such as enlarged regional lymph nodes [2,9,12,45]. On the other hand, young women, an excessive production of T3, and conflicting results between 99m Tc and 123 I scintigram have been reported as unique risk factors of malignancy in a hot nodule [12,51]. In actual practice, however, few patients have these symptoms, and most nodules are nearly asymptomatic, as in our case [9,12].…”

Section: Discussionmentioning

confidence: 99%

Papillary Thyroid Carcinoma without Metastases Manifesting as an Autonomously Functioning Thyroid Nodule

et al. 2005

View full text Add to dashboard Cite

Abstract.A 59-year-old woman with papillary thyroid carcinoma inside of an autonomously functioning thyroid nodule is described in this report. The patient was referred to our clinic because of rapid weight loss and swelling on the left side of the neck. Ultrasonography of the thyroid demonstrated a nonhomogeneous nodule in the lower part of an enlarged left lobe. Both 99m Tc and 123 I thyroid scintigraphic imaging showed a hot area corresponding to the nodule with lower uptake in the remaining thyroid tissue. Histopathological examination of the nodule revealed papillary adenocarcinoma, and the immunohistochemistry proved weak but positive staining for triiodothyronine and thyroxine. Based on these findings, the nodule was diagnosed as a functioning papillary adenocarcinoma. Although thyroid carcinoma manifesting as a hot nodule on the radionuclide isotope scan is an extremely rare occurrence, the current case is clinically important because it suggests that the diagnosis of a hot nodule cannot always rule out thyroid carcinoma in the nodule, and that even a hot nodule requires careful management so that the malignancy is not overlooked.

show abstract

Section: Discussionmentioning

confidence: 99%

Papillary Thyroid Carcinoma without Metastases Manifesting as an Autonomously Functioning Thyroid Nodule

et al. 2005

View full text Add to dashboard Cite

show abstract

“…They may appear hot or warm on 99 Tc SC and cold on late (24 hours) 123 I or 131 I SC. 99,100,108,109 This is known as the "trapping-only phenomenon". Although such nodules carry a risk of malignancy, they are usually benign.…”

Section: Scintigraphy (Sc)mentioning

confidence: 99%

“…Although such nodules carry a risk of malignancy, they are usually benign. [108][109][110][111][112][113][114] Therefore, it is recommended by some authors that patients with hot or warm nodules on 99 Tc SC undergo 123 I SC, 110,115 especially if serum TSH is not suppressed. 109 SC has several limitations.…”

Section: Scintigraphy (Sc)mentioning

confidence: 99%

Thyroid nodules - Stepwise diagnosis and management

Polyzos¹,

Kita²,

Avramidis³

2007

View full text Add to dashboard Cite

thyroid nodules are common in clinical practice. they may be solitary within a "normal" thyroid gland or dominant within a multinodular goiter. the incidence of thyroid nodules has been on the rise in recent decades, mainly due to the wider use of neck imaging. therefore, the incidental finding of a thyroid nodule in an asymptomatic patient is not rare. the differential diagnosis of a thyroid nodule is crucial, as malignancy necessitates surgery, while strict patient follow-up is necessary in the case of benignity. Fine-Needle Aspiration biopsy is considered to be the "gold standard" in the selection of patients for surgery. Ultrasonography (Us) can be used to determine changes in the size of nodules during follow-up or to detect recurrent lesions in patients suspected for thyroid malignancy, although there are no specific Us findings that suggest malignancy. surgery is mandatory in cytologically malignant nodules or in cases suspicious for malignancy. the definite diagnosis and consequent therapy is based on the histological findings after surgery. In this review we present an approach to thyroid nodules in five distinct steps, from the clinical or incidental finding of a nodule to the suggested treatment baselines.

show abstract

“…The SNM guidelines list the advantages and disadvantages of 99m Tc-pertechnetate and 123 I-iodide for thyroid imaging (Table 3) (2). In addition to those items (Table 3), many publications have reported discordant results for thyroid nodules when imaged with these 2 different agents (8)(9)(10)(11). Cold thyroid nodules seen on a 123 I scan sometimes appear to accumulate 99m Tc-pertechnetate.…”

Section: Discussionmentioning

confidence: 99%

A Survey of Thyroid Gland Scintigraphy

Crawford¹,

Guarasci²,

Larson³

2009

Journal of Nuclear Medicine Technology

View full text Add to dashboard Cite

The Society of Nuclear Medicine (SNM) published procedure guidelines for thyroid imaging in 1999. We wished to determine how many clinics performing thyroid imaging follow the guidelines and to what extent. Of particular interest to us was the choice of collimator. Methods: We developed a 10-question survey to obtain information on how hospitals perform thyroid imaging. The questions were designed to cover the procedure recommendations of the SNM guidelines. The survey was sent to 350 hospitals randomly selected from 11 states in the northeastern United States. Results: One hundred sixty-five surveys (47%) were returned. Most of the clinics that responded obtain a history, hyperextend the neck, and obtain anterior and anterior oblique views. Twenty-five percent of the respondents obtain all their images with a parallel-hole collimator. Seventy-five percent use a pinhole collimator or a combination of parallel-hole and pinhole collimators. The number of counts and time used for acquiring the images vary greatly. Less than half the respondents palpate the neck for correlation with the scan. Conclusion:The survey results indicated that many clinics do not follow the recommendations of the SNM guidelines. The major deviations from the guidelines were in the choice of collimator, the number of counts or amount of time used to acquire images, and the lack of neck palpation for correlation with the scan.

show abstract

Association of hyperfunctioning thyroid adenoma with thyroid cancer presenting as “trapping only” nodule at 99mTcO4 − scintigraphy

Cited by 15 publications

References 12 publications

Papillary Thyroid Carcinoma without Metastases Manifesting as an Autonomously Functioning Thyroid Nodule

Papillary Thyroid Carcinoma without Metastases Manifesting as an Autonomously Functioning Thyroid Nodule

Thyroid nodules - Stepwise diagnosis and management

A Survey of Thyroid Gland Scintigraphy

Contact Info

Product

Resources

About