1974
DOI: 10.1016/0006-2952(74)90551-6
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Some aspects of evolutionary pharmacology

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Cited by 21 publications
(11 citation statements)
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“…That diverse expression of muscarinic receptor function is found in lower species such as molluscs, in which acetylcholine both attenuates heart rate and stimulates the central nervous system (3,4), together with the structural similarities in the receptors demonstrated here and previously (1), supports the concept that only one major structural form of the receptor may exist (1). Response diversity found with muscarinic receptors in different tissues may therefore be the result of interactions between the receptor protein and different effector molecules in the plasma membrane.…”
Section: Discussionsupporting
confidence: 55%
See 1 more Smart Citation
“…That diverse expression of muscarinic receptor function is found in lower species such as molluscs, in which acetylcholine both attenuates heart rate and stimulates the central nervous system (3,4), together with the structural similarities in the receptors demonstrated here and previously (1), supports the concept that only one major structural form of the receptor may exist (1). Response diversity found with muscarinic receptors in different tissues may therefore be the result of interactions between the receptor protein and different effector molecules in the plasma membrane.…”
Section: Discussionsupporting
confidence: 55%
“…It appears as though the muscarinic receptor may be highly conserved, perhaps throughout a large part of the evolutionary process. There is evidence to suggest that atropine-sensitive acetylcholine responses, indicative of the presence of muscarinic receptors, exist throughout much of the phylogenetic tree, in molluscs, annelids, and arthropods (3,4), including insects, in which muscarinic receptor-specific radioligand binding has been reported (5-7). a1-Adrenergic receptor monomers are proteins with a molecular mass of 80,000-85,000 daltons (8)(9)(10) with a membrane topology and tryptic digest map similar to those of muscarinic receptors (9,10).…”
mentioning
confidence: 99%
“…1) was the earliest to appear during evolution (MICHAELSON 1974). 1) was the earliest to appear during evolution (MICHAELSON 1974).…”
Section: Acetylcholinementioning
confidence: 95%
“…The sensorium is a subject of particular interest, as the great Russian cholinergiker; Mikhail Michelson (1974) denied as late as in the 1970s that sensorium exhibits cholinergic correlates. Yet, the presence of cholinergic pathways in the retina, olivocochlear bundle, olfactory bulb, pedunculopontine projections, geniculorecipient layers, superior colliculus, and somatosensory, auditory, and visual cortices argues against Michelson's notions, and proven cholinergic correlates were established for audition, balance, vision, and nociception (see Karczmar 2007); cholinergic nociception may involve as well the spinal sites.…”
Section: Functions Eeg Phenomena Emotions and Behaviorsmentioning
confidence: 99%