“…However, there is a lack of concensus as to the exact mechanism of action of the drug. Direct stimulation of dopamine receptors (Papeschi, 1974), blockade of neuronal uptake (Fletcher & Redfern, 1970;Heimans, Rand & Fennessy, 1972;Baldessarini, Lipinski & Chace, 1972), catecholamine release (Scatton, Cheramy, Besson & Glowinski, 1970;Von Voigtlander & Moore, 1971;Stromberg & Svensson, 1971;Farnebo, Fuxe, Goldstein, Hamberger & Ungerstedt, 1971) and increased synthesis (Scatton et al, 1970) have all been suggested to be responsible. We have investigated this problem by examining the effect of amantadine on brain concentrations of catecholamines, on the turnover of these amines in the brain, and on the uptake and release of dopamine from isolated synaptosome preparations.…”