Ultrastructural evidence of amantadine and amphetamine noradrenaline releasing action

Pita, E; Pérez, Nicolas

doi:10.1007/bf01936762

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…A depleting effect of amantadine was also demonstrated on noradrenaline-containing vesicles in the adrenal medulla at doses of 2 -5 mg/kg (Pita and Perez, 1976). In central and peripheral neurons the same effect, an action resembling that of amphetamines, was shown at doses of 50-100mg/kg (Farnebo, 1971 ).…”

Section: Release Of Biogenic Aminesmentioning

confidence: 89%

Possible Use of Amantadine in Depression

Huber¹,

Dietrich²,

Emrich³

1999

Pharmacopsychiatry

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Amantadine, originally used in the treatment and prophylaxis of influenza infection, has also proved beneficial in drug-induced Parkinsonism, Parkinson's disease, traumatic head injury, dementia, multiple sclerosis and cocaine withdrawal. Amantadine appears to act through several pharmacological mechanisms, none of which has been identified as the one chief mode of action. It is a dopaminergic, noradrenergic and serotonergic substance, blocks monoaminoxidase A and NMDA receptors, and seems to raise beta-endorphin/beta-lipotropin levels. However, it is still uncertain which of these actions are relevant in therapeutic doses. One new aspect is the antiviral effect of amantadine on Borna disease virus, which it is suspected may possibly play a role in affective disorders. All of these actions could constitute an antidepressant property, and it is suggested that amantadine might work as an antidepressant not through one, but through several mechanisms thought to be related to antidepressant activity. Effects of amantadine on symptoms of affective disorders have been demonstrated in several trials administering it for varying purposes. Additionally, animal studies as well as clinical trials in humans have hinted at an antidepressant activity of amantadine. We present here an overview of the current data. However, only a limited body of evidence is available, and further studies are needed to investigate the efficacy of amantadine as well as its modes of action in depression.

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Section: Release Of Biogenic Aminesmentioning

confidence: 89%