Somatotype and risk of breast cancer: a case-control study in Uruguay

Ronco, Álvaro L.; Mendoza, Beatriz; Varas, Ximena; Jaumandreu, Sylvia; Stéfani, Eduardo De; Febles, Gustavo; Barboza, Rosana; Gateño, Mery

doi:10.1590/s1415-790x2008000200004

Cited by 21 publications

(17 citation statements)

References 34 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The analyzed Uruguayan sample should be recognized as a population subset with evident overweight and obesity (mean BMI =27.6 kg/m2, >40% fat fraction), corresponding also to a high meso-endomorphic pattern, two facts that were already reported (Ronco et al, 2008;Ronco et al, 2009a). The women belonging to low/mid social strata, although they could display some protective factors based on their usual reproductive pattern (early age for the first live birth, high number of full term pregnancies, long breastfeeding periods) have become a high-risk group based on this fact and the diseases which are related to metabolic syndrome.…”

Section: Discussionmentioning

confidence: 53%

“…We and others have thoroughly studied possible links of nutrition and BC, from the dietary viewpoint (Ronco et al, 1996;1999;2002;2010a,b,c,d;De Stéfani et al, 1997a,b; as well as from an anthropometric one (Ronco et al, 2008;2009) and other epidemiologic ones (Ronco et al, 2007;2009 composition, somatotype), some specific components of the metabolic syndrome in the medical history (diabetes, hypertension, dislypidemias, hyperuricemia) and the risk of BC in Uruguayan women, we decided to carry out the present epidemiologic case-control study, whose preliminary report was recently communicated (Ronco et al, 2010d).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diabetes, Overweight and Risk of Postmenopausal Breast Cancer: A Case-Control Study in Uruguay

Ronco¹,

Stéfani²,

Deneo‐Pellegrini³

et al. 2012

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

Obese postmenopausal women increase their risk of developing breast cancer (BC), in particular if they display an android-type pattern of adiposity, which is also associated to increased risks of diabetes mellitus, hypertension and cardiovascular disease. In order to explore the associations among anthropometry (body mass index, body composition, somatotype), some specific items of medical history (diabetes, hypertension, dislypidemias, hyperuricemia) and the risk of BC in Uruguayan women, a case-control study was carried out between 2004-2009 at our Oncology Unit. 912 women of ages between 23-69 years (367 new BC cases and 545 non hospitalized, age-matched controls with a normal mammography) were interviewed. Twenty body measurements were taken in order to calculate body composition and somatotype. Patients were queried on socio-demographics, reproductive history, family history of cancer, a brief food frequency questionnaire and on personal history of diabetes, dislypidemias, hyperuricemia, hypertension and gallbladder stones. Uni-and multivariate analyses were done, generating odds ratios (ORs) as an expression of relative risks. A personal history of diabetes was positively associated to BC risk (OR=1.64, 95% CI 1.00-2.69), being higher among postmenopausal women (OR=1.92, 95% CI 1.04-3.52). The risks of BC for diabetes in postmenopausal women with overweight combined with dislypidemia (OR=9.33, 95% CI 2.10-41.5) and high fat/muscle ratio (OR=7.81, 95% CI 2.01-30.3) were significantly high. As a conclusion, a personal history of diabetes and overweight was strongly associated to BC. The studied sample had a subset of high-risk of BC featured by postmenopausal overweight and diabetic women, who also had a personal history of hypertension and/or dyslipidemia. The present results could contribute to define new high risk groups and individuals for primary as well as for secondary prevention, since this pattern linked to the metabolic syndrome is usually not considered for BC prevention.

show abstract

Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Diabetes, Overweight and Risk of Postmenopausal Breast Cancer: A Case-Control Study in Uruguay

Ronco¹,

Stéfani²,

Deneo‐Pellegrini³

et al. 2012

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

show abstract

“…Concerning anthropometry, we have recently reported possible roles of somatotype and risk of BC, which were related to a positive association for high endomorphism among premenopausal women but not in postmenopausal ones (Ronco et al, 2008). On the other hand, the studies on body composition reported that fat weight, fat fraction, muscle weight, muscle fraction and the fat/muscle ratio had associations regarding the risk of BC (Ronco et al, 2009).…”

Section: Introductionmentioning

confidence: 95%

Risk Factors for Premenopausal Breast Cancer: A Case-control Study in Uruguay

Ronco¹,

Stéfani²,

Deneo‐Pellegrini³

2012

Asian Pacific Journal of Cancer Prevention

Self Cite

View full text Add to dashboard Cite

In order to thoroughly analyze risk factors of breast cancer (BC) in premenopausal Uruguayan women, a case-control study was carried out at the Pereira Rossell Women's Hospital, Montevideo, where 253 incident BC cases and 497 frequency-matched healthy controls were interviewed on menstrual and reproductive story, were administered a short food frequency questionnaire and undertook a series of body measurements necessary to calculate body composition and somatotype. Odds ratio (OR) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Among the classical risk factors, only the family history of BC in first degree relatives was significantly associated with risk of premenopausal BC (OR=2.20, 95% CI 1.33-3.62). Interestingly, this risk factor was found to be stronger in women of ages >40 (OR=4.05, 95% CI 2.10-7.81), late menarche (OR= 2.39, 95% CI 1.18-4.

show abstract

“…Risk factors were subdivided into four main categories: Lifestyle-related, reproductive, socio economic and environmental risk factors, respectively, a category of history of BC (Chart 2). Several authors have analysed risk factors of all four categories 30,34,37,38,[40][41][42] . Two studies performed in Uruguay for example, included a broad range of different risk factors 41,42 .…”

Section: Identified Risk Factors Of Bcmentioning

confidence: 99%

“…Several authors have analysed risk factors of all four categories 30,34,37,38,[40][41][42] . Two studies performed in Uruguay for example, included a broad range of different risk factors 41,42 . The author's decision to analyse several distinct and unrelated risk factors may have been influenced by the high incidence of BC in Uruguay.…”

Section: Identified Risk Factors Of Bcmentioning

confidence: 99%