Somatotropic‐Testicular Axis: A crosstalk between GH/IGF‐I and gonadal hormones during development, transition, and adult age

Tenuta, Marta; Carlomagno, Francesco; Cangiano, Biagio; Kanakis, George; Pozza, Carlotta; Sbardella, Emilia; Isidori, Andrea M.; Krausz, Csilla; Gianfrilli, Daniele

doi:10.1111/andr.12918

Cited by 26 publications

(12 citation statements)

References 172 publications

(361 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests that the association of female sex with worse depression and anxiety scores is not due to postmenopausal changes. In fact, the interactions between the somatotropic and the gonadal axes are complex, with both a central stimulatory effect and a peripheral liver resistance to GH mediated by estradiol, leading to different hormonal profiles in male and female subjects [23]; also, a different social and psychological impact of the acromegaly-related facial changes could justify this sex gap in anxiety and depression scores.…”

Section: Discussionmentioning

confidence: 99%

Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at establishing the prevalence of depression, to look for clinical and sociodemographic factors associated with it, and to investigate the respective roles (and interactions) of depression and arthropathy in influencing QoL. Methods One hundred and seventy-one acromegalic patients (95 women and 76 men, aged 20–85 years) among those recruited in a cross-sectional Italian multicentric study were investigated. Each patient filled in three validated questionnaires: AcroQoL, WOMAC (measuring articular pain, stiffness and functionality), and AIMS (evaluating articular symptoms and depression). Results A very high (up to 28%) depression rate was detected in acromegalic subjects. Two patients showing pathological AIMS depression scores, committed suicide during the three years observational period. In our population poor psychological status was significantly associated with female sex. Furthermore, a significant strong correlation was found between AIMS depression score and WOMAC score. Both depression and arthropathy-related motor disability turned out to independently contribute with similar strength to the impairment of QoL. Conclusions We report a high prevalence of depression in acromegaly, which is associated with female sex and arthropathy. Both depression and arthropathy strongly and independently contribute to the impaired QoL of patients. Our study shows that assessment and monitoring of psychological status is mandatory in acromegaly, also suggesting an inexpensive tool for this assessment.

show abstract

Section: Discussionmentioning

confidence: 99%

Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…This suggests that the association of female sex with worse depression and anxiety scores is not due to post-menopausal changes. In fact, the interactions between the somatotropic and the gonadal axes are complex, with both a central stimulatory effect and a peripheral liver resistance to GH mediated by estradiol, leading to different hormonal pro les in male and female subjects [23]; also, a different social and psychological impact of the acromegaly-related facial changes could justify this sex gap in anxiety and depression scores.…”

Section: Discussionmentioning

confidence: 99%

Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

Cangiano

Giusti

Premoli

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’ quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we aimed at establishing the prevalence of depression, to look for clinical and sociodemographic factors associated with it, and to investigate the respective roles (and interactions) of depression and arthropathy in influencing QoL. Methods One hundred and seventy-one acromegalic patients (95 women and 76 men, aged 20–85 years) among those recruited in a cross-sectional Italian multicentric study were investigated. Each patient filled in three validated questionnaires: AcroQoL, WOMAC (measuring articular pain, stiffness and functionality), and AIMS (evaluating articular symptoms and depression). Results a very high (up to 28%) depression rate was detected in acromegalic subjects. Two patients showing pathological AIMS depression scores, committed suicide during the three years observational period. In our population poor psychological status was significantly associated with female sex. Furthermore, a significant strong correlation was found between AIMS depression score and WOMAC score. Both depression and arthropathy-related motor disability turned out to independently contribute with similar strength to the impairment of QoL. Conclusions We report a high prevalence of depression in acromegaly, which is associated with female sex and arthropathy. Both depression and arthropathy strongly and independently contribute to the impaired QoL of patients. Our study shows that assessment and monitoring of psychological status is mandatory in acromegaly, also suggesting an inexpensive tool for this assessment.

show abstract

“…Underlying mechanisms that contribute to this liver sexual dimorphism are pituitary-independent and related to the interaction of oestrogens with their receptors. Namely, the induction of suppressor of cytokine signalling (SOCS)-2 and the inhibition of GHR-Janus kinase (JAK)-2-signal transducer and activator of transcription (STAT)-5 signalling pathway in the liver ( 85 , 86 ) reduce IGF-I secretion from hepatocytes ( 87 ).…”

Section: Gh-igf-i Axis and Hypothalamic-pituitary-gonadal Axismentioning

confidence: 99%

GH Deficiency and Replacement Therapy in Hypopituitarism: Insight Into the Relationships With Other Hypothalamic-Pituitary Axes

et al. 2021

View full text Add to dashboard Cite

GH deficiency (GHD) in adult patients is a complex condition, mainly due to organic lesion of hypothalamic-pituitary region and often associated with multiple pituitary hormone deficiencies (MPHD). The relationships between the GH/IGF-I system and other hypothalamic-pituitary axes are complicated and not yet fully clarified. Many reports have shown a bidirectional interplay both at a central and at a peripheral level. Signs and symptoms of other pituitary deficiencies often overlap and confuse with those due to GH deficiency. Furthermore, a condition of untreated GHD may mask concomitant pituitary deficiencies, mainly central hypothyroidism and hypoadrenalism. In this setting, the diagnosis could be delayed and possible only after recombinant human Growth Hormone (rhGH) replacement. Since inappropriate replacement of other pituitary hormones may exacerbate many manifestations of GHD, a correct diagnosis is crucial. This paper will focus on the main studies aimed to clarify the effects of GHD and rhGH replacement on other pituitary axes. Elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH/IGF-I system and other axes, we will focus on the importance of a correct diagnosis to avoid possible pitfalls.

show abstract

Somatotropic‐Testicular Axis: A crosstalk between GH/IGF‐I and gonadal hormones during development, transition, and adult age

Cited by 26 publications

References 172 publications

Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

GH Deficiency and Replacement Therapy in Hypopituitarism: Insight Into the Relationships With Other Hypothalamic-Pituitary Axes

Contact Info

Product

Resources

About