Somatotrophic receptors in hepatic tissue of the developing male pig

Breier, Bernhard H.; Gluckman, P. D.; Ht, Blair; McCutcheon, S. N.

doi:10.1677/joe.0.1230025

Cited by 56 publications

(34 citation statements)

References 26 publications

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“…Plasma IGF-I concentrations increase significantly during the first 3 weeks after birth (Lee et al, 1991 andLouveau et al, 1996). GH receptors increase over the first 10 days of life in liver and IGF-I receptors decrease in the skeletal muscle and liver (Breier et al, 1989;Lee et al, 1993;Louveau et al, 1996;Schnoebelen-Combes et al, 1996). The somatotropic axis appears to be functional and responsive to GH administration in neonatal pigs although the responsiveness is reduced compared with older pigs (Harrell et al, 1999).…”

Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Morise

Louveau

Huërou‐Luron

2008

Animal

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With genetic selection, the increase in litter size has led to higher variation in within-litter birth weights in pigs. This has been associated with a reduction in mean birth weights and a rise in the proportion of piglets weighing less than 1 kg at birth. Low birth weight pigs exhibit lower postnatal growth rates and feed efficiency, which may be explained by an inadequate digestion and/or nutrient use as a consequence of prenatal undernutrition. It is now documented that there is a relationship between birth weight and subsequent pattern of growth and development of tissues and organs. During the neonatal period, the rapid somatic growth is accompanied by tremendous anatomical, physiological and chemical composition changes. The present review focuses primarily on the influence of low birth weight on adipose tissue and the gastrointestinal tract growth and development during the suckling period. The importance of the somatotropic axis, insulin, thyroid hormones, glucocorticoids, epidermal growth factor and leptin in the regulation of these developmental processes is also considered.

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Section: Regulation Of Porcine Neonatal Growth and Development By Hormentioning

confidence: 99%

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Morise

Louveau

Huërou‐Luron

2008

Animal

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“…Normal barrows, however, have GH levels that are 31% lower than immunocastrates (Metz and Claus, 2003) although steroid concentrations are low as in barrows. Thus, the mechanism that maintains GH in immunocastrates at a level typical for intact boars cannot be due to the feedback effect of steroids on GH secretion (Breier et al, 1989). Rather, it may depend on an interaction between GnRH and growth hormone releasing hormone -E-mail: thsekret@uni-hohenheim.de (GRH) either in the hypothalamus or in the pituitary.…”

Section: Introductionmentioning

confidence: 99%

Effects of immunization against GnRH on gonadotropins, the GH-IGF-I-axis and metabolic parameters in barrows

Bauer

Lacorn

Danowski

et al. 2008

Animal

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Surgically castrated male piglets (barrows) reveal an increase in LH and a decrease in GH compared to untreated boars. Boars that were castrated by immunization against gonadotropin releasing hormone (GnRH) have decreased LH but maintain GH. The difference in GH levels between barrows and immunological castrated boars cannot be explained by testicular steroids because they are low in surgical and immunocastrated boars as well. Therefore, differences in GH concentrations might be due to an interaction between GnRH and growth hormone releasing hormone (GRH) in the hypothalamus or the pituitary. This hypothesis was tested with twelve male piglets that had been castrated within 1 week postnatally and fitted with indwelling cephalic vein catheters at 17 weeks of age. They were split into a control group and an immunized group (each n 5 6). Vaccination with Improvac R was performed at 18 and 22 weeks of age. Specific radioimmunoassays were used for hormone determinations (GH, LH, FSH, testosterone and IGF-I). Additionally, metabolic responses were evaluated by measuring analytical parameters that characterize protein synthesis and breakdown, and body fat content. The second vaccination led to a rapid decrease of LH below the limit of detection whereas FSH decreased more slowly, over a period of 5 weeks, from 2.2 to 0.5 ng/ml. This level of FSH, which corresponds to boar-specific concentrations, was maintained thereafter. GH decreased with increasing age but was not influenced by vaccination and remained at a low concentration typical for barrows. Similarly, IGF-I was not altered by vaccination. Consequently, metabolic status was not changed by immunization. It is concluded that the difference in GH levels between surgical and immunocastrated boars is not explained by an interaction between GnRH and GRH.

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“…Essa aparente ausência de resposta pode ser atribuída à falta de receptores hepáticos em leitões jovens (Breier et al, 1989). Esse fato pode explicar a ausência de resultados com relação ao hormônio do crescimento, em função da dieta, principalmente zinco suplementar.…”

Section: Resultsunclassified

Leitões recém-desmamados alimentados com dietas contendo proteína láctea e zinco suplementar

et al. 2010

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RESUMO -Avaliaram-se os efeitos da utilização de proteína láctea ou zinco suplementar na dieta sobre o desempenho, os pesos relativos do intestino delgado e fígado, a morfologia intestinal e as concentrações séricas de IGF-I (fator de crescimento semelhante à insulina), hormônio do crescimento e zinco em leitões. O experimento teve duração de 14 dias e foi realizado com 60 leitões desmamados aos 21 dias de idade (5,43 + 0,46 kg), em delineamento de blocos casualizados, em fatorial 2 × 2, composto de dois níveis de proteína láctea (com e sem, 4%) e dois de zinco (com e sem, 2.250 ppm) na dieta. No período de 1 a 7 dias de experimento, o zinco proporcionou melhor conversão alimentar e, no período de 1 a 14 dias, promoveu maior pesos aos 14 dias e maior ganho de peso. O fornecimento de proteína láctea na dieta piorou a conversão alimentar nas duas fases (de 1 a 7 dias e de 1 a 14 dias de experimento) e resultou em menor profundidade de cripta no jejuno aos 7 dias e maior altura de vilosidade aos 14 dias de experimento. Aos 7 dias de experimento, Houve interação proteína láctea e zinco para a relação altura de vilosidades:profundidade de criptas do jejuno, a qual foi também maior nos animais recebendo proteína láctea. A adição de zinco na dieta reduziu a concentração de IGF-I e o peso relativo do fígado aos 14 dias de experimento, enquanto o uso de proteína láctea aumentou a concentração de IGF-I. A inclusão de proteína láctea melhorou a conversão alimentar, influenciou a morfologia intestinal e aumentou a concentração de IGF-I, mas a suplementação de zinco não foi eficiente para alterar os níveis de hormônio do crescimento no organismo.Palavras-chave: IGF-I, morfologia intestinal, órgãos, produto lácteo, vilosidades Weaned piglets fed diets with milk protein and supplemental zinc ABSTRACT -It was evaluated the effects of using milk protein or supplemental zinc in the diet on performance, relative weights of small intestine and liver, intestine morphology and IGF-I (insulin-like growth factor) serum concentrations, growth hormone and zinc in piglets. The experiment lasted 14 days and it was carried out using 60 piglets weaned at 21 days of age (5.43 + 0.46 kg) in a complete random design, in a 2 × 2 factorial composed of two levels of milk protein (with and without, 4%) and two levels of zinc (with or without, 2,250 ppm) in the diet. In the 1-7 day experiment period, zinc provided better feed conversion and the in the 1-14 day experiment period, it promoted higher body weight at 14 days and higher weight gain. Supply of milk protein in the diet worsened feed conversion in the two phases (from 1 to 7 days and from 1 to 14 days of the experiment) and it resulted in a lower crypts depth in the jejunum and a higher villous height on day 14 of the experiment.On the 7 th day of the experiment, there was an interaction among milk protein and supplemental zinc for villous height:crypts depth relationship, which was also higher for animals fed milk protein. The addition of zinc in the diet reduced insuline-like growth factor...

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Somatotrophic receptors in hepatic tissue of the developing male pig

Cited by 56 publications

References 26 publications

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Effects of immunization against GnRH on gonadotropins, the GH-IGF-I-axis and metabolic parameters in barrows

Leitões recém-desmamados alimentados com dietas contendo proteína láctea e zinco suplementar

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