Somatostatin inhibits VIP‐ and isoproterenol‐stimulated cyclic AMP accumulation in rat prostatic epithelial cells

Carmena, Marı́a J.; Sancho, J.I.; Fernandez-Gonzalez, M.A.; Escudero, Francisco; Prieto, Juan Carlos

doi:10.1016/0014-5793(87)81021-9

Cited by 11 publications

(4 citation statements)

References 14 publications

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“…The presence of these subepithelial nerves in the ampular acini suggests a role for the VIP in the regulation of their secretory activity (Juarranz et al, 2001; Ventura et al, 2002). This agrees with the detection of vipergic receptors in the epithelium of rat prostate (Carmena et al, 1985; Carmena et al, 1986a; Carmena et al, 1986b; Carmena et al, 1988).…”

Section: Discussionsupporting

confidence: 91%

Stereological Quantification of Nerve Fibers Immunoreactive to PGP 9.5, NPY, and VIP in Rat Prostate During Postnatal Development

Rodríguez

Pozuelo

Martı́n³

et al. 2005

Journal of Andrology

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This work was undertaken to study prostate innervation during the postnatal development of rats. It deals with the quantification of nervous fibers throughout all the regions of the rat prostate during the postnatal development using a general marker for nervous tissue, protein gene product 9.5, and 2 neuropeptides (NPY and VIP). Forty male Wistar rats (prepubertals, pubertals, young, and aged adults) were studied for immunohistochemistry of protein gene product (PGP 9.5), neuropeptide Y (NPY), and vasoactive intestinal polypeptide (VIP). They were also evaluated for length density of nerve fibers (L(V) PGP 9.5, L(V) NPY, L(V) VIP). Nerve fibers immunoreactive to the 3 antigens studied were detected in all the groups and in all the prostate zones. Periductal L(V) NPY evidenced a significant increase in the pubertal group, maintained throughout adult life. Periductal L(V) VIP showed a significant increase in young adults. The length densities of VIP and NPY fibers were significantly higher in periductal and ampular locations in comparison with dorsal and ventral sites. It can be concluded that the relative amount of nerve fibers in rat prostate, detected by PGP 9.5, does not change during postnatal development. There were significant changes in NPY and VIP fibers, showing an increase in periurethral ducts at puberty. The abundance of peptidergic innervation around the excretory ducts is related to their contractility. The development of innervation of periurethral ducts is regulated by androgens.

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Section: Discussionsupporting

confidence: 91%

Stereological Quantification of Nerve Fibers Immunoreactive to PGP 9.5, NPY, and VIP in Rat Prostate During Postnatal Development

Rodríguez

Pozuelo

Martı́n³

et al. 2005

Journal of Andrology

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“…The mechanisms by which ArSS1 causes muscle contraction in A. rubens are unknown. One possibility would be that it inhibits the release of a muscle relaxant, as has been reported for SS ( 41 , 42 ). Alternatively, ArSS1 may have a direct excitatory effect on muscle in starfish.…”

Section: Discussionmentioning

confidence: 94%

“…However, the myoexcitatory effect of ArSS1 in A. rubens is interesting because hitherto it has been discovered that SS-type and ASTC-type neuropeptides in other taxa typically act as inhibitory regulators of physiological processes at the cellular level ( 13 , 14 , 23 – 26 ). There are reports of SS causing muscle contraction of guinea pig gastric smooth muscle cells, but investigation of the mechanisms of action indicate that this is a consequence of SS causing inhibition of the release of a muscle relaxant (e.g., vasoactive intestinal peptide) [i.e., SS is causing disinhibition ( 41 , 42 )]. The mechanisms by which ArSS1 causes muscle contraction in A. rubens are unknown.…”

Section: Discussionmentioning

confidence: 99%

Somatostatin-type and allatostatin-C–type neuropeptides are paralogous and have opposing myoregulatory roles in an echinoderm

Zhang

Yáñez-Guerra

Tinoco

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Somatostatin (SS) and allatostatin-C (ASTC) are inhibitory neuropeptides in chordates and protostomes, respectively, which hitherto were identified as orthologs. However, echinoderms have two SS/ASTC-type neuropeptides (SS1 and SS2), and here, our analysis of sequence data indicates that SS1 is an ortholog of ASTC and SS2 is an ortholog of SS. The occurrence of both SS-type and ASTC-type neuropeptides in echinoderms provides a unique context to compare their physiological roles. Investigation of the expression and actions of the ASTC-type neuropeptide ArSS1 in the starfish Asterias rubens revealed that it causes muscle contraction (myoexcitation), contrasting with myoinhibitory effects of the SS-type neuropeptide ArSS2. Our findings suggest that SS-type and ASTC-type neuropeptides are paralogous and originated by gene duplication in a common ancestor of the Bilateria, with only one type being retained in chordates (SS) and protostomes (ASTC) but with both types being retained in echinoderms. Loss of ASTC-type and SS-type neuropeptides in chordates and protostomes, respectively, may have been due to their functional redundancy as inhibitory regulators of physiological processes. Conversely, the retention of both neuropeptide types in echinoderms may be a consequence of the evolution of a myoexcitatory role for ASTC-type neuropeptides mediated by as yet unknown signaling mechanisms.

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“…The precise physiological functions of ␤-adrenergic receptors in the prostate gland remain speculative, but it has been suggested that a tight coupling between androgen receptor and ␤-adrenergic receptor pathways may be a prerequisite for functional differentiation at that level [18]. As expected, ␤-adrenergic agonists stimulate adenylate cyclase activity in this reproductive organ [19,20]. However, the behavior of this crucial step in the ␤-adrenergic signal-transduction system in the diabetic prostate remains unknown.…”

Section: Introductionmentioning

confidence: 89%

G-proteins and β-adrenergic stimulation of adenylate cyclase activity in the diabetic rat prostate

et al. 1997

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Somatostatin inhibits VIP‐ and isoproterenol‐stimulated cyclic AMP accumulation in rat prostatic epithelial cells

Cited by 11 publications

References 14 publications

Stereological Quantification of Nerve Fibers Immunoreactive to PGP 9.5, NPY, and VIP in Rat Prostate During Postnatal Development

Stereological Quantification of Nerve Fibers Immunoreactive to PGP 9.5, NPY, and VIP in Rat Prostate During Postnatal Development

Somatostatin-type and allatostatin-C–type neuropeptides are paralogous and have opposing myoregulatory roles in an echinoderm

G-proteins and β-adrenergic stimulation of adenylate cyclase activity in the diabetic rat prostate

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