G-proteins and β-adrenergic stimulation of adenylate cyclase activity in the diabetic rat prostate

Hormonal Sensitivity of Adenylyl Cyclase in the Myocardium, Brain and Testes of 18-month-old Non-Diabetic and Diabetic Rats

“…As has been said above, in the last few years a close relationship was established between the abnormalities and alterations in hormone-sensitive signaling systems and the pathogenesis of the types 1 and 2 DM and its complications [5][6][7][8][9][10][11][12][13][14][15], but no information is available on the functioning of these systems, AC system in particular, in long-term experimental T2DM. Therefore, our study of the functional state of AC system in rats with very long neonatal DM is the first investigation devoted to hormonal signaling in prolonged T2DM that is associated with aging.…”

“…Earlier we and the other authors showed that the alterations and abnormalities in hormonal signaling systems, hormone-sensitive adenylyl cyclase (AC) signaling system in particular, is one of the main causes of the impairment in the nervous system and peripheral tissues in the types 1 and 2 DM, and the severity of these changes was correlated with the severity and duration of the disease [5][6][7][8][9][10][11][12][13][14][15]. Therefore, the study of the changes in hormonal signaling that occur in the tissues and organs of diabetic animals, even at the early stages of DM, makes it possible to monitor the functioning of the nervous and peripheral systems in DM.…”

Sympathetic modulation of immunity: Relevance to disease

“…Sympathetic activation may also regulate prostate cancer progression via β-AR-mediated mechanisms. In rat prostate cells, β-AR agonists stimulate adenylyl cyclase and raise cAMP levels [448,449], and in human prostate cancer cell lines elevated cAMP production drives their differentiation toward a neuroendocrine phenotype [450,451], an effect reversed by removing the cAMP-generating agents [451]. These findings are important because tumor grade, loss of androgen sensitivity, autocrine and paracrine activity, and poor prognosis all correlate with appearance of this neuroendocrine phenotype in human prostate cancer cells.…”

The effects of experimental diabetes mellitus on the adrenergic functions of the rat uterus

“…Experimental diabetes has been shown to decrease the isoprenalin-stimulated adenylyl cyclase activity of a prostatic membrane preparation from STZ-treated rats [74]. It seems possible that DM decreases the Gprotein activation mediated by β 2 -ARs therefore resulting in an uncoupling of the receptor and its signal transduction mechanism, rather than actually decreasing the β 2 -AR density.…”