Somatostatin and 3-oxy-methyl-D-glucose (3-OMG) uptake in isolated chicken intestinal epithelial cells

Abstract

The direct effect of somatostatin on the absorption of 3-oxymethylglucose in epithelial cells isolated from the small intestine of chicken was studied. The presence of somatostatin in the incubation medium at concentrations of 3.5 X 10(-8) M and 7 X 10(-8) M produced significant dose-dependent increases in the accumulation of sugar in the enterocytes. This effect might be due to an increase in the cell membrane permeability caused by hormone action.

Biology of the Gastrointestinal Tract in Poultry

“…The peptide stimulates the uptake of glucose (3-oxy-methyl-D-glucose) by small intestine enterocytes (Abalde et al, 1984) and inhibits glucagon-stimulated lipolysis in chicken adipose tissue (Di Scala et al, 1985). Somatostatin cells are among the most prominent endocrine cells in the proventriculus in both chickens and ducks (Alison, 1989;1990;Yamanaka et al, 1989).…”