Somatostatin analogue pasireotide (SOM230) inhibits catecholamine secretion in human pheochromocytoma cells

Streit, Laura; Moog, Sophie; Hugel, Sylvain; Rame, Marion; Tanguy, Emeline; Andry, Virginie; Schmid, Herbert; Brunaud, Laurent; Bihain, Florence; Nomine-Criqui, Claire; Goumon, Yannick; Lacomme, Stéphanie; Lomazzi, Sandra; Vix, Michel; Mutter, Didier; Vitale, Nicolas; Ory, Stéphane; Gasman, Stéphane

doi:10.1016/j.canlet.2021.10.009

Cited by 8 publications

(3 citation statements)

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“…18 Some researchers suggested that any change in intracellular calcium level can disturbed the secretion and action of different hormones like catecholamine which can lead in pathogenesis of Hypertension. 19 Intracellular calcium also regulates the renin-angiotensin system, which maintains normal blood pressure, vascular tone, and peripheral resistance. 20,21 Other studies have found that changes in intracellular calcium levels contribute to the pathogenesis of hypertension caused by secondary diseases such as hyperparathyroidism, nephritis, vitamin D deficiency, multiple myeloma, and so on.…”

Section: Discussionmentioning

confidence: 99%

Estimation of Serum Calcium Level in the Patients of Hypertension

Ali¹,

Haque²,

Rauf³

et al. 2022

PJMHS

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Background: Hypertension is one of the leading progressive cause of mortality and morbidity in developed as well as developing countries all over the world. Intracellular and extracellular ions of the body regulate the hemostasis of blood pressure. Objective: To estimate the serum calcium level in the patients of newly diagnosed cases of hypertension with normotensive set of subjects. Methodology: This case comparative study was conducted at the medical OPD of Bilawal Medical College and LUMHS Hospital Hyderabad and Jamshoro. 100 subjects were chosen and divided into two groups: 50 normotensive as a control group and 50 hypertensive as a case study group. Selection of samples was done on the basis of the non-probability technique. A sphygmomanometer was used to measure blood pressure, and a kit method was used to measure serum calcium levels. The statistical analysis of the data was carried out by SPSS version 22 by applying the student t test. Results: The mean age of control group subjects was 44 ± 6 years and control group was 42 ± 7 years. The mean systolic Blood pressure of control group was 110 ± 5 mmHg, while in case study group it was 140 ± 10 mmHg. The mean Diastolic blood pressure of control group was 80 ± 5 mmHg, while in case study group it was 105 ± 5 mmHg. The mean serum calcium level in control group was 9.82 ± 0.68 mg/dl and in case study group it was 8.45 ± 0.47 mg/dl. There was significant (p <0.05) difference of serum calcium level was observed in case study group (hypertensive subjects group). Conclusion: This study concluded that disturbance in intracellular calcium levels can be one of contributory factor in the pathogenesis of essential hypertension. Keywords: Essential Hypertension, Serum Calcium, Intracellular Calcium, Blood Pressure.

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Section: Discussionmentioning

confidence: 99%

Estimation of Serum Calcium Level in the Patients of Hypertension

Ali¹,

Haque²,

Rauf³

et al. 2022

PJMHS

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“…For these reasons, it appears relevant for the clinical management to provide the physician not only the diagnosis of PCCs, already a difficult task, but also information relative to the secretion properties and the histopathological aggressive nature [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Computerized tomography texture analysis of pheochromocytoma: relationship with hormonal and histopathological data

Leo

Vara²,

Paccapelo³

et al. 2022

J Endocrinol Invest

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Objectives Pheochromocytomas are rare tumors which can present with heterogeneous secretion profiles, clinical manifestations, and radiologic appearance. Under a histopathological point of view, they can be characterized as more or less aggressive with the Pheochromocytoma of the Adrenal gland Scaled Score (PASS) and the Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP) score. The aim of this study is to analyze the texture analysis characteristics of pheochromocytoma and identify whether the texture analysis can yield information aiding in the diagnosis and the characterization of those tumors. Methods Radiological, biochemical, and histopathological data regarding 30 consecutive patients with histologically confirmed pheochromocytoma were analyzed. Images obtained in the unenhanced, late arterial, venous, and delayed phases were used for the texture analysis. Results Urinary epinephrine and metanephrine levels showed a significant correlation (R2 = 0.946; R2 = 699) in the multivariate linear model with texture features, as well as Ki-67 (R2 = 0.397), PASS score (R2 = 0.182), GAPP score (R2 = 0.705), and cellularity showed a significant correlation (R2 = 0.389). The cluster analysis based on radiomic features resulted in 2 clusters, with significative differences in terms of systolic and diastolic blood pressure values at the time of diagnosis (p = 0.025), GAPP score (4 vs 6, p = 0.05), histological pattern (1–2, p = 0.039), and comedonecrosis (0% vs 50%, p = 0.013). Conclusion In conclusion, our study provides the proof of concept for the use of texture analysis on contrast-enhanced CT images as a noninvasive, quantitative tool for helping in the characterization of the clinical, biochemical, and histopathological features of pheochromocytoma.

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“…Так, известный аналог соматостатина октреотид взаимодействует с SSTR2 и SSTR5 и очень незначительно -с SSTR3 [17][18][19]. Другой циклогексапептидный аналог соматостатина пасиреотид обладает высокой аффинностью и комплексируется с 4 из 5 известных SSTRs (SSTR1, 2, 3 и 5) [20][21][22][23]. Результаты определения аффинности связывания природного соматостатина (SRIF-14) и его аналогов -октреотида, ланреотида и пасиреотидас 5 разными типами SSTRs человека (SSTR1-5) представлены в табл.…”

Section: Introductionunclassified

Cyphetrylin effect on somatostatin receptors expression in transplantable Ca-755 mice tumor

Киселева

Борисова

Delektorskaya

et al. 2022

Rossijskij bioterapevtičeskij žurnal

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Background. Expression evaluation of somatostatin receptors (SSTRs) in tumor cells is necessary for the reasonable use of therapy directed at such receptors.Aim. The affinity determination of the original analogue of somatostatin cyphetrylin for SSTRs of transplanted mice mammary adenocarcinoma Ca-755.Materials and methods. Cyphetrylin was synthesized in the Chemical Synthesis Laboratory of the Research Institute of Experimental Diagnostics and Therapy of Tumors, N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia. Cyphetrylin in tablet form was administered orally at a therapeutic dose of 10 mg/kg for 7 days to female F1 (C57Bl/6 × DBA/2) tumor-grafted Ca-755 mice. Animals of the control group were not administreted with сyphetrylin. Tumor tissue samples were obtained from animals on the 9th and 14th days after Ca-755 transplantation and sent for immunohistochemical study, which was performed on serial paraffin sections by the immunoperoxidase method using primary antibodies to various types of SSTRs.Results. The high frequency of positive expression of SSTR1, SSTR2, and SSTR5 (in 80, 100 and 100 % of tumor samples, respectively) was shown in tumor samples of the control group animals. As a result of cyphetrylin introduction in tumor samples obtained on the 9th day after Ca-755 inoculation, a change in the tumor receptor status was found towards a decrease in the level of expression of SSTR2 (80 % of samples) and SSTR5 (80 % of samples); SSTR1 expression did not change (80 % of samples). Compared to the controlled, in tumor samples after cyphetrylin administration, obtained on day 14 from Ca-755 transplantation, a decrease in the expression level of SSTR2 (80 % of samples), SSTR1 and SSTR5 (60 % of samples for SSTR each type) was noted, due to cyphetrylin binding to SSTRs of tumor cells. The receptors SSTR3 and SSTR4 did not show a high level of expression in the studied Ca-755 tumor samples.Immunohistochemical staining of Ca-755 cells with antibodies to SSTRs showed a tendency to reduction of antigen-positive cells number from 15–50 % in control to 10–40 % on day 9 after Ca-755 transplantation and 10–30 % on day 14 after Ca-755 transplantation.Conclusion. The data obtained indicates the presence in mice transplanted mammary adenocarcinoma Ca-755 of SSTR1, SSTR2 and SSTR5 high level expression due to the binding to which the direct cyphetrylin antitumor effect is realized.

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Somatostatin analogue pasireotide (SOM230) inhibits catecholamine secretion in human pheochromocytoma cells

Cited by 8 publications

References 70 publications

Estimation of Serum Calcium Level in the Patients of Hypertension

Estimation of Serum Calcium Level in the Patients of Hypertension

Computerized tomography texture analysis of pheochromocytoma: relationship with hormonal and histopathological data

Cyphetrylin effect on somatostatin receptors expression in transplantable Ca-755 mice tumor

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