Over five billion people are active cellular subscribers, spending over a trillion dollars a year on communications. Despite this, hundreds of millions of people are still not connected. Implicit in these networks is a top-down design, with large nationscale telecommunication firms deciding when and where coverage will be available. This is enforced by the large capital investment required to run cellular systems; base stations can cost upwards of US$100,000 and require expensive related core infrastructure. Recent technological innovations have enabled much cheaper cellular equipment; a base station now costs around US$10,000 and requires none of the other related systems.This reduction in cost is enabling new models of cellular telephony. Small organizations are suddenly capable of being service providers. In this work we ask, "How successful would bottom-up cellular networks be?" Essentially we argue for and demonstrate a local cellular network, utilizing existing infrastructure (e.g., power, network, and people) to operate at much lower cost, with less required capital, bringing coverage to areas not traditionally able to support cellular deployments. This network also provides sustainable employment and revenue to local entrepreneurs and services for the local community.We demonstrate the value of this concept by conducting an ongoing six-month long field deployment in rural Papua, Indonesia, in partnership with local NGOs. This network is currently live, with 187 subscribers sustainably providing US$830 per month in revenue (US$368 in profit) for the operator and employment for three different credit sellers in the village. We also show that this network provides a valuable service to the community through usage logs and user interviews.

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Purpose:  To determine the frequency of computer vision syndrome and its associated risk factors among under graduate medical students. Study Design:  Descriptive Cross–sectional study. Place and Duration of Study:  Gujranwala Medical College and Rawalpindi Medical University, Pakistan from 5th August to 28th August, 2020. Methods:  A validated self-designed questionnaire was used for this study. The survey instrument was tailored from a published questionnaire which comprised of questions on demographics, frequency of symptoms of computer vision syndrome, pattern of computer usage and ergonomic practices. Results:  Final analysis was run on 326 under graduate medical students. Females were 228 (69%) and 98 (30%) were males. Age of the participants ranged between 17 to 25 years. Overall frequency of CVS was found to be 98.7%. Twenty nine percent students experienced extra ocular complaints and 71% had ocular symptoms. Symptoms of CVS were more commonly observed among those using desktop/laptop at less than forearm length (p = 0.001). Distance of < 12 inches from mobile phone was found to be associated with eye irritation and neck shoulder pain (p = 0.001). Frequency of break of more than 60 minutes was found to be significantly associated with eye irritation (p = 0.002) and excessive blinking and light sensitivity (p = 0.001). The students not using ergonomically comfortable chair were found to suffer more with  symptoms of CVS as compared to those using ergonomically designed chair (p = 0.049). Conclusion:  Health issues related to excessive use of digital devices has become alarmingly high during COVID-19 pandemic. Symptoms of CVS are significantly associated with distance from digital device and less frequent break intervals. Key Words:  COVID-19, Computer Vision Syndrome, Digital eye syndrome, ergonomics, visual display terminals.

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Abstract-The GSM network is the largest network on Earth, providing vital communications service to billions of people. Yet hundreds of millions of people live outside coverage of existing cellular providers. Recently, researchers have demonstrated a new model of cellular connectivity, community cellular, that has the potential to bring coverage to extremely rural populations. Although the total capital costs for these networks (

Defects in the DNA damage repair pathway contribute to cancer. The major pathway for oxidative DNA damage repair is base excision repair (BER). Although BER pathway genes (OGG1, APEX1 and XRCC1) have been investigated in a number of cancers, our knowledge on the prognostic significance of these genes and their role in head and neck squamous cell carcinoma is limited. Protein levels of OGG1, APEX1 and XRCC1 and a proliferation marker, Ki-67, were examined by immunohistochemical analysis, in a cohort of 50 HNSCC patients. Significant downregulation of OGG1 (p<0.04) and XRCC1 (p<0.05) was observed in poorly differentiated HNSCC compared to mod-well-differentiated cases. Significant upregulation of APEX1 (p<0.05) and Ki-67 (p<0.05) was observed in poorly differentiated HNSCC compared to mod-well-differentiated cases. Significant correlation was observed between XRCC1 and OGG1 (r=0.33, p<0.02). Inverse correlations were observed between OGG1 and Ki-67 (r=-0.377, p<0.005), between APEX1 and XRCC1 (r=-0.435, p<0.002) and between OGG1 and APEX1 (r=-0.34, p<0.02) in HNSCC. To confirm our observations, we examined BER pathway genes and a proliferation marker, Ki-67, expression at the mRNA level on 50 head and neck squamous cell carcinoma (HNSCC) and 50 normal control samples by quantitative real-time polymerase chain reaction. Significant downregulation was observed in case of OGG1 (p<0.04) and XRCC1 (p<0.02), while significant upregulation was observed in case of APEX1 (p<0.01) and Ki-67 (p<0.03) in HNSCC tissue samples compared to controls. Our data suggested that deregulation of base excision repair pathway genes, such as OGG1, APEX1 and XRCC1, combined with overexpression of Ki-67, a marker for excessive proliferation, may contribute to progression of HNSCC in Pakistani population.

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Cytoskeletal rearrangement occurs in variety of cellular processes and involves a wide spectrum of proteins. Gelsolin super family proteins control actin organization by severing and capping filament ends and nucleating actin assembly. Gelsolin is the founding member of this family and plays important role in pathogenesis of human neoplasia.This study aimed to investigate the germline mutations and expressional profile of Gelsolin in human breast cancer tissues. For germ line screening PCR-SSCP technique was used while expression was analyzed through quantitative real time PCR. Different types of mutations were observed in Gelsolin coding regions on exons 4, 10, 11, 14 and 15. These mutations include 3 missense nonsynonymous substitution mutations, 2 deletions, 1 insertion and 1 synonymous substitution mutation. Gelsolin transcript level was found significantly lower in breast tumor tissues compared to control samples (p=0.03). Low level of Gelsolin was found in metastatic patients (p=0.002) and patients who died from breast cancer (P=0.03) compared to disease free patients at final follow up. This study shows that level of Gelsolin is down regulated in breast cancer tissues and is linked with metastasis development and death in patients. It is concluded that genetic changes in coding regions of Gelsolin can potentially contribute to genetic instability. These genetic variations and expressional correlation with patient survival may prove to be of significant importance.