Somatomedin-C as a fetal growth promoting factor and amino acid composition of cord blood in Japanese neonates

Nishijima, Mitsushige

doi:10.1515/jpme.1986.14.3.163

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…Importantly, CD3+CD8+ T lymphocyte count in survivors was significantly diminished with respect to nonsurvivors on day 3. A drop in circulating CD3+CD8+ T cells has been described by other authors [52, 54, 61–63]. …”

Section: T Lymphocytessupporting

confidence: 60%

“…T H17 cells contribute to host defense against extracellular bacteria, such as Staphylococcus aureus and Klebsiella pneumoniae as well as fungi [50, 51]. In humans, T H17 lymphocyte count on day 1 and after 6 days in survivors with severe sepsis was higher than that in nonsurvivors [52]. Salomao et al observed an increased proportion of CD4+ lymphocytes producing IL-17 in patients with sepsis [14].…”

Section: T Lymphocytesmentioning

confidence: 99%

“…These cells can downregulate effector activities mediated by CD4+ T cells, CD8+ T cells, NK cells, and also dendritic cells and B cells [37, 52–57]. Recently, Wu et al found that the circulatory Treg lymphocyte counts on day 1 were higher in surviving patients with severe sepsis than those in nonsurviving ones [35].…”

Section: T Lymphocytesmentioning

confidence: 99%

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Role of Circulating Lymphocytes in Patients with Sepsis

Pablo

Monserrat

Prieto

et al. 2014

BioMed Research International

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Sepsis is a systemic inflammatory response syndrome due to infection. The incidence rate is estimated to be up to 19 million cases worldwide per year and the number of cases is rising. Infection triggers a complex and prolonged host response, in which both the innate and adaptive immune response are involved. The disturbance of immune system cells plays a key role in the induction of abnormal levels of immunoregulatory molecules. Furthermore, the involvement of effector immune system cells also impairs the host response to the infective agents and tissue damage. Recently, postmortem studies of patients who died of sepsis have provided important insights into why septic patients die and showed an extensive depletion of CD4 and CD8 lymphocytes and they found that circulating blood cells showed similar findings. Thus, the knowledge of the characterization of circulating lymphocyte abnormalities is relevant for the understanding of the sepsis pathophysiology. In addition, monitoring the immune response in sepsis, including circulating lymphocyte subsets count, appears to be potential biomarker for predicting the clinical outcome of the patient. This paper analyzes the lymphocyte involvement and dysfunction found in patients with sepsis and new opportunities to prevent sepsis and guide therapeutic intervention have been revealed.

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Section: T Lymphocytessupporting

confidence: 60%

Section: T Lymphocytesmentioning

confidence: 99%

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Role of Circulating Lymphocytes in Patients with Sepsis

Pablo

Monserrat

Prieto

et al. 2014

BioMed Research International

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“…Animal models support findings of reduced neuronal DNA and RNA, as well as reduced mRNA for neuronal and glial structural proteins, reductions in synaptic structures, number, and neurotransmitter peptide production (Bass, Netsky, & Young, 1970; Jones & Dyson, 1981; Wiggins, Fuller, & Enna, 1984). Malnutrition also down-regulated growth factors of the CNS that are critical for normal brain development (Nishijima, 1986). …”

Section: Two Research Domains That Support Dual Exposure Studiesmentioning

confidence: 99%

Research Review: Maternal prenatal distress and poor nutrition – mutually influencing risk factors affecting infant neurocognitive development

Monk

Georgieff

Osterholm³

2012

Child Psychology Psychiatry

219

221

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Background Accumulating data from animal and human studies indicate that the prenatal environment plays a significant role in shaping children’s neurocognitive development. Clinical, epidemiologic, and basic science research suggests that two experiences relatively common in pregnancy — an unhealthy maternal diet and psychosocial distress — significantly affect children’s future neurodevelopment. These prenatal experiences exert their influence in the context of one another and yet, almost uniformly, are studied independently. Scope and Method of Review In this review, we suggest that studying neurocognitive development in children in relation to both prenatal exposures is ecologically most relevant, and methodologically most sound. To support this approach, we selectively review two research topics that demonstrate the need for dual exposure studies, including exemplar findings on (1) the associations between pregnant women’s inadequate maternal intake of key nutrients – protein, fat, iron, zinc, and choline – as well as distress in relation to overlapping effects on children’s neurocognitive development; and (2) cross-talk between the biology of stress and nutrition that can amplify each experience for the mother and fetus,. We also consider obstacles to this kind of study design, such as questions of statistical methods for ‘disentangling’ the exposure effects, and aim to provide some answers. Conclusion Studies that specifically include both exposures in their design can begin to determine the relative and/or synergistic impact of these prenatal experiences on developmental trajectories — and thereby contribute most fully to the understanding of the early origins of health and disease.

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“…Eflects of birth weight and intrauterine growth retardation. In many studies of the human infant, a strong positive correlation has been observed between plasma IGF-I and birth weight (12,16,34). In neonatal pigs, when comparisons are made within a breed, body weight and plasma IGF-I at birth are also positively correlated, with SGA piglets having significantly lower circulating levels of IGF-I than their AGA littermates (17).…”

Section: Study 2: Postnatal Nutritionmentioning

confidence: 99%