Somatic Variation of Red Cell Agglutinogens Due to Hormonal Influence

Scheinberg, S. L.; Reckel, R. P.

doi:10.3382/ps.0400795

Cited by 14 publications

(3 citation statements)

References 13 publications

(11 reference statements)

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“…F1 progenies from the mating of the agglutinable strain (BM-C) to the non-agglutinable strain (WL-M) showed the agglutinability of red cells. From the pattern of the agglutinability of red cells with PHA the "Ph" agglutinogen seems to be identical to the "Hi" agglutinogen reported by SCHEINBERG and RECKEL14, 15,16).…”

Section: Discussionsupporting

confidence: 83%

Developmental appearance of the chicken red cell agglutinogen detected with phytohemagglutinin

Mizutani¹,

Fujio²

1971

Nihon Chikusan Gakkaiho

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It has been known that the extract of certain seeds agglutinates the red cells of various animals including chicken2,3,4,9,11). The best known general term for these extracts is phytohemagglutinin (PHA) though the designation lectins is known, too. In various animals including man some PHA are specific for certain blood group factors and demonstrate their usefulness in practical blood typing. BIRD3) found that the seed extract of Glycine soja agglutinated the pigeon red cells but not the chicken red cells. SCHEINBERG and RECKEL14) reported that the seed extract of Lathyrus cicera or Pisum arvence was capable of agglutinating only the red cells of laying hens but among these laying hens there were those which agglutinated and those which failed to agglutinate. Recently, MILLER10) reported that the extract of peanut agglutinated differentially the red cells of ring neck doves, and divided them into two classes (pea-nut positive and peanut negative). The typing of chicken red cells is now a flourlishing scientific activity in many academies as well as commercial poultry breeder establishments. This development was well reviewed by both BRILES5) and GILMOUR7), who indicated the heredity pattern of many chicken red cell antigens. The production of specific reagents by the isoimmunization in large quantities for the typing of chicken red cells is a serious problem, since it is difficult to standardize the reagents from one laboratory to another. But PHA constitutes one of the source of reagents which could be used to differentiate the red cells of individual chicken. In this paper, the finding that the seed extract of Pisum sativum agglutinates the red cells of laying hen and embryo will be reported. Materials and Methods The extract was obtained as follows; the seeds of Leguminosae were soaked in phosphate buffered saline (PBS) at pH7.2 for 48 hours and were homogenized with equal volume of PBS by a homobrender. The extract was obtained by centrifuging the homogenate at 3,000 was thawed and centrifuged at 10,000rpm for 30min. to use the supernatant. Blood samples were obtained from the wing vein of adult chicken by a syringe containing heparin (1,000 units per ml.) and from the umbical vein of embryo by a capillary pipette coated with heparin. The red cells were washed three times with PBS.

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Section: Discussionsupporting

confidence: 83%

Developmental appearance of the chicken red cell agglutinogen detected with phytohemagglutinin

Mizutani¹,

Fujio²

1971

Nihon Chikusan Gakkaiho

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“…He has confirmed the findings of Scheinberg and Reckel [69] that the lectins of Lathyrus cicera and Pisim arvense react with an antigen present on the erythrocytes of mature hens only and has shown that the lectins of Lens culinaris and other plants also react with this HI antigen. Scheinberg and Reckel [70] have also shown that this antigen can be demonstrated on the erythrocytes of both immature chickens and mature cocks when such animals of the cor rect genotype are inoculated with diethylstilbestrol. Their findings indicate that the HI antigen is detected by agglutination only in the presence of sufficient amounts of oestrogen in the blood.…”

Section: Blood Group Systemsmentioning

confidence: 97%

“…Notable developments in the field since then have included a paper by Briles on additional blood group systems [18], a further review by Gilmour [37] and the widening of interest with studies of polymorphic genetic systems in serum and egg albumin, Lush [47], Ogden and others [57] and Baker and Manwell [4] and the relationship between blood groups and histocompatibility antigens Jaffe and Payne [40,41], Jaffe and McDermid [42], Schierman and Nordskog [70], Craig and McDer mid [27]. As a result of this expansion this article will discuss not only chicken blood group systems, but also biochemical polymorphisms of the blood of chickens and the role of blood group antigens in histocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Immunogenetics of the Chicken

McDermid¹

1964

Vox Sanguinis

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Embryological development of the A₂^cl‐antigen of pigeon erythrocytes

1967

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The "A" antigen of pigeon erythrocytes detectable by Phaseolus Zunatus lectin was given the nomenclature "Aze1" to designate it as the agglutinogen of Columba Zivia which is apparently identical to the A2 of man.This antigen appeared at day 10 in ouo and increased linearly to day 17. (The average incubation time of pigeon embryos was 17.4 days.) At the time of hatching 2% of the expected, parental titer was reached. After another linear increase from one to seven days post-hatching, the titer of the squab bloods exceeded the parental titer, arriving at a maximum of 160% at one month post-hatching. The level then slowly decreased to 110% of the average parental titer at three months post-hatching and remained stable thereafter.The ratio of human cells to pigeon cells involved in mixed agglutination was used to show that high-titer bloods (older eggs) contain an abundance of cells with multiple active sites and a few cells lacking active sites, whereas low-titer bloods (younger eggs) contain mostly inactive cells or cells with proportionately fewer sites.Hemagglutination inhibition tests performed on plasma from eggs and neonatal squabs failed to detect the presence of a soluble Aze' antigen. These results, together with the in ovo development of the antigen and the detection of the antigen in embryonic bone marrow cells, indicate that the agglutinogen may develop in the early stem cells and then be carried over onto the maturing red cells.The time of appearance and embryological development of cellular antigens have received intensive investigation from the immunoembryological and genetic standpoints the past two decades. A fascinating review of the appearance of organ antigens during ontogeny has been presented by Flickinger ('62).The development of various red cell antigens has been widely studied also. Moller and Moller ('62) have shown that mouse erythrocyte isoantigens, detected by isoantibodies in adult mice of a different strain, are first found two to three days after birth and increase sharply to the maximum titer by six to ten days after birth. Okada et al. ('62) found that the H antigen on chick embryo red cells is present by the third day of incubation and strong by the sixth. Other antigens were first detected on the sixth, eleventh, or fourteenth day of incubation. The B and D' antigens of chick embryo erythrocytes are present by at least three days of incubation and are near maximal by the fifth day, whereas the D', D3 and D4 antigens first appear after hatching (Briles et al., '48). Some antigens are embryo-specific J. EXP. ZOOL., 165: 117-126.

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Somatic Variation of Red Cell Agglutinogens Due to Hormonal Influence

Cited by 14 publications

References 13 publications

Developmental appearance of the chicken red cell agglutinogen detected with phytohemagglutinin

Developmental appearance of the chicken red cell agglutinogen detected with phytohemagglutinin

Immunogenetics of the Chicken

Embryological development of the A₂^cl‐antigen of pigeon erythrocytes

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Somatic Variation of Red Cell Agglutinogens Due to Hormonal Influence

Cited by 14 publications

References 13 publications

Developmental appearance of the chicken red cell agglutinogen detected with phytohemagglutinin

Developmental appearance of the chicken red cell agglutinogen detected with phytohemagglutinin

Immunogenetics of the Chicken

Embryological development of the A2cl‐antigen of pigeon erythrocytes

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Embryological development of the A₂^cl‐antigen of pigeon erythrocytes