Somatic genome variations in vascular tissues and peripheral blood leukocytes in patients with atherosclerosis

Слепцов, А. А.; Nazarenko, M. S.; Lebedev, I. N.; Skryabin, N. A.; Frolov, A. V.; Попов, В. А.; Барбараш, О. Л.; Барбараш, Л. С.; Puzyrev, V. P.

doi:10.1134/s1022795414080080

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…One study has reported frequent loss of one allele (hemizygosis) in the CEBPD locus in familiar schizophrenia patients (Lee et al 2010a). Gene copy amplification of CEBPD has been associated with glioblastoma ) and loss of heterozygosity in a region containing the CEBPD gene in one patient with atherosclerosis (Sleptsov et al 2014). Mutational analyses have not been published to detect proprietary gene variation as risk factors to suffer or modify the progression of neurological diseases.…”

Section: Polymorphisms In the Human Cebpb And Cebpd Genesmentioning

confidence: 97%

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

Pulido-Salgado

Vidal-Taboada

Saura

2015

Progress in Neurobiology

141

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Section: Polymorphisms In the Human Cebpb And Cebpd Genesmentioning

confidence: 97%

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

Pulido-Salgado

Vidal-Taboada

Saura

2015

Progress in Neurobiology

141

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“…Frequently, loss of heterozygosity of TUSC3 was found in several diseases. Sleptsov demonstrated the heterozygosity loss of TUSC3 in vascular tissues and peripheral blood leukocytes from patients with atherosclerosis. TUSC3 has already been suggested as an important target of genomic rearrangements in epithelial cancers .…”

Section: Mechanisms For Tusc3 Gene Dysfunctionmentioning

confidence: 99%

TUSC3: a novel tumour suppressor gene and its functional implications

Zhai

Fan

et al. 2017

J Cellular Molecular Medi

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The tumour suppressor candidate 3 (TUSC3) gene is located on chromosome region 8p22 and encodes the 34 kD TUSC3 protein, which is a subunit of the oligosaccharyl transferase responsible for the N‐glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for several years, TUSC3 has only recently been identified as a potential tumour suppressor gene. Based on the structure and function of TUSC3, specific mechanisms in various diseases have been investigated. Several studies have demonstrated that TUSC3 is an Mg2+‐transporter involved in magnesium transport and homeostasis, which is important for learning and memory, embryonic development and testis maturation. Moreover, dysfunction or deletion of TUSC3 exerts its oncological effects as a modulator by inhibiting glycosylation efficiency and consequently inducing endoplasmic reticulum stress and malignant cell transformation. In this study, we summarize the advances in the studies of TUSC3 and comment on the potential roles of TUSC3 in diagnosis and treatment of TUSC3‐related diseases, especially cancer.

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“…Our study revealed that feeding the CR diet triggered an increased accumulation of genes encoding COL6A1 and COL6A2, whereas an increase in protein levels was only observed in the case of COL6A1 in animals from the IN-fed group as compared to the control. Previous findings clearly indicate that COL6A1, in addition to the structural properties, also displays pro-angiogenic action, including endothelial cell proliferation, migration and survival, and its higher expression is associated with increased risk of hypertension and atherosclerosis [ 35 , 36 ]. A more recent study by Chen et al [ 37 ] demonstrated that COL6A1 knockdown suppresses MMP2 expression in vascular smooth muscle cell (VSMC).…”

Section: Discussionmentioning

confidence: 99%

Gene and Protein Accumulation Changes Evoked in Porcine Aorta in Response to Feeding with Two Various Fructan Sources

Marynowska

Herosimczyk

Lepczyński

et al. 2022

Animals

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In this study, two different ITFs sources were incorporated into a cereal-based diet to evaluate possible aortic protein and gene changes in nursery pigs. The animals were fed two different experimental diets from the 10th day of life, supplemented with either 4% of dried chicory root (CR) or with 2% of native inulin (IN). After a 40-day dietary intervention trial, pigs were sacrificed at day 50 and the aortas were harvested. Our data indicate that dietary ITFs have the potential to influence several structural and physiological changes that are reflected both in the mRNA and protein levels in porcine aorta. In contrast to our hypothesis, we could not show any beneficial effects of a CR diet on vascular functions. The direction of changes of several proteins and genes may indicate disrupted ECM turnover (COL6A1 and COL6A2, MMP2, TIMP3, EFEMP1), increased inflammation and lipid accumulation (FFAR2), as well as decreased activity of endothelial nitric oxide synthase (TXNDC5, ORM1). On the other hand, the IN diet may counteract a highly pro-oxidant environment through the endothelin–NO axis (CALR, TCP1, HSP8, PDIA3, RCN2), fibrinolytic activity (ANXA2), anti-atherogenic (CAVIN-1) and anti-calcification (LMNA) properties, thus contributing to the maintenance of vascular homeostasis.

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Somatic genome variations in vascular tissues and peripheral blood leukocytes in patients with atherosclerosis

Cited by 8 publications

References 36 publications

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

TUSC3: a novel tumour suppressor gene and its functional implications

Gene and Protein Accumulation Changes Evoked in Porcine Aorta in Response to Feeding with Two Various Fructan Sources

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