SOMA: Subject‐, object‐, and modality‐adapted precision atlas approach for automatic anatomy recognition and delineation in medical images

Abstract

In the multi-atlas segmentation (MAS) method, a large enough atlas set, which can cover the complete spectrum of the whole population pattern of the target object will benefit the segmentation quality. However, the difficulty in obtaining and generating such a large set of atlases and the computational burden required in the segmentation procedure make this approach impractical. In this paper, we propose a method called SOMA to select subject-, object-, and modality-adapted precision atlases for automatic anatomy recognition in medical images with pathology, following the idea that different regions of the target object in a novel image can be recognized by different atlases with regionally best similarity, so that effective atlases have no need to be globally similar to the target subject and also have no need to be overall similar to the target object. Methods: The SOMA method consists of three main components: atlas building, object recognition, and object delineation. Considering the computational complexity, we utilize an all-to-template strategy to align all images to the same image space belonging to the root image determined by the minimum spanning tree (MST) strategy among a subset of radiologically near-normal images. The object recognition process is composed of two stages: rough recognition and refined recognition. In rough recognition, subimage matching is conducted between the test image and each image of the whole atlas set, and only the atlas corresponding to the best-matched subimage contributes to the recognition map regionally. The frequency of best match for each atlas is recorded by a counter, and the atlases with the highest frequencies are selected as the precision atlases. In refined recognition, only the precision atlases are examined, and the subimage matching is conducted in a nonlocal manner of searching to further increase the accuracy of boundary matching. Delineation is based on a U-net-based deep learning network, where the original gray scale image together with the fuzzy map from refined recognition compose a two-channel input to the network, and the output is a segmentation map of the target object. Results: Experiments are conducted on computed tomography (CT) images with different qualities in two body regions -head and neck (H&N) and thorax, from 298 subjects with nine objects and 241 subjects with six objects, respectively. Most objects achieve a localization error within two voxels after refined recognition, with marked improvement in localization accuracy from rough to refined recognition of 0.6-3 mm in H&N and 0.8-4.9 mm in thorax, and also in delineation accuracy (Dice coefficient) from refined recognition to delineation of 0.01-0.11 in H&N and 0.01-0.18 in thorax. Conclusions:The SOMA method shows high accuracy and robustness in anatomy recognition and delineation. The improvements from rough to refined 7806

Histogram Analysis of Computed Tomography Images to Differentiate Lacrimal Lymphoma and Lacrimal Inflammatory Pseudotumor

“…It can also re ects the microstructures of LGTs and the distribution of internal biology indicators. Due to the advantages of the CT gray-scale histogram, it has been used in the differential diagnosis of different types of tumors and tumor grade [10][11][12].…”