Solvothermal and Ultrasonic Preparation of Two Unique Cluster-Based Lu and Y Coordination Materials: Metal–Organic Framework-Based Ratiometric Fluorescent Biosensor for an Ornidazole and Ronidazole and Sensing Platform for a Biomarker of Amoeba Liver Abscess

Abstract

Through powerful solvothermal and facile ultrasonic synthetic strategies, two unique cluster-based lanthanide Lu and Y nanoporous metal organic frameworks (MOFs) have been successfully prepared, namely, {[Lu 2 (L) ,5-tricarboxylic acid). In addition, both the morphologies and nanosizes of Lu-MOF and Y-MOF materials also have been deliberately tuned by adjustable ultrasonic conditions including irradiation time (40, 60, and 80 min) and power (70 w, 100 w). Currently, it is noted that the abuse of antibiotics such as ornidazole and ronidazole leads to great damage to human health, and therefore the development of highly effective and facile detection methods for ornidazole and ronidazole is quite important. Herein, to improve the fluorescent sensing sensitivity of antibiotics, Eu 3+ and Tb 3+ have been introduced into Lu-MOF (under a solvothermal preparation method) to fabricate a dual-emission hybrid material Eu 3+ /Tb 3+ @Lu-MOF through a postsynthesis strategy, which can be successfully applied as a self-calibrated ratiometric fluorescent sensor for ornidazole and ronidazole with high selectivity and sensitivity (the K sv value for ornidazole is 1.0854 × 10 6 [M −1 ], and the K sv value for ronidazole is 1.0595 × 10 7 [M −1 ]) and low detection limit values (2.85 nM for ornidazole and 26.7 nM for ronidazole). On the other hand, amoeba liver abscess (ALA) will easily lead to irregular fever, night sweats, and other tortured symptoms; C-reactive protein autoantibody (CRP Ab) is the important biomarker for the detection of ALA. Given this, Y-MOF (under the solvothermal preparation method) also has been successfully designed to combine FAM-labeled NH-ssDNA to construct the scarcely reported excellent hybrid FAM-labeled NH-ssDNA/Y-MOF sensing platform for the highly effective discrimination of CRP Ab with excellent sensitivity and selectivity in real samples such as human serum solution.

The Decisive Role of Spin States and Spin Coupling in Dictating Selective O2 Adsorption in Chromium(II) Metal–Organic Frameworks**

“…Owing to their fascinating properties such as structural and functional diversity, tunable pore size, and enormous surface area, metal-organic frameworks (MOFs), have tremendous applications in gas storage, [1][2][3][4] molecular separation, [5][6][7][8][9][10] sensors, [11][12][13][14][15] and catalysis. [16][17][18][19][20][21][22] Though zeolites, covalent organic frameworks, and complex hydrides are available for gas separation applications, [23,24] MOF-based separative systems have attracted wide attention due to their high selectivity as a result of their extensive chemical diversity and porous nature in comparison to other classical adsorbate systems.…”

Regulatable Detection of Antibiotics Based on a Near-IR-Luminescent Tubelike Zn(II)–Yb(III) Nanocluster

“…Over the past few years, fluorescent probes have attracted much attention because of their fast response, high sensitivity, and convenient operation. − Lanthanide-based complexes can display superior luminescence properties (e.g., sharp emission peaks, long lifetimes, and large antenna-generated shifts) in both the visible and near-infrared (NIR) ranges. Recently, some visible-luminescent lanthanide metal–organic frameworks (Ln-MOFs) have been designed for the sensing of antibiotics. − Heterometallic d–4f complexes containing Yb­(III), Nd­(III), Sm­(III), and Er­(III) ions may display interesting NIR emission because their light-absorbing units bearing d-block transition-metal ions, for instance, Zn 2+ , Cd 2+ , Ru 2+ , Cr 2+ , and Pt 2+ , can efficiently sensitize NIR lanthanide emission. High-nuclearity metal nanoclusters are of great interest because of their remarkable chemical properties associated with their well-defined structures. , However, so far there are very few reports on the use of NIR-luminescent high-nuclearity d–4f clusters to detect antibiotics.…”

Ultrasound Irradiation Assisted Synthesis of Luminescent Nano Amide-Functionalized Metal-Organic Frameworks; Application Toward Phenol Derivatives Sensing

“…However, the nano-MOFs with various sizes and promising morphologies have been prepared by using ultrasonic irradiation ( Esrafili et al, 2017 ; Jin et al, 2017 ; X. Z.; Wang et al, 2020 ). Recently, we synthesized luminescent nanostructured MOF through a sonochemical procedure ( Khan and Jhung, 2015 ; Hao et al, 2018 ).…”

“…The ultrasonic method is based on the organization, formation and immediate falling of bubbles in a liquid medium, which leads to the formation of the hot spots up to 5,000 C and a pressure of 500 atm, and progress of the chemical reaction and production of the nanoparticles can be derived, simultaneously. However, the nano-MOFs with various sizes and promising morphologies have been prepared by using ultrasonic irradiation (Esrafili et al, 2017;Jin et al, 2017;Wang et al, 2020). Recently, we synthesized luminescent nanostructured MOF through a sonochemical procedure (Khan and Jhung, 2015;Hao et al, 2018).…”