Solvent induced distortion in a square planar copper(II) complex containing an azo-functionalized Schiff base: Synthesis, crystal structure, in-vitro fungicidal and anti-proliferative, and catecholase activity

Isoniazid-Based Schiff's Bases in Bone Cancer Studies Using Mg-63 Cell Lines

“…Cancer, one of the complex diseases, thrives in a heterogeneous and adaptive environment [1][2][3][4][5][6][7][8][9][10]. Bones are affected as a common consequence in metastatic cancer patients with multiple myeloma, breast, prostate, primary colon, lung, and kidney tumors [11,12].…”

Facile synthesis of novel NNO-tethered copper(ii) complexes: characterization details, theoretical studies, promising enzyme-like activities, and biomolecular interactions

“…S17a†), which were consistent with previously reported copper( ii ) ion EPR spectra. 18 The hyperfine spectra at room temperature were quenched when complex 1 solution was treated with DTBC, and a new single-line sharp spectrum was discovered at g = 2.008, confirming the presence of the semiquinone radical (Fig. S18†).…”

“…14–17 It exclusively catalyses the oxygen-mediated oxidation of o -diphenols (catechols) to their quinones with concomitant four-electron reduction of dioxygen to water in each case. 18–21 Phenoxazinone synthase, 22 which is yet another hexameric copper oxidase, is naturally present in Streptomyces antibioticus bacteria. In the final step of actinomycin D production, the enzyme catalyses o -aminophenol derivatives to the phenoxazinone chromophore via six-electron oxidative cyclization.…”

Synthesis of a new benzoate bridged NNO tethered copper(ii) complex: exploration of its bio, catalytic and anticancer activities

“…In this context, copper-containing metalloenzymes are common in nature and are essential for the physiological activation of oxygen. 11–17 Catechol oxidase 14–17 and phenoxazinone synthase, 22 naturally present in Streptomyces antibioticus bacteria, are two renowned multi-copper oxidases that are involved exclusively in oxygen-mediated oxidation of o -diphenols (catechols) 18–21 and o -aminophenol. As soon as the crystal structure of catecholase 24 and phenoxazinone synthase 22 a came into the picture, it drew the attention of people, especially synthetic inorganic and bio-inorganic chemists, all over the world to design bio-inspired small molecules that could match the structural characteristics of metalloenzymes’ active sites.…”