Solvent-free protocol for amide bond formation via trapping of nascent phosphazenes with carboxylic acids

A facile, rapid, one-pot regio/stereoselective synthesis of 2-iminothiazolidin-4-ones under solvent/scavenger-free conditions

“…In this regard, and in continuation of our recent reports on the solvent-free synthesis of amides [19–20], thioamides [21], cyclic imides [22], thiazolidin-4-ones [23], spirothiazolidin-4-ones [24], 1,2,3-triazoles [25], 1,2,3-triazolylchalcones [26], and 1,2,3-triazolyldihydropyrimidine-2-thiones [27], we herein present a one-pot solvent/scavenger-free synthetic protocol for 2-iminothiazolidin-4-ones. This environmentally benign method avoids toxic organic solvents and acid scavengers, the details of which are presented below.…”

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

“…The synthesis of different phosphazene compounds has been reported [13,[45][46][47][48][49][50][51][52][53] but there are only four articles about synthesis of the phosphazene compounds bearing chalcone groups [10,[54][55][56], there are, however, no studies about synthesis of dioxybiphenyl substituted chalcone-cyclophosphazene compounds. The cyclotriphosphazenes bearing 2,2 0 -dihydroxybiphenyl are much more stable to hydrolysis and thermal decomposition than hexachlorocyclotriphosphazene [1].…”

One‐pot solvent‐free transformation of natural triglycerides to ester and amide derivatives over CaO@KC nanostructured catalysts

“…The reaction time for the conversion of WO to corresponding FADs was optimized by carrying out an amidation reaction for 10,20,30,40,50, and 60 minutes. The FADs yield was found to increase from 41% to 99% as the reaction time increased from 10 to 30 minutes, respectively ( Figure 7A).…”

“…Still, some disadvantages such as low product yields, longer reaction time, high reactant amount, lack of catalyst recyclability, contamination of the product due to catalyst leaching, and the formation of undesirable products in stoichiometric amounts are associated with these methods. As a result, the heterogeneous catalysts which are highly efficient, ecologically correct, recyclable, and environment‐friendly are most demanding for advanced catalytic methods for the solvent‐free aminolysis of triglycerides . Biochar‐based (catalyst 6 wt%, yield 98%, reaction time 2.5 hours), zirconia‐alumina nanocatalyst (catalyst 3 wt%, yield 91.6%, reaction time 4 hours), spongy Ni/Fe carbonate‐fluorapatite (catalyst 9.5 wt%, yield 96%, reaction time 2 hours), sodium‐doped nanohydroxyapatite (catalyst 6 wt%, yield 98%, reaction time 2.5 hours), porous BaSnO 3 (catalyst 6 wt%, 96% yield, reaction time 2 hours), CaO/MCM‐41 nanocatalyst (catalyst 5 wt%, yield 96.8%, reaction time 6 hours), and alkali metal‐doped CaO‐based heterogeneous catalysts were reported for natural triglycerides conversion to fatty acid alkyl derivatives.…”