Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Görgülü, Ahmet Orhan; Koran, Kenan; Özen, Furkan; Tekin, Suat; Sandal, Süleyman

doi:10.1016/j.molstruc.2015.01.033

Cited by 68 publications

(22 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally use at olive leaf extract in pre-diabetes and diabetes can lead to possitive effects on learning and memory. [1][2][3]. The present study was designed to investigate effects of the chalcone-phosphazene compounds on human prostate cancer cell line (PC-3).…”

Section: Pc042 the Effects Of Oral Nicotine Administration Through Gementioning

confidence: 99%

“…In this study, it is analyzed whether if donor and isolation criteria have an impact on the efficiency of the islet cell isolation and to assess the cell viability and functionality. METHODS: Between 2013-2015 donors (20 male and 12 female) pancreas tail sections were studied in our center. Islet cell isolation was performed by modifying the isolation method of Ricordi.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Poster Communications

2015

Acta Physiologica

View full text Add to dashboard Cite

OBJECTIVES: The antitumoral efficieny of CP is directly proportional to its administrated dose. However, high doses have a tendency to result in generalized cytotoxicity. Selenium (Se) is a potent nutritional antioxidant that carries out biological effects by its incorporation into selenoproteins, such as glutathione peroxidase. Therefore we aimed to investigate the possible protective effect of Se on CP-induced hepatotoxicity. METHODS: A total of 42 male Spraque-Dawley rats were divided into 6 groups (n=7) (control, 150 mg/kg CP, 0.5 or 1 mg/kg Se and CP+0.5 and CP+1 mg/kg Se groups). In order to determine the protective effects of Se on liver toxicity, the levels of serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were determined. Also, the liver tissues were analysed histologically. RESULTS: Serum ALT (%145), AST (%226), ALP (%88), and LDH (%73) levels increased in CP administrated rats. In groups where CP and Se were given together ALT, AST, ALP, and LDH levels decreased (p<0.05). Histological analysis of liver tissue showed that tissue damage was significantly lower in CP+Se groups. CONCLUSION: Our results show that Se has antioxidant effects and that it may be useful to eliminate CP related oxidative damage. Hacettepe University, Kastamonu Faculty of Medicine, Internal Diseases Department, Ankara,Turkey AIM: Islet cell transplantation is an alternative treatment method for type I diabetes. Sufficient number and the quality of islet cells increase the success of islet cell transplantation. In this study, it is analyzed whether if donor and isolation criteria have an impact on the efficiency of the islet cell isolation and to assess the cell viability and functionality. METHODS: Between 2013-2015 donors (20 male and 12 female) pancreas tail sections were studied in our center. Islet cell isolation was performed by modifying the isolation method of Ricordi. Success of the isolation was determined by IEQ (islet equivalent number)/gram of digested pancreas rate. Average rate is about 4000. Isolations by 4000 and over were regarded as efficient, below 4000 was regarded as inefficient. p<0.05 was considered statistically significant. RESULTS: Isolations were evaluated with criteria such as; donor age, sex, BMI (body mass index), CIT (cold ischemia time), used pancreas weight, viability and SI (stimulation index). When evaluate all those criteria totally for efficiency, no significant difference detected (p>0.05). A significant negatively relationship was found between viability and donor age at 24th and 48th hours, and also again a significant negatively relationship was found between viability and BMI on 24th hour of culture of isolated islet cell (p<0.05). A negative relationship between CIT and SI, obtained on 24th and 48th hours, and donor age and SI measured only on 48.hour (p<0.05). CONCLUSIONS: As a result, the viability and functionality rates of isolated islet cells are similar according to mentioned efficiency criteria. A relation...

show abstract

Section: Pc042 the Effects Of Oral Nicotine Administration Through Gementioning

confidence: 99%

mentioning

confidence: 99%

Poster Communications

2015

Acta Physiologica

View full text Add to dashboard Cite

show abstract

“…The hexachlorocyclophosphazatrienes (1) reacting with functional substitutive atoms are of special interest [23]- [32]. In this, the diols are seemed to be the most important [13], [27], [33]- [38], in which spiro, ansa, linear, and bridged chain molecules were identified. The previous studies have shown the heat-induced conversion of bridged-chain fluorophosphazine into a spiro form along with the catalyst-induced remodeling of eight-membered ansa derivatives into sixmembered spiro isomers [23], [39], [40].…”

Section: Introductionmentioning

confidence: 99%

NMR and DSC studies on the reactions of pentanedioxy spiro-ansa cyclochlorotriphosphazene and pentanedioxy triple-bridged cylochlorotriphosphazene with monofunctional nucleophiles

Gurbanov

Tuna

Ture

2019

Sakarya University Journal of Science

View full text Add to dashboard Cite

In this study, the reactions of 2-(2-hydroxyethyl) thiophene (2) and benzyl alcohol (3) with pentanedioxycyclochlorotriphosphazene (1) and pentanedioxy triple-bridged cylochlorotriphosphazene (6) were studied. The novel cyclotriphosphazene compounds: two di-substituted spiro-ansa, N3P3[O(CH2)5O]-(C6H7OS)]2 (4) and N3P3[O(CH2)5O-(C6H5CH2O)]2 (5); and two fully substituted triple-bridged, N3P3[O(CH2)5O]3-(C6H7OS)6N3P3 (7) and N3P3[O(CH2)5O]3-(C6H5CH2O)6N3P3 (8) derivatives were formed in THF solvent by using NaH base at ambient conditions. Because of their variety of applications, there is a great deal of interest in the preparation of aromatic macrocyclic derivatives of cyclophosphazenes. The main purpose of these studies is to develop bioactive cyclophosphazene derivatives in the search for new effective drug candidates for the treatment of various diseases, in particular, anticancer and antimicrobials. The synthesized compounds (4, 5, 7, 8) were defined using analytical techniques namely Element analysis, TLC/MS system, and NMR spectroscopy. Thermal stabilities, crystal purity, and recrystallization properties and corresponding enthalpies of synthesized derivatives were analyzed in the course of heating and cooling cycles of DSC.

show abstract

“…In phosphazene chemistry, there are many strudies about adamantane, alkoxy-, amino-, thiol and aryloxy substituted phosphazenes [44][45][46][47][48]. However, there are only five articles on the synthesis and characterization of cyclotriphosphazenes containing chalcone compounds as side groups [6,[49][50][51][52]. Because of the interesting features of chalcone and phosphazene compounds, we designed this study with the aim to resolve this gap in the literature.…”

Section: Introductionmentioning

confidence: 99%

Eu+3-doped chalcone substituted cyclotriphosphazenes: Synthesis, characterizations, thermal and dielectrical properties

Biryan

Demirelli

Koran

et al. 2016

Inorganica Chimica Acta

Self Cite

View full text Add to dashboard Cite

A series of new cyclotriphosphazene derivatives (2a-e) were prepared from the reactions of substituted chalcone compounds (1a-e) containing different organic side groups at para position with cyclotriphosphazene (2) bearing dioxybiphenyl. The structures of 2a-e were approved by microanalysis and spectroscopic techniques (MS, FT-IR, 31 P, 1 H, 13 C, and 13 C-APT NMR). The thermal behaviors of compounds 2a-e were investigated by thermogravimetric analysis (TGA). These compounds were found to be stable up to about 300°C. Dielectric properties of 2a-e were measured against temperature (between 25 and 160°C at 1 kHz) and frequency (range from 100 Hz to 5 kHz at 25°C) using means of an impedance analyzer. Among them dielectric properties of methoxy substituted cyclotriphosphazene 2e were found to be higher than other phosphazenes. The compound 2b, which has the lower dielectric property values than other phosphazenes, was selected to determine the influence of Eu +3-doping on the dielectric properties of phosphazenes and doped with Eu +3 at different mole ratios. At the dielectric properties of Eu +3-doped compound 2b (with increasing molar ratios of Eu +3) was observed an excellent increasing according to Eu +3-undoped phosphazene compounds.

show abstract

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Cited by 68 publications

References 61 publications

Poster Communications

Poster Communications

NMR and DSC studies on the reactions of pentanedioxy spiro-ansa cyclochlorotriphosphazene and pentanedioxy triple-bridged cylochlorotriphosphazene with monofunctional nucleophiles

Eu+3-doped chalcone substituted cyclotriphosphazenes: Synthesis, characterizations, thermal and dielectrical properties

Contact Info

Product

Resources

About