Solvent-free one-pot 1,3-Dipolar cycloaddition reactions of dihydropyran derived nitrone

Abstract

Microwave-induced 1,3-dipolar cycloaddition reactions of dihydropyran derived nitrone with various activated alkenes have been studied in situ and found to afford new isoxazolidine derivatives with moderate selectivity.

Synthesis of Some Novel Class of Regioselective Spiro Isoxazolidine Derivatives via 1,3‐Dipolar Cycloaddition Reaction of N‐Benzyl‐C‐fluoro‐substituted Phenyl Nitrones in Ionic Liquid

“…It has been observed that all the reactions were equally efficient as per as time and yields are concerned in ionic liquid. Synthesis and cycloaddition reactions of formamide, benzaldehyde, and chlorohydrin‐derived nitrones (R = NH 2 ; Ph; –CHCl(CH 2 ) 3 OH) have been already reported from our laboratory .…”

Synthesis of some novel fluoro isoxazolidine and isoxazoline derivatives using N-benzyl fluoro nitrone via cycloaddition reaction in ionic liquid

“…In continuation of our effort to establish green methodologies in nitrone cycloaddition reactions, [14][15][16][17][18] herein, we wish to report the use of ionic liquid as recyclable solvent for 1,3-dipolar cycloaddition reactions of N -benzyl fluro nitrone (having vast synthetic potentials) with active alkenes and electron deficient alkynes to produce fluoro isoxazolidine and isoxazoline derivatives with vast biological activity in a one-pot operation (scheme 1, table 1). Compared to conventional conditions, cycloaddition reactions performed in ionic liquids are much faster and selective.…”

Elimination

“…where R 1 = H, Me, Cl, -(CH) 4 -; R 2 = Me, Bn, Ph Chakraborty et al (2012). studied microwave induced 1,3-dipolar cycloaddition reactions of dihydropyran derived nitrone with various activated alkenes.…”