1,3-Dipolar cycloaddition reactions of α-chloro and simple nitrones have been studied with novel α-N-methyl/phenyl furan derivatives as new dipolarophiles. The reactions are found to be highly regioselective to afford single 5-spiro isoxazolidines with high yield in a short reaction time.
Novel isoxazolidines are synthesized by 1,3-dipolar cycloaddition of α-chloro nitrone (I) to dipolarophiles like maleimides (II) or alkene derivatives (V). The reactions proceed both regio-and stereoselectively. -(CHAKRABORTY*, B.; SHARMA, P. K.; CHHETRI, M. S.; J. Heterocycl. Chem. 49 (2012) 5, 1260-1265, http://dx.
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