Solvent-Free Heterocyclic Synthesis

Abstract

Clarissa P. Frizzo was born in Ivora ´, Rio Grande do Sul state, Brazil, in 1983. She received her undergraduate degree in Pharmacy from the Federal University of Santa Maria in 2005, and in 2007 she obtained her M.Sc. degree from the Federal University of Santa Maria, under the supervision of Professor Marcos A. P. Martins, working with the use of ionic liquids in the synthesis of heterocycles. She started her Ph.D. studies under the supervision of Professor Marcos A. P. Martins, and currently she is focusing on her Sandwich Ph.D. in the Universidade Nacional de Educacio ´n a Distancia in Spain, under the guidance of Professor Rosa M. Claramunt Vallespı ´, where she is studying the supramolecular structure of heterocycles. Dayse das Neves Moreira was born in Canguc ¸u, Rio Grande do Sul state, Brazil, in 1984. She received her undergraduate degree in Chemistry from the Federal University of Pelotas, RS, in 2006, and in 2008 she received her M.S. degree, from the Federal University of Santa Maria, RS, Brazil, working under the direction of Professor Marcos A. P. Martins, working with the use of ionic liquids in the synthesis of heterocycles. Currently, she is a Ph.D. student with Professor Marcos A. P. Martins in the Department of Chemistry of the Federal University of Santa Maria. Her major research interest is to develop new methodologies to synthesize heterocyclic compounds. Lilian Buriol was born in Santa Izabel do Oeste, Parana ´(PR) state, Brazil, in 1984. She received her undergraduate degree in Chemistry from the State University of Centro-Oeste (PR). In 2008, she completed her M.S. degree at the same university under the supervision of Professor Yohandra R. Torres, working with oil and ethanol extracts of propolis. After that, she started her Ph.D. studies in the Department of Chemistry of the Federal University of Santa Maria under the supervision of Professor Marcos A. P. Martins. Her research interest is to develop new methodologies to synthesize heterocyclic compounds along the lines of green chemistry.

Iodine-catalyzed Transformation of Aryl-substituted Alcohols Under Solvent-free and Highly Concentrated Reaction Conditions

“…[1][2][3] Transformations of neat reactants under solvent-free reaction conditions (SFRC) are one of the best solutions in this regard. [4][5][6][7] In the solid/solid system, a remarkable reaction rate enhancement was observed just by introducing small amounts of solvent vapor into the reaction mixture. 8 Moreover, the course of the reaction can be dramatically influenced under highly concentrated reaction conditions (HCRC).…”

Evaluation of In Vitro Anti-Inflammatory Activity for Novel Imine Derivatives from Acetylcoumarin by Catalyst-Free Green Solvent

“…Coumarin a bicyclic ring characterized under benzo-alfa-pyrones which are abundantly found in nature. The structure of coumarin posses a wide pharmacological application which mainly found in anti-coagulant RESEARCH ARTICLE (warfarin), treating high protein edema in combination with troxerutin, immunomodlater in chronic infection, anti-cancer, antimalarial, antimicrobial, antibacterial, antifungal, antineurodegenerative, anti-oxidative, antiviral, antiparasitic, anti-inflammatory analgesic, antidiabetic, anti-depressive so on [5][6][7] . Schiff's base are also called imine derivatives which are formed by nucleophilic attack of aryl amine on electrophilic group of aldehyde or ketone in liberation of water called azomethine [8][9][10] .…”

The effect of pressurized carbon dioxide on the cyclocondensation reaction between 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones and hydrazines

“…17 We have used β-alkoxyvinyl trihalomethyl ketones (enones) to build five-, six-, and sevenmembered trihalomethylated heterocyclic compounds. [18][19][20][21] Also, our research group is continuously interested in a more environmentally benign synthesis, demonstrated by our recent papers that focus on solvent-free synthesis 22 and the use of ionic liquids as reaction media, 23 something that is associated with efficient techniques such as microwave 20,21 and ultrasound irradiation. 24 Due to our sustained interest in the study of heterocyclic synthesis and the lack of cyclocondensation reactions under pressurized CO 2 in the literature, herein, we wish to report a mild and efficient method for the preparation of NH-and phenyl-pyrazoles under pressurized CO 2 conditions.…”