Solvent Evaporation Techniques as Promising Advancement in Microencapsulation

Hwisa, Nagiat T.; Katakam, Prakash; Chandu, Babau Rao; Adiki, Shanta Kumari

doi:10.14259/bmc.v1i1.29

Cited by 32 publications

(22 citation statements)

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“…This technique depends on dissolving the lipid and the drug in a partially water miscible organic solvent (e.g., benzyl alcohol, butyl lactate, ethyl acetate, isopropyl acetate and methyl acetate), then the organic solvent is emulsified using an emulsifying agent dissolved in an aqueous phase under agitation. Once emulsion is formed, SLNs are obtained by evaporation of the solvent under low pressure [51].…”

Section: Solvent Emulsification Diffusion Techniquementioning

confidence: 99%

Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery

et al. 2020

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Recently, the occurrence of cancer has significantly increased; it represents the second-most frequent cause of death after cardiovascular diseases. Many dietary antioxidants have shown large impact as effective agents for cancer prevention by reducing oxidative stress, which has been a part in the development of many diseases, including cancer. One of the obstacles in the delivery of antioxidant therapies into the required domain lies in the inadequate delivery of these agents to their intended site of action. Using nanotechnology in delivery of antioxidants leads to increased therapeutic index and higher drug concentration in tumor tissues, thus enhancing anticancer treatment. In this review, we discuss the role of different antioxidants in cancer therapy and their improved therapeutic effect through their formulation using nanotechnology.

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Section: Solvent Emulsification Diffusion Techniquementioning

confidence: 99%

Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery

et al. 2020

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“…By comparing the different types of nanoparticles, nanoparticles prepared by microfluidic technique are showing smaller size and more homogenous distribution and low variation in size as shown in figure (9,11,13). On the other hand, nanoparticles prepared by double emulsion technique are showing slightly bigger particles and more variation in size as shown in figure (8,10,12) comparing to those prepared by microfluidic technique.…”

Section: Morphological Analysis and Imagingmentioning

confidence: 90%

“…The double emulsion consists of many steps in the preparation which consumes a lot of time. Solvent evaporation was applied next to remove the acetonitrile which is a toxic volatile organic solvent by stirring the emulsion for 24 hours at atmospheric temperature or lower which is also a time-consuming method [10] .…”

Section: Methods Of Preparationmentioning

confidence: 99%

Formulation and Optimization of Biodegradable Insulin Loaded Nanoparticles

Eid¹,

Uddin²,

Girgis³

2019

IJPHC

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This research aims to provide the diabetic patients with more adequate treatment by designing controlled release insulin loaded nanoparticles prepared by biodegradable polymers. Factors to be studied in this research are the effect of the preparation methods using two different preparation techniques microfluidic / salting out technique which is a new and promising technique and a conventional technique which is double emulsion /solvent evaporation technique. The characterization of the nanoparticles was performed in the terms of size, zeta potential, morphological analysis, IR spectrophotometry, thermal analysis, loading and in vitro release of the nanoparticles. All the formulations are showing nanoparticles in the range from 300 to 400 nm with a negative zeta potential between-10 and-20 mV. Furthermore, all the nanoparticles are showing smooth spherical shape with chemical and thermal compatibility between the ingredients with encapsulation efficiency that ranges from 42 % to 52 % in all formulations.

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“…This manuscript presents a different approach in which INH was formulated as gastric-resistant sustained-release microspheres with polymers traditionally used for enteric coating, viz., Eudragit ® L100 (Rohm Pharma GmbH, Darmstadt, Germany) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS); and RIF was formulated as microporous floating sustained-release microspheres. In this study, non-aqueous emulsions of acetone (dispersed phase) and liquid paraffin (continuous phase or dispersion medium) were used as these solvents reduce partitioning of the highly water-soluble INH from the microspheres that are formed [21][22][23]. Acetone was selected as the dispersed phase as it is immiscible with liquid paraffin [21,24].…”

Section: Manufacture and Dissolution Testing Of Gastric Resistant Susmentioning

confidence: 99%

Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media

Mwila

Walker

2020

Pharmaceutics

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The degradation of rifampicin (RIF) in an acidic medium to form 3-formyl rifamycin SV, a poorly absorbed compound, is accelerated in the presence of isoniazid, contributing to the poor bioavailability of rifampicin. This manuscript presents a novel approach in which isoniazid is formulated into gastric-resistant sustained-release microspheres and RIF into microporous floating sustained-release microspheres to reduce the potential for interaction between RIF and isoniazid (INH) in an acidic environment. Hydroxypropyl methylcellulose acetate succinate and Eudragit® L100 polymers were used for the manufacture of isoniazid-loaded gastric-resistant sustained-release microspheres using an o/o solvent emulsification evaporation approach. Microporous floating sustained-release microspheres for the delivery of rifampicin in the stomach were manufactured using emulsification and a diffusion/evaporation process. The design of experiments was used to evaluate the impact of input variables on predefined responses or quality attributes of the microspheres. The percent degradation of rifampicin following 12 h dissolution testing in 0.1 M HCl pH 1.2 in the presence of isoniazid gastric-resistant sustained-release microspheres was only 4.44%. These results indicate that the degradation of rifampicin in the presence of isoniazid in acidic media can be reduced by encapsulation of both active pharmaceutical ingredients to ensure release in different segments of the gastrointestinal tract, potentially improving the bioavailability of rifampicin.

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Solvent Evaporation Techniques as Promising Advancement in Microencapsulation

Cited by 32 publications

References 0 publications

Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery

Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery

Formulation and Optimization of Biodegradable Insulin Loaded Nanoparticles

Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media

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