Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery

Ammar, H. O.; Shamma, Rehab Nabil; Elbatanony, Rasha S.; Khater, Basma

doi:10.3390/scipharm88010005

Cited by 11 publications

(12 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidants might prevent cancers than curing them [47,108] Available in a wide variety of fruits and vegetables Difficulty in delivery to tumor mass or internal organs [109,110] Short-lived and ultra-fast acting oxidizing biomolecules Acts on DNA causing mutations and increasing cancer [111][112][113] Prooxidants Increase oxidative stress hindering cancer growth Damage healthy tissues, especially the internal organs [23,114] Synergistic action with many anti-cancer drugs Increase cytotoxicity during radiotherapy [115,116] In general, the mode of action of anti-cancer agents involves increasing the oxidative stress leading to the interference of DNA replication and proliferation of the neoplastic cells. However, incorporation of antioxidants may reduce the efficacy of the anti-cancer therapy by interfering with the production of free radicals.…”

Section: Antioxidants Antagonize Excess Free Radicals In Healthy Cellsmentioning

confidence: 99%

Redox Potential of Antioxidants in Cancer Progression and Prevention

George

Abrahamse

2020

Antioxidants

View full text Add to dashboard Cite

The benevolent and detrimental effects of antioxidants are much debated in clinical trials and cancer research. Several antioxidant enzymes and molecules are overexpressed in oxidative stress conditions that can damage cellular proteins, lipids, and DNA. Natural antioxidants remove excess free radical intermediates by reducing hydrogen donors or quenching singlet oxygen and delaying oxidative reactions in actively growing cancer cells. These reducing agents have the potential to hinder cancer progression only when administered at the right proportions along with chemo-/radiotherapies. Antioxidants and enzymes affect signal transduction and energy metabolism pathways for the maintenance of cellular redox status. A decline in antioxidant capacity arising from genetic mutations may increase the mitochondrial flux of free radicals resulting in misfiring of cellular signalling pathways. Often, a metabolic reprogramming arising from these mutations in metabolic enzymes leads to the overproduction of so called ’oncometabolites’ in a state of ‘pseudohypoxia’. This can inactivate several of the intracellular molecules involved in epigenetic and redox regulations, thereby increasing oxidative stress giving rise to growth advantages for cancerous cells. Undeniably, these are cell-type and Reactive Oxygen Species (ROS) specific, which is manifested as changes in the enzyme activation, differences in gene expression, cellular functions as well as cell death mechanisms. Photodynamic therapy (PDT) using light-activated photosensitizing molecules that can regulate cellular redox balance in accordance with the changes in endogenous ROS production is a solution for many of these challenges in cancer therapy.

show abstract

Section: Antioxidants Antagonize Excess Free Radicals In Healthy Cellsmentioning

confidence: 99%

Redox Potential of Antioxidants in Cancer Progression and Prevention

George

Abrahamse

2020

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the cellular antioxidant defence system can help to regulate oxidative stress by reducing excess ROS and promoting DNA repair [ 28 ]. However, dysregulation within these defence systems can result in resistance to anti-cancer therapies [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of MicroRNA-31 on Oxidative Stress and Radiosensitivity in Pancreatic Ductal Adenocarcinoma

McGrath

Kane

Maher

2022

Cells

View full text Add to dashboard Cite

Radioresistance remains a significant challenge in treating pancreatic ductal adenocarcinoma (PDAC), contributing to the poor survival rates of this cancer. MicroRNAs (miRs) are small non-coding RNA molecules that may play an essential role in regulating radioresistance by altering the levels of oxidative stress. In this study, we investigated the role and potential mechanisms linking miR-31 to PDAC radioresistance. A pCMV-miR vector containing a miR-31 mimic was stably expressed into a miR-31-deficient PDAC cell line, BxPC-3. Additionally, a pmiRZip lentivector suppressing miR-31 was stably expressed in a miR-31 abundant PDAC cell line, Panc-1. Clonogenic assays were conducted to explore the role of miR-31 manipulation on radiosensitivity. Fluorometric ROS assays were performed to quantify ROS levels. The expression of potential miR-31 targets was measured by Western blot analysis. It was found that the manipulation of miR-31 altered the radiosensitivity in PDAC cells by regulating oxidative stress. Using online bioinformatics tools, we identified the 3′UTR of GPx8 as a predicted target of miR-31. Our study demonstrates, for the first time, that manipulating miR-31 alters GPx8 expression, regulating ROS detoxification and promoting either a radioresistant or radiosensitive phenotype. MiR-31 may represent a promising therapeutic target for altering radiosensitivity in PDAC cells.

show abstract

“…Ongoing tests demonstrated that certain conditions should be met before involving antioxidants in chemotherapy. Moreover, they do not hinder but improve the cytotoxic effect of chemotherapy while protecting the typical tissue which subsequently increases the patients' survival and therapeutic response [55].…”

Section: Roles Of Dietary Antioxidants In Cancer Therapymentioning

confidence: 99%

The Two Sides of Dietary Antioxidants in Cancer Therapy

Akanji¹,

Rotimi²,

Lawrence³

et al. 2021

Antioxidants - Benefits, Sources, Mechanisms of Action

View full text Add to dashboard Cite

Cancer is a major cause of mortality around the world, representing about 13% of deaths on the planet. Among the available cancer treatments, chemotherapy is most frequently utilized compared to other treatments such as surgery and radiotherapy. Many dietary antioxidants have proven to effectively prevent oxidative stress, which has been noted in many disease pathogeneses, including cancer. However, during chemotherapy or radiotherapy treatment of cancer patients, antioxidants are used as an adjuvant treatment. The use of a proof-based technique is advised in determining the supplements most suited to cancer patients. Though there are numerous opinions about the dangers and advantages of antioxidants, it is reasonable to conclude that side effects caused by antioxidants, for now, remain unclear for patients during cancer treatment, aside from smokers during radiotherapy. In this report, details of the effectiveness of antioxidants on cancer treatment aiding in the reduction of cancer therapy side effects are discussed.

show abstract

Antioxidants in Cancer Therapy: Recent Trends in Application of Nanotechnology for Enhanced Delivery

Cited by 11 publications

References 93 publications

Redox Potential of Antioxidants in Cancer Progression and Prevention

Redox Potential of Antioxidants in Cancer Progression and Prevention

The Influence of MicroRNA-31 on Oxidative Stress and Radiosensitivity in Pancreatic Ductal Adenocarcinoma

The Two Sides of Dietary Antioxidants in Cancer Therapy

Contact Info

Product

Resources

About