Solvent crystallization of palm based dihydroxystearic acid with isopropyl alcohol: Effects of solvent quantity and concentration on particle size distribution, crystal habit and morphology, and resultant crystal purity

Koay, Gregory F.L.; Chuah, Teong-Guan; Zainal-Abidin, Sumaiya; Ahmad, Salmiah; Choong, Thomas Shean Yaw

doi:10.1016/j.indcrop.2011.03.030

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…16 Thus, by using higher concentration of hydrogen peroxide, a higher relative conversion to oxirane can be achieved. This statement is supported by a few studies that uses high concentration of hydrogen peroxide in the epoxidation process 17,18 where both used 60% hydrogen peroxide in their studies and the result shows that they can achieve a higher percentage of RCO% by using concentrated hydrogen peroxide.…”

Section: Process Parameter Range/type Unitmentioning

confidence: 77%

Catalytic epoxidation of palm oleic acid by heterogeneous catalysts: Optimization and kinetic model

Azmi,

Azlee,

Jalil

2023

Env Prog and Sustain Energy

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Epoxidized vegetable oils can produce a natural‐based polymer product as chemical reaction intermediates, plasticisers, and stabilizers in polyvinyl chloride. This study aims to identify the effects of using different concentrations of hydrogen peroxide and the effect of different molar ratios of hydrogen peroxide on relative conversion to oxirane. Epoxidized palm oil was produced in situ using performic acid as epoxidation agents and titanium dioxide as a catalyst. The results indicated that a higher concentration of hydrogen peroxide at 50% concentration and the ratio of 2:1 of hydrogen peroxide to palm oil used in the in situ epoxidation of had provided a higher relative conversion to oxirane (50%) in reaction time (70 min). Fourier transformation infrared spectroscopy revealed the presence of an oxirane group at 1200 cm−1. Numerical kinetic modeling was developed with applied genetic algorithm optimization to find the process model that fit experimental data. Then, the kinetic rate, k parameters obtained k11 = 0.031 mol L−1 min−1, k12 = 3.159 mol L−1 min−1, k2 = 2.620 mol L−1 min−1 for epoxidation palm oil, and k3 = 1.19 × 10−5 mol L−1 min−1 in degradation process.

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Section: Process Parameter Range/type Unitmentioning

confidence: 77%

Catalytic epoxidation of palm oleic acid by heterogeneous catalysts: Optimization and kinetic model

Azmi,

Azlee,

Jalil

2023

Env Prog and Sustain Energy

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“…Crystallization is widely used in the pharmaceutical industry as a basic and green separation and purification method. Different solvents lead to significant differences in properties such as polymorphism, purity, crystal habit, product yield, and particle size distribution of the products of the crystallization process. − Solubility, as a fundamental thermodynamic data of crystallization, provides a benchmark for solvent selection during crystallization . Currently, solubility measurement methods and correlation methods are well established.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Intermolecular Interactions on the Dissolution Property of Aripiprazole

Zheng,

Huang,

Gao

et al. 2024

Crystal Growth & Design

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The measurement and prediction of solubilities of active pharmaceutical ingredients are crucial in the development of polymorphism and the crystallization process. In this work, the solubilities of aripiprazole (APZ) in 11 pure solvents were measured and correlated over the temperature range 293.15−333.15 K. It was found that in all studied solvents, the solubility of APZ increased with the increasing temperature throughout the entire investigated temperature range. In addition, the mixing and dissolution thermodynamic properties of APZ in 11 pure solvents were also calculated. The calculation results indicated that both the mixing and the dissolution processes of APZ are spontaneous. Moreover, the intermolecular interactions in APZ solutions were investigated by molecular surface electrostatic potential analysis, independent gradient model based on Hirshfeld partition analysis, and molecular dynamics simulations. The results showed that the van der Waals interactions had a significantly greater effect on the dissolution process of APZ than did the hydrogen bond interactions. The solubility of APZ was controlled by a combination of the relative magnitude of the newly formed solute−solvent intermolecular interactions and the solvent−solvent intermolecular interactions that were disrupted due to the addition of solute. Finally, a physical quantity, dissolution-driven energy (E dis-driven ), was proposed to predict the APZ dissolution tendency in different pure solvents, which was able to characterize the solubility orders of APZ in different pure solvents almost perfectly.

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“…Palm-based 9,10-dihydroxystearic acid (DHSA) is highly sought as a functional material, especially in the personal care and cosmetic fields, due to its different behavior as compared with ordinary fatty acids. − For example, DHSA can act as a thickener or gelling agent for oily phases in cosmetics, and a DHSA soap has higher foaming ability and detergency than a stearic acid soap. Herein, we report pH-responsive liquid marbles stabilized by DHSA, which are stable on substrates (solid and water) under acid solutions but disintegrate in a few seconds in alkaline solutions (pH > 7.5).…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Liquid Marbles Based on Dihydroxystearic Acid

Zhang

Jiang

et al. 2022

Langmuir

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Herein, we report pH-responsive liquid marbles stabilized by 9,10-dihydroxystearic acid (DHSA). The particle morphology and the pH-responsive behavior of the liquid marbles were investigated. The rolling time during the preparation of liquid marbles has a great influence on the thickness of powder adsorption and the stability of the marbles. Compared with the liquid marbles stabilized by other fatty acids (e.g., stearic acid and docosoic acid), the liquid marbles prepared by DHSA have a much higher mechanical robustness. The increase in the number of hydroxyl groups on the carbon chain of fatty acids improves the mechanical robustness of the liquid marbles. Such liquid marbles immediately disintegrated on the surface of an alkaline solution or after exposure to NH 3 gas, which extends their applications in the NH 3 sensor and chemical reactions.

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Solvent crystallization of palm based dihydroxystearic acid with isopropyl alcohol: Effects of solvent quantity and concentration on particle size distribution, crystal habit and morphology, and resultant crystal purity

Cited by 7 publications

References 6 publications

Catalytic epoxidation of palm oleic acid by heterogeneous catalysts: Optimization and kinetic model

Catalytic epoxidation of palm oleic acid by heterogeneous catalysts: Optimization and kinetic model

The Effect of Intermolecular Interactions on the Dissolution Property of Aripiprazole

pH-Responsive Liquid Marbles Based on Dihydroxystearic Acid

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