Solvent and catalyst free synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones by twin screw extrusion

Abstract

Rapid, high yielding, and solvent and catalyst free synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones by twin screw extrusion.

Rate and Yield Enhancements in Nucleophilic Aromatic Substitution Reactions via Mechanochemistry

“…Now consider mechanochemically performed reactions. These solvent-free reactions use grinding/crushing/pulverizing/shearing forces to induce chemical reactivity. − On small scale they are performed in vibrational or planetary ball-mill reactors, and on large scale they have seen significant success in twin-screw extruders. − Of interest here is that in mechanochemical reactions there is no need for dissolving power and without solvent there are reduced practical limits on reaction temperature. Now that strict control of temperature in vibratory ball mill reactors has been demonstrated several times in literature, − the door is open to applying mechanochemistry to reactions like the S N Ar.…”

Transparent Cellulose‐Based Film with High UV‐Blocking Performance Fabricated by Surface Modification using Biginelli Reaction

“…In addition, the reaction temperature is relatively mild (100 °C), with the by‐product of the reaction being water. [ 35 ] Therefore, the Bignelli reaction used in this work is an efficient and eco‐friendly process.…”

The new life of traditional water treatment flocculant polyaluminum chloride (PAC): a green and efficient micro–nano reactor catalyst in alcohol solvents

“…15,16 For multicomponent reactions, the Biginelli reaction is the simplest way to construct dicyanopyridone/pyrimidinone (DHPMs) and its derivatives. [17][18][19] The reaction product has been widely used as an anti-tumor, anti-bacterial, anti-inammatory, and anti-viral agent, as well as in other medical elds. [20][21][22] Since the discovery of the reaction more than 100 years ago, researchers have successively developed different catalytic systems and synthesis strategies; [23][24][25][26][27][28] despite all the improvements toward better reaction conditions, many drawbacks associated with this transformation still exist.…”