Solvation behaviour of an antihelmintic drug in aqueous solutions of sodium chloride and glucose at different temperatures

Bhattacharya, Doyel M.; Dhondge, Sudhakar S.; Zodape, Sangesh P.

doi:10.1016/j.jct.2016.05.025

Cited by 38 publications

(16 citation statements)

References 57 publications

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“…Solutes were carefully placed in vacuum desiccators, maintaining the conditions as reported in our previous paper. 4 Specifications of these solutes are given in Table 1. The solutions were prepared using doubly-distilled Millipore water on a molality basis by the electronic balance (Shimadzu model AUW220D) without buoyancy corrections, having an uncertainty in weight up to ±0.1 mg.…”

Section: Methodsmentioning

confidence: 99%

“…The calibration of the instrument and the procedure was realized in the same manner as prescribed in the literature. 4 The reference fluids used for the calibration of the densimeter are ultrapure water and aqueous solutions of NaCl and D-glucose. The results well agreed with the literature values at the experimental temperatures.…”

Section: Methodsmentioning

confidence: 99%

“…The results well agreed with the literature values at the experimental temperatures. 1,4,10,11 The uncertainty in the density was found on the order of ±0.05 kg•m −3 , so the combined expanded uncertainty was calculated to be U ρ (ρ) = 0.1 kg•m −3 . For the acoustic measurement, the working frequency of the instrument is 3 MHz, and the uncertainty evaluated at different temperatures, i.e., T = (298.15 to 318.15) K, was found to be equal to 0.5 m•s −1 .…”

Section: Methodsmentioning

confidence: 99%

“…This reflects the strong drug−solvent interactions between the drug and both of the amino acids in the ternary solutions, respectively. 4 The non-negative values of V ϕ 0 could also be attributed to the reduction in the electrostriction or hydration from the second solvation layer of the ionic group as a result of the increase in temperature.…”

Section: Methodsmentioning

confidence: 99%

“…3 Thus, a detailed study of different thermodynamic properties of the drug of interest in the aqueous environment and in the presence of important metabolites such as amino acids, carbohydrates, and salts enables us to clarify the picture of the varied molecular interactions of the cosolutes with hydrophilic and hydrophobic moieties of the drug. 4 These interactions can also be extended to understand the conformational stability of proteins in the biological system. The influence of salt on the stability, structure, and properties of proteins has been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Volumetric and Acoustic Properties of Procainamide Hydrochloride in Aqueous Binary and (Water + Amino Acid) Ternary Mixtures at Different Temperatures

et al. 2017

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For effective drug design and development, an integrated process utilizing all available information from structural, thermodynamic, and biological studies plays a very important role. To understand the energy basis of molecular interactions utilizing various thermodynamic methods, volumetric and acoustic studies are vital early in the development process of any drug toward an optimal energy interaction profile while retaining a good pharmacological assay. In this article, we are reporting the data of densities (ρ) and speeds of sound (u) of an antiarrhythmic agent, namely, procainamide hydrochloride in an aqueous binary and aqueous solution of amino acids, i.e., l-alanine and l-valine at T = (298.15, 308.15 and 318.15) K. Different thermodynamic parameters such as the apparent molar volume (V ϕ) of the solute, the isentropic compressibility (κs) of the solution, and the apparent molar isentropic compressibility (κϕ) of procainamide hydrochloride in water and aqueous solutions of l-alanine and l-valine have been computed using the density and speed of sound data at different temperatures. The limiting apparent molar volume (V ϕ 0) of solute and the limiting apparent molar compressibility (κϕ 0) of solute in binary and ternary aqueous solutions have been obtained by extrapolating the plots. The results have been interpreted in light of the competing solute–solute and solute–solvent interactions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of Volumetric and Acoustic Properties of Procainamide Hydrochloride in Aqueous Binary and (Water + Amino Acid) Ternary Mixtures at Different Temperatures

et al. 2017

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Physicochemical studies of adenosine in the presence of aqueous caffeine and theophylline solutions, & sodium valproate with γ‐amino butyric acid in aqueous medium at T = (288.15–318.15) K and at p = 1 × 10⁵ Pa

Beri,

Kant,

Banipal

2024

Vietnam Journal of Chemistry

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In human body, drug‐neurotransmitter interactions have been the most significant process. Whereas, adverse reactions may be accompanied by unexpected interaction, which puts an individual in danger of life. Thus, the interactions between adenosine (ADN) and sodium valproate (SV) with caffeine (CAF), theophylline (TPY) and γ‐amino butyric acid (GABA) have been studied. Various properties like densities, ρ and speed of sound, u, have been used to calculate apparent molar volumes (V2,ϕ) and apparent molar isentropic compression (Ks,2,ϕ) for ADN and SV in aqueous (5, 10, 15 and 20 mmol kg−1) CAF, TPY and GABA solutions at T = (288.15–318.15) K and at pressure p = 1 × 105 Pa. The results of various interactions that occurred by mixing the solutions have been interpreted. Exothermicity is indicated by the negative values of standard molar enthalpy of transfer, ΔtrΔdilH0, obtained from the calorimetry. UV‐absorption and 1H NMR studies suggest that there is a dominance of solute‐cosolute interactions due to hyperchromic shift and shielding effect.

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Temperature dependent micellar study of streptomycin sulfate in aqueous amino acid solutions: physicochemical approach

Chauhan,

Singh,

Manish

et al. 2023

Colloid Polym Sci

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Solvation behaviour of an antihelmintic drug in aqueous solutions of sodium chloride and glucose at different temperatures

Cited by 38 publications

References 57 publications

Investigation of Volumetric and Acoustic Properties of Procainamide Hydrochloride in Aqueous Binary and (Water + Amino Acid) Ternary Mixtures at Different Temperatures

Investigation of Volumetric and Acoustic Properties of Procainamide Hydrochloride in Aqueous Binary and (Water + Amino Acid) Ternary Mixtures at Different Temperatures

Physicochemical studies of adenosine in the presence of aqueous caffeine and theophylline solutions, & sodium valproate with γ‐amino butyric acid in aqueous medium at T = (288.15–318.15) K and at p = 1 × 10⁵ Pa

Temperature dependent micellar study of streptomycin sulfate in aqueous amino acid solutions: physicochemical approach

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Solvation behaviour of an antihelmintic drug in aqueous solutions of sodium chloride and glucose at different temperatures

Cited by 38 publications

References 57 publications

Investigation of Volumetric and Acoustic Properties of Procainamide Hydrochloride in Aqueous Binary and (Water + Amino Acid) Ternary Mixtures at Different Temperatures

Investigation of Volumetric and Acoustic Properties of Procainamide Hydrochloride in Aqueous Binary and (Water + Amino Acid) Ternary Mixtures at Different Temperatures

Physicochemical studies of adenosine in the presence of aqueous caffeine and theophylline solutions, & sodium valproate with γ‐amino butyric acid in aqueous medium at T = (288.15–318.15) K and at p = 1 × 105 Pa

Temperature dependent micellar study of streptomycin sulfate in aqueous amino acid solutions: physicochemical approach

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Physicochemical studies of adenosine in the presence of aqueous caffeine and theophylline solutions, & sodium valproate with γ‐amino butyric acid in aqueous medium at T = (288.15–318.15) K and at p = 1 × 10⁵ Pa