Solution-phase synthesis of a β-amino alcohol combinatorial library

Bismuth(III)-Catalyzed Hydrolysis of Epoxides and Aziridines: an Efficient Synthesis of vic-diols and β-Amino Alcohols

“…They are well-known carbon electrophiles capable of reacting with various nucleophiles and their ability to undergo regioselective ring-opening reactions contributes largely to their synthetic value [6,7]. In particular, vicdiols and b-amino alcohols are important classes of compounds in the synthesis of biologically active natural products, unnatural amino acids and chiral auxiliaries [8][9][10][11][12]. Some of these b-amino alcohols are being used as starting materials for the preparation of oxazolines, which have been widely explored as protecting groups for carboxylic acids [13].…”

Aluminum tris (dodecyl sulfate) trihydrate Al(DS)3·3H2O as an efficient Lewis acid–surfactant-combined catalyst for organic reactions in water

“…␤-Amino alcohols are important intermediates for the synthesis of a vast range of biologically active natural and synthetic products, for the synthesis of amino acids, and also used as chiral auxiliaries/ligands for asymmetric synthesis [47][48][49][50][51][52][53][54][55][56]. One of the most accessible synthetic procedures for the preparation of ␤-amino alcohols involves the ring opening of epoxides with amines .…”

Microwave promoted synthesis of β-aminoalcohols in dry media†

“…4 As a consequence, several approaches towards their preparation have been reported in the literature. 5 Even though aminolysis of expoxides is an attractive route to aminoalcohols, this reaction is slow and affords aminoalcohols in low yields along with the recovered starting materials. 6 Attempts to effect the aminolysis of epoxides by subjecting them to microwave irradiation with ammonium acetate afforded good yields of b-aminoalcohols with high regioselectivity.…”