Solution-Phase Surface Modification in Intact Poly(dimethylsiloxane) Microfluidic Channels

Sui, Guodong; Wang, Jinyi; Lee, Chung-Cheng; Lu, Weixing; Lee, Stephanie P.; Leyton, Jeffrey V.; Wu, Anna M.; Tseng, Hsian‐Rong

doi:10.1021/ac060605z

Cited by 223 publications

(215 citation statements)

References 33 publications

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“…Chemical modification relies on three primary methodologies for attaching a patent layer of alterant to the device surface: covalent attachment, [16][17][18] polymer grafting, [19][20][21][22] or matrix infiltration/chemisorption. 23 In each case, the longevity of the surface treatment is highly variable and depends strongly upon the usage conditions (see Sec.…”

Section: Introductionmentioning

confidence: 99%

Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies

2015

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The applicability of droplet-based microfluidic systems to many research fields stems from the fact that droplets are generally considered individual and selfcontained reaction vessels. This study demonstrates that, more often than not, the integrity of droplets is not complete, and depends on a range of factors including surfactant type and concentration, the micro-channel surface, droplet storage conditions, and the flow rates used to form and process droplets. Herein, a model microfluidic device is used for droplet generation and storage to allow the comparative study of forty-four different oil/surfactant conditions. Assessment of droplet stability under these conditions suggests a diversity of different droplet failure modes. These failure modes have been classified into families depending on the underlying effect, with both numerical and qualitative models being used to describe the causative effect and to provide practical solutions for droplet failure amelioration in microfluidic systems. V C 2015 AIP Publishing LLC.

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Section: Introductionmentioning

confidence: 99%

Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies

2015

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“…[31] The influence of the modification has been also studied and is found in literature [10,11,12,32,33]. Modified surface characteristics of our device were analyzed by contact angle measurement.…”

Section: Effect Of Surface Modification On Hydrophilicitymentioning

confidence: 99%

PDMS microfluidics developed for polymer based photonic biosensors

et al. 2014

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Abstract:In this work, advances in the fabrication technology and functional analysis of a polymer microfluidic system -as a significant part of a developed polymer photonic biosensor -are reported. Robust and cost-effective microfluidics in PDMS including sample preparation functions is designed and realized by using SU-8 moulding replica. Surface modification strategies using Triton X-100 and PDMS-PEO and their effect on device sealing and non-specific protein adsorption are investigated by contact angle measurement and in situ fluorescence microscopy.Response to Reviewers: Dear Editors and Reviewers, First of all, thank You for the effort in improving our paper. Regarding the reviewer comments, we made the following modifications regarding the latest version of the manuscript submitted. The modifications and the required supplements are submitted in pdf format with the revised manuscript.Thank You again for the efforts to improve our manuscript. Regards, Péter Fürjes

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“…The result is a self-assembled monolayer ͑SAM͒ at the interface, with an alkyl chain ͑with the desired functional group͒ exposed at the microchannel walls. 23,42,43 Depending on their functionality, SAMs and other thin organic layers provide resistance to biofouling, [44][45][46] a wettability contrast, 26,32 or intermediates for surface patterning. 25,26 The silanol groups present at glass and oxidized PDMS surfaces lead to a native negative surface potential in aqueous phases, except at very low pH ͑the point of zero charge for silica is pH ϳ 2-4͒.…”

Section: Microchannel Substratesmentioning

confidence: 99%

Surface patterning of bonded microfluidic channels

Priest

2010

Biomicrofluidics

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Microfluidic channels in which multiple chemical and biological processes can be integrated into a single chip have provided a suitable platform for high throughput screening, chemical synthesis, detection, and alike. These microchips generally exhibit a homogeneous surface chemistry, which limits their functionality. Localized surface modification of microchannels can be challenging due to the nonplanar geometries involved. However, chip bonding remains the main hurdle, with many methods involving thermal or plasma treatment that, in most cases, neutralizes the desired chemical functionality. Postbonding modification of microchannels is subject to many limitations, some of which have been recently overcome. Novel techniques include solution-based modification using laminar or capillary flow, while conventional techniques such as photolithography remain popular. Nonetheless, new methods, including localized microplasma treatment, are emerging as effective postbonding alternatives. This Review focuses on postbonding methods for surface patterning of microchannels.

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Solution-Phase Surface Modification in Intact Poly(dimethylsiloxane) Microfluidic Channels

Cited by 223 publications

References 33 publications

Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies

Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies

PDMS microfluidics developed for polymer based photonic biosensors

Surface patterning of bonded microfluidic channels

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